Abstract: A cortical spreading depolarization sensing method includes: acquiring, for each of a plurality of sites of the brain, waveform data indicating a temporal change in one or more types of biological information including at least any one of a direct current component of an electroencephalogram, hemoglobin concentration in the brain, cerebral blood flow, and brain temperature; determining windows set at predetermined time intervals on the waveform data and calculating a predetermined feature amount for each of the windows; performing threshold processing on the feature amounts to extract a timing of the occurrence of an event in which a value of the waveform data temporarily changes due to cortical spreading depolarization; acquiring the frequency distribution of the timings extracted based on the plurality of waveform data acquired in relation to a plurality of sites of the brain; and determining whether cortical spreading depolarization has occurred, based on the frequency distribution.

Abstract: An oil application device includes an oil supply member capable of selectively supplying oil to a first lateral surface and a second lateral surface of a flat wire. The oil supply member includes a first side surface and a second side surface. A part of the first side surface is a first application surface that is in contact with a part of the first lateral surface. Another part of the first side surface is a first non-application surface spaced apart from the first lateral surface. A part of the second side surface is a second application surface that is in contact with a part of the second lateral surface. Another part of the second side surface is a second non-application surface spaced apart from the second lateral surface.

Abstract: Disclosed are a bridged nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the formula (I) below. The bridged nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The bridged nucleoside also has excellent industrial productivity.

Abstract: A subdural sensor includes: a substrate formed of a flexible material; and at least one type of sensor part mounted on the substrate. The substrate has an elongated shape, and includes: a sensor area in which the sensor part is mounted and a wiring pattern connected to the sensor part is formed; a wiring area contiguous with the sensor area, the wiring pattern extending in the wiring area; and a connector area contiguous with the wiring area, the connector area being an area on which a connector to be connected to the wiring pattern extending from the wiring area is mounted. A tip part of the sensor area has a planar shape that curves convexly toward an outer periphery, and a side shape that curves toward a first surface, the first surface being on the side of a dura mater when the subdural sensor is inserted into the subdural space.

Abstract: A cross-linked nucleoside of the present invention is a compound represented by the formula (I) below. The cross-linked nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The cross-linked nucleoside also has excellent industrial productivity.

Abstract: An intravital cooling device is for cooling a target site in a living body and includes: a heat exchange part having a flow channel through which a refrigerant passes; and a flexible heat conduction sheet that is directly or indirectly connected to the heat exchange part and arranged to cover the target site, wherein the heat conduction sheet includes a living-body surface, which is a surface on the side that makes contact with the target site, and an outer surface, which is a surface opposite from the living-body surface.

Abstract: Disclosed are a 5?-modified nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the formula (I) below. The 5?-modified nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The 5?-modified nucleoside also has excellent industrial productivity because a diastereomer separation step is not involved in the production process thereof.

Abstract: The present invention aims to provide an antisense oligonucleic acid with reduced hepatotoxicity. The antisense oligonucleic acid according to the present invention is characterized in that it has a base length of not less than 7 nt and not more than 30 nt, wherein nucleic acid residues of not less than 1 nt and not more than 5 nt respectively from the both terminals are 2?,4?-bridged nucleic acids, 2?,4?-non-bridged nucleic acid residue(s) is(are) present between the above-mentioned both terminals, and one or more bases in the nucleic acid residue(s) of the above-mentioned 2?,4?-non-bridged nucleic acid residue(s) is/are modified.

Abstract: Disclosed are a 5?-modified nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the formula (I) below. The 5?-modified nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The 5?-modified nucleoside also has excellent industrial productivity because a diastereomer separation step is not involved in the production process thereof.

Abstract: An oil application device includes an oil supply member capable of selectively supplying oil to a first lateral surface and a second lateral surface of a flat wire. The oil supply member includes a first side surface and a second side surface. A part of the first side surface is a first application surface that is in contact with a part of the first lateral surface. Another part of the first side surface is a first non-application surface spaced apart from the first lateral surface. A part of the second side surface is a second application surface that is in contact with a part of the second lateral surface. Another part of the second side surface is a second non-application surface spaced apart from the second lateral surface.

Abstract: The present invention aims to provide an antisense oligonucleic acid with reduced hepatotoxicity. The antisense oligonucleic acid according to the present invention is characterized in that it has a base length of not less than 7 nt and not more than 30 nt, wherein nucleic acid residues of not less than 1 nt and not more than 5 nt respectively from the both terminals are 2?,4?-bridged nucleic acids, 2?,4?-non-bridged nucleic acid residue(s) is(are) present between the above-mentioned both terminals, and one or more bases in the nucleic acid residue(s) of the above-mentioned 2?,4?-non-bridged nucleic acid residue(s) is/are modified.

Abstract: A guide member includes a first diametrically directed side guide section and a second diametrically directed side guide section formed by bending a single member at a bent portion. The first diametrically directed side guide section guides predetermined portions of electric conductors on a diametrically directed side of a slot. Further, the second diametrically directed side guide section guides predetermined portions of the electric conductors on a diametrically directed side of another slot adjacent to the slot. The bent portion is supported by a supporting body.

Abstract: A positioning and fixing apparatus that fixes a position of a stator core includes a plurality of positioners that are displaced so as to approach or separate from the stator core, by a positioner displacing unit. One of the positioners is an engager that engages with a first tab section being an engaging section. First, the engager engages with the first tab section, and then, pressers being the remainder of the positioners position a certain region of the stator core.

Abstract: An insertion apparatus includes a conductor guide member that guides a prescribed region of an electric conductor to a slot of a stator core, and a support body that supports the conductor guide member. In this configuration, the conductor guide member can float in an axial direction of the stator core.

Abstract: An image forming apparatus according to an aspect of one or more embodiments may include: an image forming part that forms an image; a housing that houses the image forming part and includes an inner wall surface; and a cover attached to the housing so as to be movable between a position close to the housing and a position away from the housing. The cover includes a liquid receiver that receives a liquid getting into the housing, and the liquid receiver is adjacent to the inner wall surface in the state where the cover is close to the housing.

Abstract: A method for producing an insulated electric wire includes a step of preparing a conductor having a linear shape; a step of forming an insulating coating so as to cover a surface on an outer peripheral side of the conductor to obtain an insulated electric wire that includes the conductor and the insulating coating covering the conductor; and a step of measuring a first electrostatic capacity between the insulated electric wire and a first electrode disposed outside in a radial direction of the insulated electric wire so as to face an outer peripheral surface of the insulated electric wire while transporting the insulated electric wire in a longitudinal direction of the conductor, and inspecting a formation state of the insulating coating, the formation state including a formation state of a defective portion in the insulating coating, on the basis of a change in the first electrostatic capacity.

Abstract: An insertion apparatus includes a conductor guide member that guides a prescribed region of an electric conductor to a slot of a stator core, and a support body that supports the conductor guide member. In this configuration, the conductor guide member can float in an axial direction of the stator core.

Abstract: A positioning and fixing apparatus that fixes a position of a stator core includes a plurality of positioners that are displaced so as to approach or separate from the stator core, by a positioner displacing unit. One of the positioners is an engager that engages with a first tab section being an engaging section. First, the engager engages with the first tab section, and then, pressers being the remainder of the positioners position a certain region of the stator core.