Abstract: A PPR protein with high performance is provided. A PPR protein that binds to a long nucleotide sequence is provided by linking motifs in a number larger than conventionally used 7 to 14. A PPR motif is provided, of which typical examples are the followings: (A-1) a PPR motif consisting of the sequence of SEQ ID NO: 9 or 401, (C-1) a PPR motif consisting of the sequence of SEQ ID NO: 10, (G-1) a PPR motif consisting of the sequence of SEQ ID NO: 11, and (U-1) a PPR motif consisting of the sequence of SEQ ID NO: 12. These motifs are useful as PPR motifs for adenine, cytosine, guanine, and uracil in a target nucleotide sequence, respectively.

Abstract: A health data processing system in which an arithmetic unit can gain access to a database storing basic data of residents, health data of residents, and social capital index measurement data is provided. The health data processing system includes: an individual health condition analysis part which analyzes an individual health condition being each resident's health condition with use of the health data; a regional health condition analysis part which analyzes a regional health condition being a health condition of residents who belong to a region with use of the health data; an SCI derivation part which derives a regional SCI being a social capital index for every region with use of the social capital index measurement data; and an individually providing information generation part which generates information contributing to residents' health with use of the individual health condition, the regional health condition, and the regional SCI.

Abstract: A radar distance measuring device having a BPF type ??ADC and capable of controlling a band of a BBF and modulation setting of a chirp signal in conjunction therewith is provided. A chirp signal generated by a synthesizer is distributed to a transmission antenna and each of mixers at a reception side. The chirp signal is amplified and irradiated from the transmission antenna to an object as radar. The radar reflected by the objects received by reception antennas, and is then mixed with the chirp signal from the synthesizer by the mixers to generate IF signals. These IF signals are respectively outputted to ADCs via anti-aliasing filters. Each of the ADCs is as oversampling ??ADC. The IF signals are sampled by the ??ADC, and are converted into a digital signal.

Abstract: In order to improve aggregation property of a PPR protein, the A6 amino acid of the 1st PPR motif from the N-terminus (M1) is made more hydrophilic. Further, the A9 amino acid of M1 is made to be a hydrophilic amino acid or glycine. The A6 amino acid is preferably asparagine or aspartic acid, and the A9 amino acid is preferably glutamine, glutamic acid, lysine, or glycine. Proteins containing such a PPR motif as M1 motif may have not only improved aggregation property, but also high binding power to a target nucleic acid.

Abstract: A ceramic-copper composite having a flat plate shape, including: a ceramic layer; a copper layer; and a brazing material layer present between the ceramic layer and the copper layer, in which a specified Expression (1) is satisfied in a cut surface of the copper layer obtained when the ceramic-copper composite is cut at a plane perpendicular to a main surface of the ceramic-copper composite, where S(102)% is an area ratio occupied by copper crystals having a crystal orientation of which an inclination from a crystal orientation of (102) plane is within 10°, S(101)% is an area ratio occupied by copper crystals having a crystal orientation of which an inclination from a crystal orientation of (101) plane is within 10°, S(111)% is an area ratio occupied by copper crystals having a crystal orientation of which an inclination from a crystal orientation of (111) plane is within 10°, and S(112)% is an area ratio occupied by copper crystals having a crystal orientation of which an inclination from a crystal orientati

Abstract: A temperature abnormality detection device includes a plurality of infrared temperature sensors respectively capable of detecting temperature in a different detection area of an equipment, and a device body including a temperature abnormality determination unit that determines that the temperature in the detection area detected by each of the plurality of infrared temperature sensors is abnormal when the temperature in the detection area is higher than a reference temperature. The plurality of infrared temperature sensors is connected to each other by crossover wiring.

Abstract: Workpieces are disposed between a pair of side walls in a heat treatment chamber. A centrifugal fan is disposed to face the workpieces inside the heat treatment chamber, and sucks gas from the workpiece side and generates air current. In regions at the respective side wall sides relative to an intermediate position between the pair of side walls, an air current regulation unit regulates the air current so as to restrict flows of the air current from the centrifugal fan to the respective side wall sides when a rotary blade of the centrifugal fan rotates in regions in which outer circumferential edge portions of the rotating rotary blade separate from the respective side walls, and allows the flows in regions in which the outer circumferential edge portions of the rotating rotary blade approach the respective side walls.

Abstract: A registration apparatus is configured to access a network formed of a set of first nodes and first edges, the first nodes each representing a first feature vector including a plurality of elements, the first edges each coupling two first nodes representing two first feature vectors to each other based on two first feature vectors, a processor in the registration apparatus is configured to execute: obtaining processing of obtaining a second feature vector; and registration processing of registering a second node representing the second feature vector to the network based on a similarity relationship among third feature vectors in a set of third feature vectors included in the set of first feature vectors, and coupling the second node and a third node representing the third feature vector to each other with a second edge, the number of third feature vectors being smaller than the number of first feature vectors.

Abstract: A ceramic circuit substrate having a metal plate bonded, by a bonding braze material, to at least one main surface of a ceramic substrate, wherein the bonding braze material contains, as metal components, 0.5 to 4.0 parts by mass of at least one active metal selected from among titanium, zirconium, hafnium, and niobium, with respect to 100 parts by mass, in total, of 93.0 to 99.4 parts by mass of Ag, 0.1 to 5.0 parts by mass of Cu, and 0.5 to 2.0 parts by mass of Sn; and Cu-rich phases in a bonding braze material layer structure between the ceramic substrate and the metal plate have an average size of 3.5 ?m or less and a number density of 0.015/?m2 or higher. A method for producing a ceramic circuit substrate includes bonding at a temperature of 855 to 900° C. for a retention time of 10 to 60 minutes.

Abstract: A method for designing a protein capable of binding in a DNA base selective manner or DNA base sequence specific manner is provided. According to the present invention, it was revealed that, with a protein that can bind in a DNA base-selective manner or a DNA base sequence-specific manner, which contains one or more, preferably 2 to 30, more preferably 5 to 25, most preferably 9 to 15, of PPR motifs having a structure of the following formula 1 (wherein, in the formula 1, Helix A is a part that can form an ?-helix structure; X does not exist, or is a part consisting of 1 to 9 amino acids; Helix B is a part that can form an ?-helix structure; and L is a part consisting of 2 to 7 amino acids), and having a specific combination of amino acids corresponding to a DNA base or DNA base sequence as amino acids of three positions of No. 1 A.A., No. 4 A.A., in Helix A of the formula 1 and No. “ii” (-2) A.A. contained in L of the formula 1, the aforementioned object could be achieved.

Abstract: A method of modifying the genome of an organism, wherein the modification method includes modifying the genome of the organism by using in a cell of the organism a protein having an optimal temperature for double-stranded DNA breakage activity in an ordinary temperature region.

Abstract: A ceramic-copper composite having a flat plate shape, including: a ceramic layer; a copper layer; and a brazing material layer present between the ceramic layer and the copper layer. When a region having a length of 1,700 ?m in a long-side direction is a region P on a cut surface of the ceramic-copper composite obtained when the ceramic-copper composite is cut with a plane perpendicular to a main surface of the ceramic-copper composite, an average crystal grain size D1 of copper crystals at least partially present in a region P1 within 50 ?m on a side of the copper layer from an interface between the ceramic layer and the brazing material layer in the region P is 30 ?m or more and 100 ?m or less.

Abstract: A stabilizer is provided with a restriction ring connected to a torsion portion at a connection portion adjacent to a bush. The restriction ring has a body, a female portion, a male portion, and a welded portion. The female portion has gripping portions with a spacing therebetween decreasing in the direction away from a valley bottom portion. The male portion has a neck portion, an expansion portion, and a contraction portion. The welded portion covers at least the range of the contraction portion and the valley bottom portion and melts in the plate thickness direction from the outer peripheral surface.

Abstract: The object of the present invention is to, by analyzing PPR proteins that act to bind to DNA with a prediction that RNA recognition rules of PPR motifs can also be used for recognition of DNA, find a PPR protein showing such a characteristic. According to the present invention, it was revealed that, with a protein that can bind in a DNA base-selective manner or a DNA base sequence-specific manner, which contains one or more, preferably 2 to 30, more preferably 5 to 25, most preferably 9 to 15, of PPR motifs having a structure of the following formula 1 (wherein, in the formula 1, Helix A is a part that can form an ?-helix structure; X does not exist, or is a part consisting of 1 to 9 amino acids; Helix B is a part that can form an ?-helix structure; and L is a part consisting of 2 to 7 amino acids), and having a specific combination of amino acids corresponding to a DNA base or DNA base sequence as amino acids of three positions of No. 1 A.A., No. 4 A.A., in Helix A of the formula 1 and No. “ii” (-2) A.A.

Abstract: [Problem to be Solved] The object of the present invention is to develop a method of regulating a target RNA. [Solution] There is provided a fusion protein comprising a functional domain which improves the protein expression level from mRNA and a PPR protein which can bind to a target mRNA in an RNA base-selective or RNA base sequence-specific manner.

Abstract: A method for designing a protein capable of binding in an RNA base selective manner or RNA base sequence specific manner is provided.

Abstract: A dispersant attached polytetrafluoroethylene particle on whose surface a dispersant having a fluorine atom is attached has a content of perfluorooctanoic acid of from 0 ppb to 25 ppb with respect to the polytetrafluoroethylene particle, and a composition contains a polytetrafluoroethylene particle and a dispersant having a fluorine atom in which a content of perfluorooctanoic acid is from 0 ppb to 25 ppb with respect to the polytetrafluoroethylene particle.

Abstract: The temperature threshold determining device includes a temperature data storage unit, a representative temperature value determining unit, and a temperature threshold determining unit. The temperature data storage unit stores temperature data that indicates the temperature of a target apparatus during past operation. The representative temperature value determining unit determines a representative temperature value of the target apparatus during the past operation, which is derived using the temperature data stored in the temperature data storage unit. The temperature threshold determining unit determines at least one temperature threshold by using the representative temperature value during the past operation and a reference temperature value that is preset and configured to prevent the temperature abnormality.

Abstract: A ceramic circuit substrate having a metal plate bonded, by a bonding braze material, to at least one main surface of a ceramic substrate, wherein the bonding braze material contains, as metal components, 0.5 to 4.0 parts by mass of at least one active metal selected from among titanium, zirconium, hafnium, and niobium, with respect to 100 parts by mass, in total, of 93.0 to 99.4 parts by mass of Ag, 0.1 to 5.0 parts by mass of Cu, and 0.5 to 2.0 parts by mass of Sn; and Cu-rich phases in a bonding braze material layer structure between the ceramic substrate and the metal plate have an average size of 3.5 ?m or less and a number density of 0.015/?m2 or higher. A method for producing a ceramic circuit substrate includes bonding at a temperature of 855 to 900° C. for a retention time of 10 to 60 minutes.