Patents by Inventor Takahiko Mandai
Takahiko Mandai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6005100Abstract: Disclosed are a novel desiccant containing a non-reducing anhydrous trehalose as an effective ingredient; a dehydration of hydrous matters, e.g. food products, pharmaceuticals and cosmetics, therewith; and dehydrated products obtained by the dehydration. Such hydrous matters are dehydrated without causing alteration or deterioration by incorporating anhydrous trehalose into the hydrous matters to convert the anhydrous trehalose into hydrous crystalline trehalose. The anhydrous trehalose are anhydrous crystalline trehalose and hydrous amorphous trehalose.Type: GrantFiled: June 13, 1997Date of Patent: December 21, 1999Assignee: Kabushiki Kaisha Hayashibara Seitbutsu Kagaku KenkyujoInventors: Takahiko Mandai, Takashi Shibuya, Toshiyuki Sugimoto, Toshio Miyake
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Patent number: 5922691Abstract: Novel crystalline maltotetraosyl glucoside is obtained by crystallizing maltotetraosyl glucoside from a solution of maltotetraosyl glucoside, prepared by either exposing an aqueous solution of maltopentaose to the action of a non-reducing saccharide-forming enzyme or an aqueous solution which contains trehalose or a non-reducing saccharide to the action of cyclomaltodextrin glucanotransferase. The crystalline maltotetraosyl glucoside has non-hygroscopicity, non-reducibility, superior solubility, less fermentability, and other satisfactory properties of stabilizing oligopeptides and biologically-substances as well as preventing retrogradation of amylaceous substances. These features render the crystalline maltotetraosyl glucoside very useful in various compositions including foods, beverages, cosmetics, pharmaceuticals and shaped bodies.Type: GrantFiled: April 7, 1997Date of Patent: July 13, 1999Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Takahiko Mandai, Takashi Shibuya, Toshiyuki Sugimoto, Toshio Miyake
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Patent number: 5919668Abstract: In the production of non-reducing saccharides such as trehalose, alpha-glycosyl trehaloses and alpha-glycosyl alpha-glycosides where a solution of liquefied starch is subjected either to non-reducing saccharide-forming enzyme or non-reducing saccharide-forming enzyme and trehalose-releasing enzyme, combinations with starch-debranching enzyme and/or cyclomaltodextrin glucanotransferase improve the yields for such non-reducing saccharides to levels which are hardly attainable only with reducing-saccharide-forming enzyme and trehalose-releasing enzyme. The non-reducing saccharides and less reducing reducing saccharides containing the same commonly bear a variety of desirable properties which make them useful in a variety of compositions including food products, cosmetics and medicines.Type: GrantFiled: June 27, 1995Date of Patent: July 6, 1999Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Takahiko Mandai, Takashi Shibuya, Toshiyuki Sugimoto, Toshio Miyake
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Patent number: 5906924Abstract: High quality trehalose derivatives are readily prepared in a considerably high yield by reacting anhydrous trehalose with reactive reagents under anhydrous conditions. The trehalose derivatives can be used in a variety of fields in the production, the chemical synthesis, and the enzymatic synthesis of foods, cosmetics, pharmaceuticals, detergents and chemicals as surfactants, humectants, skin-beautifying agents, antitumor agents, and intermediates for chemical and enzymatic syntheses.Type: GrantFiled: November 28, 1995Date of Patent: May 25, 1999Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kaguku KenkyujoInventors: Takahiko Mandai, Takashi Shibuya, Toshiyuki Sugimoto
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Patent number: 5780620Abstract: Novel non-reducing oligosaccharide having a structure represented by the formula of alpha-D-oligoglucosyl alpha-D-oligoglucoside is obtained by exposing either an aqueous solution which contains trehalose and an alpha-glucosyl saccharide or an aqueous solution which contains a non-reducing saccharide bearing a trehalose structure at its end to a saccharide-transferring enzyme. The oligosaccharide has a reduced sweetness, superior stability, appropriate viscosity and less or no susceptibility to crystallization or superior solubility when in crystalline form. These features make the oligosaccharide very useful in various compositions including foods, beverages, cosmetics, pharmaceuticals and shaped bodies.Type: GrantFiled: December 10, 1996Date of Patent: July 14, 1998Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Takahiko Mandai, Takashi Shibuya, Toshiyuki Sugimoto, Toshio Miyake
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Patent number: 5693788Abstract: Disclosed are a novel desiccant containing a non-reducing anhydrous trehalose as an effective ingredient; a dehydration of hydrous matters, e.g. food products, pharmaceuticals and cosmetics, therewith; and dehydrated products obtained by the dehydration. Such hydrous matters are dehydrated without causing alteration or deterioration by incorporating anhydrous trehalose into the hydrous matters to convert the anhydrous trehalose into hydrous crystalline trehalose. The anhydrous trehalose are anhydrous crystalline trehalose and hydrous amorphous trehalose.Type: GrantFiled: January 25, 1996Date of Patent: December 2, 1997Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Takahiko Mandai, Takashi Shibuya, Toshiyuki Sugimoto, Toshio Miyake
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Patent number: 5543513Abstract: Disclosed are a novel desiccant containing a non-reducing anhydrous trehalose as an effective ingredient; a dehydration of hydrous matters, e.g. food products, pharmaceuticals and cosmetics, therewith; and dehydrated products obtained by the dehydration. Such hydrous matters are dehydrated without causing alteration or deterioration by incorporating anhydrous trehalose into the hydrous matters to convert the anhydrous trehalose into hydrous crystalline trehalose. The anhydrous trehalose are anhydrous crystalline trehalose and hydrous amorphous trehalose.Type: GrantFiled: February 23, 1995Date of Patent: August 6, 1996Assignees: Kabushiki Kaisha Hayashibara, Seibutsu Kagaku KenkyujoInventors: Takahiko Mandai, Takashi Shibuya, Toshiyuki Sugimoto, Toshio Miyake
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Patent number: 5468850Abstract: Disclosed is an industrial-scale preparation of a high 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid content product with an improved purity, the preparation comprising subjecting a solution containing 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid and a saccharide derivative of L-ascorbic acid exhibiting a direct reducing activity to an oxidation treatment, subjecting the resultant mixture ti column chromatography using a strongly-acidic cation exchange resin, and recoverying the resultant high 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid content fraction. Thus, the preparatiobn has a great significance in the industrial field.Type: GrantFiled: October 21, 1992Date of Patent: November 21, 1995Assignees: Kabushiki Kaisha Hayashibara, Seibutsu Kagaku KenkyujoInventors: Takahiko Mandai, Masaru Yoneyama, Shuzo Sakai
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Patent number: 5272136Abstract: 5-O-.alpha.-D-Glucopyranosyl-L-ascorbic acid is a novel derivative of L-ascorbic acid which has a direct reducing activity and a satisfiable stability, as well as being readily hydrolyzed in vivo to form L-ascorbic acid. The 5-O-.alpha.-D-glucopyranosyl-L-ascorbic acid is prepared by allowing a saccharide-transferring enzyme together with or without .alpha.-glucosidase to a solution containing an a-glucosyl saccharide and L-ascorbic acid, and suitably used in food products, agents of anti-susceptive diseases and cosmetics containing thereof.Type: GrantFiled: April 30, 1993Date of Patent: December 21, 1993Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Takahiko Mandai, Masaru Yoneyama, Shuzo Sakai
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Patent number: 5252722Abstract: 5-O-.alpha.-D-Glucopyranosyl-L-ascorbic acid is a novel derivative of L-ascorbic acid which has a direct reducing activity and a satisfiable stability, as well as being readily hydrolyzed in vivo to form L-ascorbic acid. The 5-O-.alpha.-D-glucopyranosyl-L-ascorbic acid is prepared by allowing a saccharide-transferring enzyme together with or without .alpha.-glucosidase to a solution containing an .alpha.-glucosyl saccharide and L-ascorbic acid, and suitably used in food products, agents of anti-susceptive diseases and cosmetics containing thereof.Type: GrantFiled: October 21, 1992Date of Patent: October 12, 1993Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Takahiko Mandai, Masaru Yoneyama, Shuzo Sakai