Patents by Inventor Takao Nagoya
Takao Nagoya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6828316Abstract: The present invention relates to diamide derivatives represented by the following general formula (1): wherein A is a phenyl group or the like, which may be substituted, B is —CH═CH—, —C≡C—, —(CH═CH)2—, —C≡C—CH═CH—, —CH═CH—C≡C—, phenylene or the like, and W is and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.Type: GrantFiled: October 17, 2001Date of Patent: December 7, 2004Assignee: Kowa Co., Ltd.Inventors: Hiroyuki Ishiwata, Mototsugu Kabeya, Hiromichi Shigyo, Masami Shiratsuchi, Yukio Hattori, Hiroshi Nakao, Takao Nagoya, Seiichi Sato, Soichi Oda, Makoto Suda, Manabu Shibasaki
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Patent number: 6645957Abstract: The invention relates to compounds represented by the following general formula (1): wherein A is an aromatic compound which may be substituted, or the like, B is a nitrogen atom or CH, X is a lower alkylene group which may be substituted, or the like, Y is a single bond or the like; Z is a divalent residue of benzene which may be substituted, or the like, and m and n are independently an integer of 1 to 4, and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.Type: GrantFiled: June 19, 2002Date of Patent: November 11, 2003Assignee: Kowa Co., Ltd.Inventors: Hiroyuki Ishiwata, Seiichi Sato, Mototsugu Kabeya, Soichi Oda, Yukio Hattori, Makoto Suda, Manabu Shibasaki, Hiroshi Nakao, Takao Nagoya
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Patent number: 6576642Abstract: Compounds having the formula (1): wherein A is a phenyl, naphthyl, dihydronaphthyindeny, pyridyl, indolyl,isoindolyl, quinolyl or isoquinolyl group which are optionally substituted; X is optionally substituted alicyclic, aromatic, imino or heterocyclic groups or —S— or —O—; Y is a single bond or an alkylene group; Z is an unsubstituted aliphatic group or divalent residue of benzene or pyridine, which is optionally substituted; anis hydrogen, lower alkyl, cycloalkyl, aryl or aralkyl; with certain provisos. These compounds exhibit an inhibitory effect on the production of IgE antibodies and are, hence, useful as antiallergic agents.Type: GrantFiled: May 17, 2001Date of Patent: June 10, 2003Assignee: Kowa Co., Ltd.Inventors: Hiroyuki Ishiwata, Mototsugu Kabeya, Masami Shiratsuchi, Yukio Hattori, Hiroshi Nakao, Takao Nagoya, Seiichi Sato, Soichi Oda, Makoto Suda, Manabu Shibasaki
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Publication number: 20030096828Abstract: The invention relates to compounds represented by the following general formula (1): 1Type: ApplicationFiled: June 19, 2002Publication date: May 22, 2003Applicant: KOWA CO., LTD.Inventors: Hiroyuki Ishiwata, Seiichi Sato, Mototsugu Kabeya, Soichi Oda, Yukio Hattori, Makoto Suda, Manabu Shibasaki, Hiroshi Nakao, Takao Nagoya
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Patent number: 6448242Abstract: The invention relates to compounds represented by the following general formula (1): wherein A is an aromatic compound which may be substituted, or the like, B is a nitrogen atom or CH, X is a lower alkylene group which may be substituted, or the like, Y is a single bond or the like; Z is a divalent residue of benzene which may be substituted, or the like, and m and n are independently an integer of 1 to 4, and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.Type: GrantFiled: August 21, 2000Date of Patent: September 10, 2002Assignee: Kowa Co., Ltd.Inventors: Hiroyuki Ishiwata, Seiichi Sato, Mototsugu Kabeya, Soichi Oda, Yukio Hattori, Makoto Suda, Manabu Shibasaki, Hiroshi Nakao, Takao Nagoya
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Publication number: 20020042414Abstract: The present invention relates to diamide derivatives represented by the following general formula (1): 1Type: ApplicationFiled: October 17, 2001Publication date: April 11, 2002Applicant: KOWA CO., LTD.Inventors: Hiroyuki Ishiwata, Mototsugu Kabeya, Hiromichi Shigyo, Masami Shiratsuchi, Yukio Hattori, Hiroshi Nakao, Takao Nagoya, Seiichi Sato, Soichi Oda, Makoto Suda, Manabu Shibasaki
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Patent number: 6340682Abstract: The present invention provides diamide derivatives represented by the following general formula (1): wherein A is a phenyl group or the like, which may be substituted, B is —CH═CH—, —C═C—, —(CH═CH)2—, —C≡C—CH═CH—, —CH═CH—C≡C—, phenylene or the like, and W is or and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.Type: GrantFiled: February 23, 1999Date of Patent: January 22, 2002Assignee: Kowa Co., Ltd.Inventors: Hiroyuki Ishiwata, Mototsugu Kabeya, Hiromichi Shigyo, Masami Shiratsuchi, Yukio Hattori, Hiroshi Nakao, Takao Nagoya, Seiichi Sato, Soichi Oda, Makoto Suda, Manabu Shibasaki
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Publication number: 20010039279Abstract: The present invention relates to compounds represented by the following general formula (1): 1Type: ApplicationFiled: May 17, 2001Publication date: November 8, 2001Applicant: KOWA CO., LTD.Inventors: Hiroyuki Ishiwata, Mototsugu Kabeya, Masami Shiratsuchi, Yukio Hattori, Hiroshi Nakao, Takao Nagoya, Seiichi Sato, Soichi Oda, Makoto Suda, Manabu Shibasaki
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Patent number: 6297283Abstract: The present invention relates to compounds represented by the following general formula (1): wherein A is a phenyl, naphthyl, dihydronaphthyl, indenyl, pyridyl, indolyl, isoindolyl, quinolyl or isoquinolyl group which may be substituted; X is a lower alkylene group which may be substituted, or the like; Y is a single bond or an alkylene group; Z is a group of —CH═CH—, —C≡C—, —(CH═CH)2—, —C≡C—CH═CH— or —CH═CH—C≡C—, or the like; and R is a hydrogen atom, a lower alkyl group or the like, and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.Type: GrantFiled: April 9, 1999Date of Patent: October 2, 2001Assignee: Kowa Co., Ltd.Inventors: Hiroyuki Ishiwata, Mototsugu Kabeya, Masami Shiratsuchi, Yukio Hattori, Hiroshi Nakao, Takao Nagoya, Seiichi Sato, Soichi Oda, Makoto Suda, Manabu Shibasaki
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Patent number: 5723465Abstract: The present invention is directed to a cell adhesion inhibitory agent, cellular infiltration inhibitory agent, antiallergic agent, antiasthmatic agent, and antiphlogistic, which contains a compound of the following formula (1): ##STR1## wherein each of R.sup.1 through R.sup.6 represents H, a halogen atom, a hydroxyl group, a lower alkyl group, or a lower alkoxy group, m represents a number of 1 from 3 inclusive, and n represents 2 or 3.Type: GrantFiled: November 18, 1996Date of Patent: March 3, 1998Assignee: Kowa Co., Ltd.Inventors: Hiroshi Nakao, Michihisa Umetani, Makoto Suda, Takao Nagoya
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Patent number: 5360789Abstract: A therapeutic agent for skin or corneal diseases containing CPB-I (calphobindin-I) or recombinant CPB-I as the active ingredient. The CPB-I or recombinant CPB-I have excellent activities in promoting regeneration of granulation tissue, migration of corneal endothelial and epithelial cells, etc., and lowering PKC activity. Because the agent has an action mechanism different from that of the conventional agent, it can be used together with the conventional agent to enhance the therapeutic effect, thus being remarkably useful for treating all sorts of the skin and corneal diseases, in particular, wound and psoriasis.Type: GrantFiled: May 20, 1993Date of Patent: November 1, 1994Assignee: Kowa Co., Ltd.Inventors: Hiroshi Nakao, Takao Nagoya, Yushi Saino
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Patent number: 5290915Abstract: A monoclonal antibody specific to a human placenta-derived coagulation inhibitor is disclosed. The antibody is produced by culturing a hybridoma which secretes it. A human placenta-derived coagulation inhibitor can be purified by using the monoclonal antibody as an immunoadsorbent. The human placenta-derived coagulation inhibitor can be immunologically assayed by using the monoclonal antibodies.Type: GrantFiled: January 13, 1992Date of Patent: March 1, 1994Assignee: Kowa Co., Ltd.Inventors: Hiroshi Nakao, Takao Nagoya, Yushi Saino, Masahiro Maki, Hideo Tani
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Patent number: 5192694Abstract: A monoclonal antibody specific to a human placenta-derived coagulation inhibitor is disclosed. The antibody is produced by culturing a hybridoma which secretes it. A human placenta-derived coagulation inhibitor can be purified by using the monoclonal antibody as an immunoadsorbent. The human placenta-derived coagulation inhibitor can be immunologically assayed by using the monoclonal antibodies.Type: GrantFiled: November 5, 1987Date of Patent: March 9, 1993Assignee: Kowa Co., Ltd.Inventors: Hiroshi Nakao, Takao Nagoya, Yushi Saino
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Patent number: 5098829Abstract: The present invention provides a monoclonal antibody specific to a thrombin-binding substance (TM), hybridomas producing the monoclonal antibody, a purification process of TM featuring the use of the monoclonal antibody as an immunoadsorbent, as well as an immunoassay of TM featuring the use of the monoclonal antibody.Type: GrantFiled: July 30, 1990Date of Patent: March 24, 1992Assignee: Kowa Co., Ltd.Inventors: Nobuo Aoki, Takao Nagoya, Shigeru Kimura