Abstract: Embodiments for intelligent discovery of preferred chemical reaction pathways to a synthesized target compound by a processor. Target compound data of a target compound a user intends to synthesize may be received. A preference score for one or more chemical reaction pathways to the target compound may be calculated based on one or more chemical reactions. One or more preferred chemical reaction pathways to the targeted compound may be determined using a modified retrosynthetic analysis according to the preference score for one or more chemical reactions.

Abstract: A back panel for a lighting device includes a front panel holding portion, the front panel holding portion has a configuration capable of setting a size of a gap between a front panel held by the front panel holding portion and a panel main body to an arbitrary size.

Abstract: To provide a highly reliable lighting-emitting device that hardly causes defects in case a wiring board is bent, while realizing high brightness by increasing a mounting density of surface-mounted LEDs on a wiring board that is rounded into a truncated cone shape or a cylinder shape, the light-emitting device comprises: the wiring board, a plurality of sets of pads arranged in a line along a circumferential direction of the wiring board, and a plurality of surface-mounted LEDs respectively fixed to the pads. The device satisfies y??1.04x+1.80, where (L) is a length of the circumference of the wiring board with the pads, (y) (y=s/L) is a ratio of a total sum (s) of the lengths in the circumferential direction of the pads relative to the circumferential length (L), and (x) is a curvature of the wiring board where the pads are arranged.

Abstract: A back panel for a lighting device includes a front panel holding portion, the front panel holding portion has a configuration capable of setting a size of a gap between a front panel held by the front panel holding portion and a panel main body to an arbitrary size.

Abstract: To provide a highly reliable lighting-emitting device that hardly causes defects in case a wiring board is bent, while realizing high brightness by increasing a mounting density of surface-mounted LEDs on a wiring board that is rounded into a truncated cone shape or a cylinder shape, the light-emitting device comprises: the wiring board, a plurality of sets of pads arranged in a line along a circumferential direction of the wiring board, and a plurality of surface-mounted LEDs respectively fixed to the pads. The device satisfies y??1.04x+1.80, where (L) is a length of the circumference of the wiring board with the pads, (y) (y=s/L) is a ratio of a total sum (s) of the lengths in the circumferential direction of the pads relative to the circumferential length (L), and (x) is a curvature of the wiring board where the pads are arranged.

Abstract: Embodiments for intelligent discovery of preferred chemical reaction pathways to a synthesized target compound by a processor. Target compound data of a target compound a user intends to synthesize may be received. A preference score for one or more chemical reaction pathways to the target compound may be calculated based on one or more chemical reactions. One or more preferred chemical reaction pathways to the targeted compound may be determined using a modified retrosynthetic analysis according to the preference score for one or more chemical reactions.

Abstract: Embodiments are directed to computer implemented method of assessing a relevancy of a pathway to a disease of interest, the pathway having a source and a target. The method includes developing an impact of the source on the pathway. The method further includes developing a value of targeting, based at least in part on an alteration of the pathway, the pathway with a drug of interest. The method further includes identifying a relationship between the source and the target within the pathway. The method further includes combining: the impact of the source on the pathway; the value of targeting, based at least in part on the alteration of the pathway, the pathway with a drug of interest; and the relationship between the source and the target within the pathway, wherein the combining results in an assessment that represents the relevancy of the pathway to the disease of interest.

Abstract: Embodiments are directed to computer implemented method of assessing a relevancy of a pathway to a disease of interest, the pathway having a source and a target. The method includes developing an impact of the source on the pathway. The method further includes developing a value of targeting, based at least in part on an alteration of the pathway, the pathway with a drug of interest. The method further includes identifying a relationship between the source and the target within the pathway. The method further includes combining: the impact of the source on the pathway; the value of targeting, based at least in part on the alteration of the pathway, the pathway with a drug of interest; and the relationship between the source and the target within the pathway, wherein the combining results in an assessment that represents the relevancy of the pathway to the disease of interest.

Abstract: Embodiments are directed to a computer implemented method of assessing a relevancy of a drug to a disease state of a patient. The method includes assessing an impact of the drug on driver genes (DGs) of the disease state of the patient, assessing an impact of the drug on druggable target genes (DTs) of the drug, and assessing the relationship between the DGs and DTs that are in one of a plurality of biological pathways of the disease state of the patient. The method further includes combining the impact of the drug on the DGs, the impact of the drug on the DTs, and the relationship between the DGs and DTs that are in the one of the biological pathways, wherein the combining results in an assessment of the relevancy of the drug to the disease state of the patient.

Abstract: Embodiments are directed to computer implemented method of assessing a relevancy of a pathway to a disease of interest, the pathway having a source and a target. The method includes developing an impact of the source on the pathway. The method further includes developing a value of targeting, based at least in part on an alteration of the pathway, the pathway with a drug of interest. The method further includes identifying a relationship between the source and the target within the pathway. The method further includes combining: the impact of the source on the pathway; the value of targeting, based at least in part on the alteration of the pathway, the pathway with a drug of interest; and the relationship between the source and the target within the pathway, wherein the combining results in an assessment that represents the relevancy of the pathway to the disease of interest.

Abstract: Embodiments are directed to computer implemented method of assessing a relevancy of a pathway to a disease of interest, the pathway having a source and a target. The method includes developing an impact of the source on the pathway. The method further includes developing a value of targeting, based at least in part on an alteration of the pathway, the pathway with a drug of interest. The method further includes identifying a relationship between the source and the target within the pathway. The method further includes combining: the impact of the source on the pathway; the value of targeting, based at least in part on the alteration of the pathway, the pathway with a drug of interest; and the relationship between the source and the target within the pathway, wherein the combining results in an assessment that represents the relevancy of the pathway to the disease of interest.