Patents by Inventor Takahiko Matsushita
Takahiko Matsushita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230393129Abstract: Provided with a sheet and a backing sheet for reducing a background luminescence occurs in a fluorescent immunochromatography method. In an immunochromatographic kit having at least a membrane and a backing sheet, wherein a luminescence suppression sheet is provided between the membrane and the backing sheet, and a quantum yield measured by an absolute PL quantum yield spectrometer C11347 manufactured by Hamamatsu Photonics K.K. is 0.40% or less when the luminescence suppression sheet is irradiated with an excitation light having a wavelength of 365 nm.Type: ApplicationFiled: November 25, 2021Publication date: December 7, 2023Inventors: Ken HATANO, Koji MATSUOKA, Takahiko MATSUSHITA
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Patent number: 11396567Abstract: It is an object of the present invention to provide a fine fluorescent particle, which does not cause concentration quenching and has low ecotoxicity. Specifically, the present invention relates to a fine fluorescent particle containing an AIE-active compound, the particle consisting of a network polymer, wherein the fine fluorescent particle is characterized in that the AIE-active compound is, for example, a compound represented by the following formula (1): wherein E represents silicon or germanium; R1 and R2, which are the same or different, each represent a hydrocarbon group containing 1 to 6 carbon atoms, or a substituted or unsubstituted phenyl group; and R3, R4, R5 and R6, which are the same or different, each represent a substituted or unsubstituted phenyl group.Type: GrantFiled: September 26, 2017Date of Patent: July 26, 2022Assignee: NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITYInventors: Ken Hatano, Takahiko Matsushita, Daisuke Fujikawa, Koji Matsuoka
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Publication number: 20190276735Abstract: It is an object of the present invention to provide a fine fluorescent particle, which does not cause concentration quenching and has low ecotoxicity. Specifically, the present invention relates to a fine fluorescent particle containing an AIE-active compound, the particle consisting of a network polymer, wherein the fine fluorescent particle is characterized in that the AIE-active compound is, for example, a compound represented by the following formula (1): wherein E represents silicon or germanium; R1 and R2, which are the same or different, each represent a hydrocarbon group containing 1 to 6 carbon atoms, or a substituted or unsubstituted phenyl group; and R3, R4, R5 and R6, which are the same or different, each represent a substituted or unsubstituted phenyl group.Type: ApplicationFiled: September 26, 2017Publication date: September 12, 2019Applicant: National University Corporation SAITAMA UNIVERSITYInventors: Ken Hatano, Takahiko Matsushita, Daisuke Fujikawa, Koji Matsuoka
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Patent number: 9346867Abstract: Cancer-associated O-glycopeptide combination epitopes derived from the VNTR of MUC1 are disclosed. Autoantibodies present in human sera target the combination epitopes and are reduced or absent in cancer patients. The epitopes are useful as therapeutic and immunoprophylactic cancer vaccines. Monoclonal antibodies directed against the epitopes are also useful as immunotherapeutics for treatment and prevention of cancer. Diagnostic methods using the epitopes and antibodies are also disclosed.Type: GrantFiled: April 15, 2011Date of Patent: May 24, 2016Assignee: Sumitomo Bakelite Co., Ltd.Inventors: Shin-Ichiro Nishimura, Takahiko Matsushita, Yoshiaki Miura
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Patent number: 9310358Abstract: A sugar chain array containing a sugar chain immobilized thereon for detecting binding between an analyte and a sugar chain, and a sugar chain array having the sugar chain immobilized thereon that is capable of inhibiting non-specific adsorption and binding of an analyte without having to coat the array with an adsorption inhibitor. A specific sugar chain is immobilized on the array, and is useful for detecting binding between the sugar chain and an analyte, such as a pathogen of an infectious disease or an excretion thereof. In addition, in the array, when a base material is coated with a polymeric compound having a unit having a primary amino group, a unit for maintaining hydrophilicity, and a unit having a hydrophobic group, the sugar chain is immobilized efficiently and non-specific adsorption and binding of the analyte can be effectively inhibited.Type: GrantFiled: July 29, 2011Date of Patent: April 12, 2016Assignees: SUMITOMO BAKELITE CO., LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Shin-Ichiro Nishimura, Takahiko Matsushita, Hideyuki Shimaoka, Wataru Takada, Kohta Igarashi, Midori Abe, Hiroki Abe, Masao Fukushima
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Patent number: 9267942Abstract: A sugar chain array containing a sugar chain immobilized thereon for detecting binding between an analyte and a sugar chain, and a sugar chain array having the sugar chain immobilized thereon that is capable of inhibiting non-specific adsorption and binding of an analyte without having to coat the array with an adsorption inhibitor. A specific sugar chain is immobilized on the array, and is useful for detecting binding between the sugar chain and an analyte, such as a pathogen of an infectious disease or an excretion thereof. In addition, in the array, when a base material is coated with a polymeric compound having a unit having a primary amino group, a unit for maintaining hydrophilicity, and a unit having a hydrophobic group, the sugar chain is immobilized efficiently and non-specific adsorption and binding of the analyte can be effectively inhibited.Type: GrantFiled: July 29, 2011Date of Patent: February 23, 2016Assignees: SUMITOMO BAKELITE CO., LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Shin-Ichiro Nishimura, Takahiko Matsushita, Hideyuki Shimaoka, Wataru Takada, Kohta Igarashi, Midori Abe, Hiroki Abe, Masao Fukushima
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Publication number: 20130316932Abstract: The present invention provides: a glycopeptide array which is useful for the detection of the binding between a substance to be detected and a glycopeptide; and an array which can inhibit the non-specific adsorption or binding of a substance to be detected without the need of coating any adsorption-inhibiting agent and which has the glycopeptide immobilized thereon. In the present invention, it was found that a glycopeptide that has a molecule having a carbonyl group bound to a peptide moiety thereof can be immobilized on a substrate that is coated with a polymer compound containing a unit having a primary amino group with high efficiency through the carbonyl group.Type: ApplicationFiled: November 22, 2011Publication date: November 28, 2013Applicants: SUMITOMO BAKELITE CO., LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Shin-Ichiro Nishimura, Takahiko Matsushita, Hideyuki Shimaoka, Wataru Takada, Kohta Igarashi, Midori Abe, Hiroki Abe, Masao Fukushima
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Publication number: 20130196881Abstract: A sugar chain array containing a sugar chain immobilized thereon for detecting binding between an analyte and a sugar chain, and a sugar chain array having the sugar chain immobilized thereon that is capable of inhibiting non-specific adsorption and binding of an analyte without having to coat the array with an adsorption inhibitor. A specific sugar chain is immobilized on the array, and is useful for detecting binding between the sugar chain and an analyte, such as a pathogen of an infectious disease or an excretion thereof. In addition, in the array, when a base material is coated with a polymeric compound having a unit having a primary amino group, a unit for maintaining hydrophilicity, and a unit having a hydrophobic group, the sugar chain is immobilized efficiently and non-specific adsorption and binding of the analyte can be effectively inhibited.Type: ApplicationFiled: July 29, 2011Publication date: August 1, 2013Applicants: National University Corporation Hokkaido University, Sumitomo Bakelite Co., Ltd.Inventors: Shin-Ichiro Nishimura, Takahiko Matsushita, Hideyuki Shimaoka, Wataru Takada, Kohta Igarashi, Midori Abe, Hiroki Abe, Masao Fukushima
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Publication number: 20130034557Abstract: Cancer-associated O-glycopeptide combination epitopes derived from the VNTR of MUC1 are disclosed. Autoantibodies present in human sera target the combination epitopes and are reduced or absent in cancer patients. The epitopes are useful as therapeutic and immunoprophylactic cancer vaccines. Monoclonal antibodies directed against the epitopes are also useful as immunotherapeutics for treatment and prevention of cancer. Diagnostic methods using the epitopes and antibodies are also disclosed.Type: ApplicationFiled: April 15, 2011Publication date: February 7, 2013Applicant: EZOSE SCIENCES, INC.Inventors: Shin-Ichiro Nishimura, Takahiko Matsushita, Yoshiaki Miura
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Patent number: 7518233Abstract: A sealing structure for multi-chip modules stable in cooling performance and excelling in sealing reliability is to be provided. The under face of a frame 5 compatible with a wiring board 1 in thermal expansion rate is fixed with solder 8 to the face of the wiring board 1 for mounting semiconductor devices 2; a rubber O-ring 15 is placed between the upper face of the frame 5 and the under face of the circumference of an air-cooled: heat sink 7; the plastic member 6 making possible relative sliding is placed between the upper face of the circumference of the heat sink 7 and the upper frame 10; the upper face of a plastic member 6 is restrained with the inside middle stage of an upper frame 10; and the lower part of the upper frame 10 and the frame 5 are fastened together with bolts 9.Type: GrantFiled: June 9, 2000Date of Patent: April 14, 2009Assignees: Hitachi, Ltd., Hitachi Information Technology Co., Ltd.Inventors: Kouichi Takahashi, Kenichi Kasai, Takahiro Daikoku, Takayuki Uda, Toshitada Netsu, Takeshi Yamaguchi, Takahiko Matsushita, Osamu Maruyama