Patents by Inventor Takao Ikariya
Takao Ikariya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8344187Abstract: Esters and lactones can be respectively reduced to alcohols and diols in the presence of the Group 8 (VIII) transition metal complex, base and hydrogen gas (H2). An extremely practical reduction method can be provided by preferable combinations of the Group 8 (VIII) transition metal complex, the base, a used amount of the base, a pressure of hydrogen gas and a reaction temperature. This method is used in place of hydride reduction and is a useful method by which design of highly active catalysts can be relatively easily made while a high productivity can be expected.Type: GrantFiled: June 26, 2009Date of Patent: January 1, 2013Assignees: Tokyo Institute of Technology, Central Glass Company, LimitedInventors: Takao Ikariya, Masato Ito, Akira Shiibashi, Takashi Ootsuka
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Publication number: 20110092747Abstract: Esters and lactones can be respectively reduced to alcohols and diols in the presence of the Group 8 (VIII) transition metal complex, base and hydrogen gas (H2). An extremely practical reduction method can be provided by preferable combinations of the Group 8 (VIII) transition metal complex, the base, a used amount of the base, a pressure of hydrogen gas and a reaction temperature. This method is used in place of hydride reduction and is a useful method by which design of highly active catalysts can be relatively easily made while a high productivity can be expected.Type: ApplicationFiled: June 26, 2009Publication date: April 21, 2011Applicants: TOKYO INSTITUTE OF TECHNOLOGY, CENTRAL GLASS COMPANY, LIMITEDInventors: Takao Ikariya, Masato Ito, Akira Shiibashi, Takashi Ootsuka
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Patent number: 7332622Abstract: A process for preparing optically active nitro compounds and cyano compounds using a metal complex, which is obtained by reaction of an optically active nitrogen-containing compound and a periodic table group VIII metal complex, in the asymmetric Michael reaction.Type: GrantFiled: September 3, 2004Date of Patent: February 19, 2008Assignee: Kanto Kaguku Kabushiki KaishaInventors: Masahito Watanabe, Kunihiko Murata, Takao Ikariya
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Patent number: 7268250Abstract: A highly efficient process is provided for producing an optically active compound having high optical purity by an asymmetric reaction using as a catalyst a transition metal complex having an optically active nitrogen-containing compound as an asymmetric ligand.Type: GrantFiled: December 31, 2003Date of Patent: September 11, 2007Assignee: Kanto Kagaku Kabushiki KaishaInventors: Masahito Watanabe, Kunihiko Murata, Takao Ikariya
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Publication number: 20050101787Abstract: A process for preparing optically active nitro compounds and cyano compounds represented by the chemical formula (C) using a metal complex, which is obtained by reaction of an optically active nitrogen-containing compound and a periodic table group VIII metal complex, in the asymmetric Michael reaction of a compound represented by the chemical formula (A) and a compound represented by the chemical formula (B) according to the claim 1.Type: ApplicationFiled: September 3, 2004Publication date: May 12, 2005Applicant: Kanto Kagaku Kabushiki KaishaInventors: Masahito Watanabe, Kunihiko Murata, Takao Ikariya
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Patent number: 6887820Abstract: A method for producing optically active compounds is disclosed. The method is highly practical for producing optically active compounds useful for various utilities such as intermediates for synthesizing pharmaceutical agents, liquid crystal materials and agents for optical resolution.Type: GrantFiled: September 14, 2000Date of Patent: May 3, 2005Assignees: Japan Science and Technology Corporation, NKK Corporation, Takeda Pharmaceutical Company Limited, Asahi Kasei Pharma Corporation, Takasago International CorporationInventors: Takao Ikariya, Shohei Hashiguchi, Jun Takehara, Nobuyuki Uematsu, Kazuhiko Matsumura, Ryoji Noyori, Akio Fujii
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Patent number: 6888012Abstract: A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an ?-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.Type: GrantFiled: December 18, 2001Date of Patent: May 3, 2005Assignee: Ajinomoto Co., Inc.Inventors: Takayoshi Torii, Takayuki Hamada, Tomoyuki Onishi, Kunisuke Izawa, Takao Ikariya, Ryoji Noyori
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Patent number: 6790973Abstract: The invention provides novel ruthenium complexes having an optically active diphosphine compound, which has asymmetry on carbon and is easy to synthesize, as the ligand and a process for preparing optically active alcoholic compounds using said complexes as the catalysts, wherein said process is the process for preparing optically active alcoholic compounds, which are excellent in terms of reactivity, enatioselectivity and the like in an asymmetric hydrogenation of carbonyl compounds compared with conventional ruthenium complex catalysts having an optically active diphosphine compound having the axial chirality or the asymmetry on carbon as the ligand.Type: GrantFiled: December 27, 2002Date of Patent: September 14, 2004Assignee: Kanto Kagaku Kabushiki KaishaInventors: Kunihiko Tsutsumi, Kunihiko Murata, Takeshi Ota, Takao Ikariya
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Publication number: 20040176616Abstract: A highly efficient process is provided for producing an optically active compound having high optical purity by an asymmetric reaction using as a catalyst a transition metal complex having an optically active nitrogen-containing compound as an asymmetric ligand.Type: ApplicationFiled: December 31, 2003Publication date: September 9, 2004Applicant: KANTO KAGAKU KABUSHIKI KAISHAInventors: Masahito Watanabe, Kunihiko Murata, Takao Ikariya
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Publication number: 20040082820Abstract: A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an &agr;-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.Type: ApplicationFiled: June 25, 2003Publication date: April 29, 2004Inventors: Takayoshi Torii, Takayuki Hamada, Tomoyuki Onishi, Kunisuki Izawa, Takao Ikariya, Ryoji Noyori
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Patent number: 6686505Abstract: A process for producing an optically active amino alcohol is provided that includes a step in which a nitro ketone or a cyano ketone is reacted with a hydrogen-donating organic or inorganic compound in the presence of a transition metal compound catalyst having an optically active nitrogen-containing compound as an asymmetric ligand to give an optically active nitro alcohol or an optically active cyano alcohol, and a step in which the above optically active alcohol is further reduced to efficiently produce an optically active amino alcohol.Type: GrantFiled: October 31, 2002Date of Patent: February 3, 2004Assignee: Kanto Kaguku Kabushiki KaishaInventors: Masahito Watanabe, Kunihiko Murata, Takao Ikariya
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Publication number: 20030171592Abstract: A process for producing an optically active amino alcohol is provided that includes a step in which a nitro ketone or a cyano ketone is reacted with a hydrogen-donating organic or inorganic compound in the presence of a transition metal compound catalyst having an optically active nitrogen-containing compound as an asymmetric ligand to give an optically active nitro alcohol or an optically active cyano alcohol, and a step in which the above optically active alcohol is further reduced to efficiently produce an optically active amino alcohol.Type: ApplicationFiled: October 31, 2002Publication date: September 11, 2003Inventors: Masahito Watanabe, Kunihiko Murata, Takao Ikariya
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Publication number: 20030166978Abstract: The invention provides novel ruthenium complexes having an optically active diphosphine compound, which has asymmetry on carbon and is easy to synthesize, as the ligand and a process for preparing optically active alcoholic compounds using said complexes as the catalysts, wherein said process is the process for preparing optically active alcoholic compounds, which are excellent in terms of reactivity, enatioselectivity and the like in an asymmetric hydrogenation of carbonyl compounds compared with conventional ruthenium complex catalysts having an optically active diphosphine compound having the axial chirality or the asymmetry on carbon as the ligand.Type: ApplicationFiled: December 27, 2002Publication date: September 4, 2003Applicant: Kanto Kagaku Kabushiki KaishaInventors: Kunihiko Tsutsumi, Kunihiko Murata, Takeshi Ota, Takao Ikariya
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Patent number: 6476278Abstract: Alcohols are produced in a practical and advantageous method, by the hydrogenation of a carbonyl compound under mild conditions, by reacting the carbonyl compounds with hydrogen in the presence of a bipyridyl derivative, a group VIII transition metal complex, and a base, or by reducing a carbonyl compound in the presence of a bipyridyl derivative, a group VIII transition metal complex, a base, and an alcoholic solvent.Type: GrantFiled: October 25, 2001Date of Patent: November 5, 2002Assignees: Japan Science and Technology Corporation, Takasago International CorporationInventors: Hideyuki Ikehira, Kunihiko Murata, Eiji Katayama, Masami Kozawa, Toru Yokozawa, Takeshi Ohkuma, Takao Ikariya, Ryoji Noyori
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Patent number: 6323353Abstract: The invention provides a metal complex comprising a ligand and a metal. The ligand is an aminophosphine compound represented by the following formula (1) The metal is rhodium, ruthenium, iridium or nickel.Type: GrantFiled: December 23, 1999Date of Patent: November 27, 2001Assignee: Takasago International CorporationInventors: Kenzo Sumi, Ryoji Noyori, Takao Ikariya
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Patent number: 6184381Abstract: This document describes a novel and practically excellent process for the preparation of optically active compounds, such as optically active alcohols or amines which are useful for various applications, for example, as synthetic intermediates of pharmaceuticals, liquid crystal materials, and reagents for optical resolution, wherein a hydrogen transfer type asymmetric reduction is carried out in the presence of both a transition metal complex and an optically active nitrogen compound or a transition metal complex having an optically active nitrogen compounds as an asymmetric ligand, and a hydrogen-donating organic or inorganic compound.Type: GrantFiled: September 29, 1998Date of Patent: February 6, 2001Assignees: Japan Science & Technology Corp., NKK Corp., Takeda Chemical Industries, Asahi Kasei Kogyo Kabushiki Kaisha, Takasago Intl. Corp.Inventors: Takao Ikariya, Shohei Hashiguchi, Jun Takehara, Nobuyuki Uematsu, Kazuhiko Matsumura, Ryoji Noyori, Akio Fujii
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Patent number: 5869739Abstract: Formic acid or derivatives thereof are produced from non-toxic carbon dioxide in the supercritical state, using it as raw materials, without using solvents, and at a high efficiency owing to a high reaction velocity, by reacting said carbon dioxide and an active hydrogen group-containing compound.Type: GrantFiled: November 20, 1996Date of Patent: February 9, 1999Assignees: Research Development Corporation of Japan, NKK CorporationInventors: Takao Ikariya, Philip Gregory Jessop, Yi Hsiao, Ryoji Noyori
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Patent number: 5856590Abstract: A process whereby 4-t-butylcyclohexanol with a high content of the cis-isomer, which is useful as a perfume ingredient, can be economically produced on an industrially available scale at a low cost. The process comprises hydrogenating 4-t-butylcyclohexanone by using a specific ruthenium-phosphine complex as a catalyst in the presence of a base containing an alkali metal and an alkylenediamine having from 1 to 6 carbon atoms.Type: GrantFiled: March 7, 1997Date of Patent: January 5, 1999Assignee: Takasago International CorporationInventors: Makoto Emura, Takaaki Toyoda, Nobuo Seido, Ryoji Noyori, Takao Ikariya, Takeshi Ohkuma
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Patent number: 5824830Abstract: A novel ruthenium-phosphine complex useful as a catalyst for asymmetric hydrogenation is disclosed, which is represented by formula (I):{RuCl(R-BINAP)}{Ru(EtNH.sub.2)(R-BINAP)}(.mu.-Cl).sub.3 (I)wherein Et stands for an ethyl group; and R-BINAP represents a tertiary phosphine represented by formula (II): ##STR1## wherein R represents a hydrogen atom or a methyl group.Type: GrantFiled: August 12, 1997Date of Patent: October 20, 1998Assignee: Takasago International CorporationInventor: Takao Ikariya
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Patent number: 5763662Abstract: Formic acid or derivatives thereof are produced from non-toxic carbon dioxide in the supercritical state, using it as raw materials, without using solvents, and at a high efficiency owing to a high reaction velocity, by reacting said carbon dioxide and an active hydrogen group-containing compound.Type: GrantFiled: November 20, 1996Date of Patent: June 9, 1998Assignees: Research Development Corporation of Japan, NKK CorporationInventors: Takao Ikariya, Philip Gregory Jessop, Yi Hsiao, Ryoji Noyori