Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A large current electron beam is stably emitted from an electron gun of a charged particle beam device. The electron gun of the charged particle beam device includes: a SE tip 202; a suppressor 303 disposed rearward of a distal end of the SE tip; a cup-shaped extraction electrode 204 including a bottom surface and a cylindrical portion and enclosing the SE tip and the suppressor; and an insulator 208 holding the suppressor and the extraction electrode. A shield electrode 301 of a conductive metal having a cylindrical portion 302 is provided between the suppressor and the cylindrical portion of the extraction electrode. A voltage lower than a voltage of the SE tip is applied to the shield electrode.

Abstract: A door structure includes a door panel, a first beam member, a first bracket attached to a rear end portion of the first beam member, a second beam member formed separately from the first beam member, a second bracket attached to a rear end portion of the second beam member and formed separately from the first bracket, and a coupling member, to which the first bracket and the second bracket are fixed to be arranged side by side, and which is attached to the door panel. The coupling member includes an extending portion extending in a vehicle width direction between the first bracket and the second bracket.

Abstract: A door structure includes a door panel, a first beam member, a first bracket attached to a rear end portion of the first beam member, a second beam member formed separately from the first beam member, a second bracket attached to a rear end portion of the second beam member and formed separately from the first bracket, and a coupling member, to which the first bracket and the second bracket are fixed to be arranged side by side, and which is attached to the door panel. The coupling member includes an extending portion extending in a vehicle width direction between the first bracket and the second bracket.

Abstract: A colorant for plastic containing a halogenated phthalocyanine pigment (A) that satisfies conditions (1) to (4) below: (1) the average number of halogen substitutions is at least 2.0 but not more than 7.0, (2) the halogen distribution width is at least 5, (3) the amount of aluminum phthalocyanine and halogenated aluminum phthalocyanine is not more than 1.0% by mass, and (4) the central element is at least one element selected from the group consisting of hydrogen, manganese, iron, cobalt, zinc, nickel and copper. As a result, a colorant for plastic can be shown that can color a resin without changing the mechanical or chemical properties of the resin, and in particular can produce a plastic molded article having essentially no migration, extremely low discoloration due to heat, and no deformation such as warping and distortion.

Abstract: The present invention provides an apparatus for acquiring data for designing a last capable of accurately measuring a three-dimensional shape of a sole of a foot that is curved as if a footwear is being worn thereon. The apparatus for acquiring data for designing a last includes a placement section 2 for placing feet F and F? thereon and an imaging means 3 arranged around the placement section 2. The placement section 2 includes a heel rest 12 for placing the heel of the foot F or the foot F? thereon, thereby enabling accurate measurement of the data of the sole that is curved in such a state as if footwear having a heel such as a pump is being worn thereon, without moving the foot during the measurement.

Abstract: An eddy-current flaw detector includes a trace data calculator configured to calculate each coordinate with respect to flaw detection points on which an inspection probe is used upon performing an eddy-current testing based on an inputted condition of eddy-current flaw detection and surface shape data of an inspection-object surface measured by a profilometer, and to calculate a normal vector of each flaw detection point; a gap evaluation calculator configured to acquire an evaluation result on a gap between the inspection-object surface and the inspection probe for each flaw detection point; a flaw detection data collector configured to acquire flaw detection data of an inspection object for each flaw detection point; a flaw detection data analyzer configured to evaluate presence/absence of a flaw in the inspection-object surface based on the flaw detection data of the inspection object and the evaluation result on the gap for each flaw detection point.

Abstract: A method for producing a halogenated organic pigment comprising a halogenation step of halogenating an organic pigment with a halogenating agent, wherein the halogenating agent comprises one or more N-haloimide compounds selected from the group consisting of trichloroisocyanuric acid, a metal salt of dichloroisocyanuric acid, tribromoisocyanuric acid, and a metal salt of dibromoisocyanuric acid. According to the present invention, a method for producing a halogenated organic pigment which does not use high toxic raw materials, does not generate a large amount of unfavorable by-products such as hydrogen halide gas and succinimide, and is excellent in terms of safety and productivity can be provided.

Abstract: An eddy-current flaw detector includes a trace data calculator configured to calculate each coordinate with respect to flaw detection points on which an inspection probe is used upon performing an eddy-current testing based on an inputted condition of eddy-current flaw detection and surface shape data of an inspection-object surface measured by a profilometer, and to calculate a normal vector of each flaw detection point; a gap evaluation calculator configured to acquire an evaluation result on a gap between the inspection-object surface and the inspection probe for each flaw detection point; a flaw detection data collector configured to acquire flaw detection data of an inspection object for each flaw detection point; a flaw detection data analyzer configured to evaluate presence/absence of a flaw in the inspection-object surface based on the flaw detection data of the inspection object and the evaluation result on the gap for each flaw detection point.

Abstract: A colorant for plastic containing a halogenated phthalocyanine pigment (A) that satisfies conditions (1) to (4) below: (1) the average number of halogen substitutions is at least 2.0 but not more than 7.0, (2) the halogen distribution width is at least 5, (3) the amount of aluminum phthalocyanine and halogenated aluminum phthalocyanine is not more than 1.0% by mass, and (4) the central element is at least one element selected from the group consisting of hydrogen, manganese, iron, cobalt, zinc, nickel and copper. As a result, a colorant for plastic can be shown that can color a resin without changing the mechanical or chemical properties of the resin, and in particular can produce a plastic molded article having essentially no migration, extremely low discoloration due to heat, and no deformation such as warping and distortion.

Abstract: A method for producing a halogenated organic pigment comprising a halogenation step of halogenating an organic pigment with a halogenating agent, wherein the halogenating agent comprises one or more N-haloimide compounds selected from the group consisting of trichloroisocyanuric acid, a metal salt of dichloroisocyanuric acid, tribromoisocyanuric acid, and a metal salt of dibromoisocyanuric acid. According to the present invention, a method for producing a halogenated organic pigment which does not use high toxic raw materials, does not generate a large amount of unfavorable by-products such as hydrogen halide gas and succinimide, and is excellent in terms of safety and productivity can be provided.

Abstract: A door assembly (40) for a vehicle, including a vehicle door (12) for opening and closing a door opening in the vehicle body. The door comprises a door body (15), an outer cover member (27) which covers at least a part of the outer surface (53) of the door outer panel (21) of the door body, and a seal member (28). The outer cover member comprises an outer cover body (165) which covers the outer surface of the door outer panel, an extension section (164) which is extended further toward the outside than an edge (163) of the door body, and a closed cross-section section (166) which is formed in a closed cross-sectional shape on the rear surface (177) of the extension section. The seal member is attached to the closed cross-section section.

Abstract: A door assembly (40) for a vehicle, including a vehicle door (12) for opening and closing a door opening in the vehicle body. The door comprises a door body (15), an outer cover member (27) which covers at least a part of the outer surface (53) of the door outer panel (21) of the door body, and a seal member (28). The outer cover member comprises an outer cover body (165) which covers the outer surface of the door outer panel, an extension section (164) which is extended further toward the outside than an edge (163) of the door body, and a closed cross-section section (166) which is formed in a closed cross-sectional shape on the rear surface (177) of the extension section. The seal member is attached to the closed cross-section section.

Abstract: A headrest of a head protective type including a trim cover assembly having: a head receiving area against which a head of rear-seat occupant is to be struck in a collision case; and an impact absorbing frame disposed within the trim cover assembly. A reinforcing element is provided to an inner surface of the trim cover assembly at a point corresponding to such head receiving area, thereby preventing breakage of the trim cover assembly in the case where the head of rear-seat occupant is struck against that head receiving area.

Abstract: A method of assembling a vehicle seat by bonding adhesively a trim cover assembly to a preformed foam cushion member. In the assemblage, a location board having a serrated part on its side is sewn to the trim cover assembly such that the serrated part projects from the reverse surface of cover assembly, and such assembly is turned over and placed on a lower die having a location groove which includes a vertically curved part. The location board is fitted and bent vertically along such location groove, which permits bonding of the cover assembly neatly over the uneven surface of cushion member, without slack and wrinkles, when pressing the cushion member against the cover assembly by means of an upper die.