Abstract: A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.

Abstract: A compound that inhibits interaction between, murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.

Abstract: A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.

Abstract: A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.

Abstract: A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.

Abstract: In such a high lift twin-rudder system that: a pair of high lift rudders 1, 2 is arranged behind a single propeller 3; the respective high lift rudder 1, 2 has a top end plate 6, 7 and a bottom end plate 8, 9 at the top end and the bottom of a rudder blade 4, 5; the respective rudder blade 4, 5 is provided with a reaction fin 10, 11, protruding from an inboard face of the rudder blade 4, 5 on a nearly same level with the axis of the propeller 3, that is originated nearly from the leading edge portion toward the rear and has a fixed chord length; the reaction fin 10 of the rudder blade 4 that faces on the board-side where the propeller blades rotate in the ascending direction assumes a posture that makes such attack angle that the ratio of a forward vectored thrust to a drag, both produced by a propeller slip stream having a stream component in the ascending direction, becomes maximum; and the reaction fin 11 of the rudder blade 5 that faces on the board-side where the propeller blades rotate in the descending

Abstract: In such a high lift twin-rudder system that: a pair of high lift rudders 1, 2 is arranged behind a single propeller 3; the respective high lift rudder 1, 2 has a top end plate 6, 7 and a bottom end plate 8, 9 at the top end and the bottom of a rudder blade 4, 5; the respective rudder blade 4, 5 is provided with a reaction fin 10, 11, protruding from an inboard face of the rudder blade 4, 5 on a nearly same level with the axis of the propeller 3, that is originated nearly from the leading edge portion toward the rear and has a fixed chord length; the reaction fin 10 of the rudder blade 4 that faces on the board-side where the propeller blades rotate in the ascending direction assumes a posture that makes such attack angle that the ratio of a forward vectored thrust to a drag, both produced by a propeller slip stream having a stream component in the ascending direction, becomes maximum; and the reaction fin 11 of the rudder blade 5 that faces on the board-side where the propeller blades rotate in the descending