Abstract: Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.

Abstract: According to the present invention, in a method for subjecting a roughly ground chamfer portion of a semiconductor wafer to helical grinding by relatively inclining the wafer and a second grinding stone to perform precise grinding, an edge portion of a discoid truer is formed into a vertically asymmetrical groove shape of a first grinding stone by using the first grinding stone having a vertically asymmetrical groove formed on a periphery thereof to grind the edge portion of the truer by the groove of the first grinding stone without being relatively inclined, a groove is formed on a periphery of the second grinding stone by relatively inclining the truer and the second grinding stone to subject the second grinding stone to helical grinding, and the chamfer portion of the wafer is precisely ground based on helical grinding by relatively inclining the semiconductor wafer with respect to a direction of the groove formed on the periphery of the second grinding stone.

Abstract: An electronic cooling apparatus has a cabinet which is open at the front and rear sides thereof and accommodates plural electronic devices each having a fan, and a rear door which is provided with an evaporator. Air blown by the fan is cooled by the evaporator and then returned to a room. An expansion valve and control. A drain pan with an extension portion having hole portions through which refrigerant pipes extend is provided. A drain hose discharges drain water from the drain pan. An exhaust heat temperature detecting unit and a control for controlling the refrigerant supply to the evaporator are provided. When the exhaust heat temperature is equal to or less than a set exhaust temperature, the controller stops the refrigerant supply to the evaporator. When the exhaust heat temperature exceeds the set temperature, the controller starts the refrigerant supply.

Abstract: An air conditioner having a heat-source side unit including a compressor and a heat-source side heat exchanger, plural use-side units each having a use-side heat exchanger and an inter-unit pipe for connecting the heat-source side unit to the plural use-side units, including an auxiliary heat source unit having a water-refrigerant heat exchanger for heat-exchanging refrigerant with water, a refrigerant side of the water-refrigerant heat exchanger being selectively connectable to one of the high-pressure gas pipe and the low-pressure gas pile through one of a first change-over valve and a second change-over valve, and also connected to a liquid pipe through an expansion valve, and a controller for controlling the auxiliary heat source unit so that the water-refrigerant heat exchanger of the auxiliary heat source unit functions as an evaporator with a water side thereof serving as a heat source when some of the user-side units are under heating operation.

Abstract: A novel organic anion transporter gene participating in organic anion transport in the placenta; and an organic anion transporter which is a polypeptide encoded by the gene. A placental organic anion transporter OAT4, more particularly, a placental organic anion transporter OAT4 having the amino acid sequence represented by SEQ ID NO:2 or an amino acid sequence derived therefrom by deletion, substitution or addition of a part of the amino acids thereof. A nucleic acid (preferably DNA) having a base sequence encoding the placental organic anion transporter OAT4 or a base sequence hybridizable therewith under stringent conditions.

Abstract: An electrical connector assembly comprises a flexible flat cable and a coupler. The flexible flat cable has a tip. A plurality of conductors is provided on a section of the tip between ends thereof. The coupler includes a first holding member mated with a second holding member. The flexible flat cable is positioned between the first and second holding members. The coupler is arranged behind the tip such that both sides of the tip are exposed. The coupler has a width longer than the section of the tip provided with the conductors.

Abstract: An electrical connector assembly comprises a flexible flat cable and a coupler. The flexible flat cable has a tip. A plurality of conductors is provided on a section of the tip between ends thereof. The coupler includes a first holding member mated with a second holding member. The flexible flat cable is positioned between the first and second holding members. The coupler is arranged behind the tip such that both sides of the tip are exposed. The coupler has a width longer than the section of the tip provided with the conductors.

Abstract: A protein capable of transporting organic anions having amino acid sequences represented by SEQ ID NO: 1 or 2 or amino acid sequences derived therefrom by deletion, substitution or addition of one or more amino acid residues; and a gene coding for the protein. The protein and gene therefor are useful in vitro analysis of drug release and drug-drug interactions and development of methods for screening drugs useful for preventing nephrotoxicity.

Abstract: A protein capable of transporting organic anions having amino acid sequences represented by SEQ ID NO: 1 or 2 or amino acid sequences derived therefrom by deletion, substitution or addition of one or more amino acid residues; and a gene coding for the protein. The protein and gene therefore are useful in vitro analysis of drug release and drug—drug interactions and development of method for screening drugs useful for preventing nephrotoxicity.

Abstract: A novel organic anion transporter gene participating in organic anion transport in the placenta; and an organic anion transporter which is a polypeptide encoded by the gene. A placental organic anion transporter OAT4, more particularly, a placental organic anion transporter OAT4 having the amino acid sequence represented by SEQ ID NO:2 or an amino acid sequence derived therefrom by deletion, substitution or addition of a part of the amino acids thereof. A nucleic acid (preferably DNA) having a base sequence encoding the placental organic anion transporter OAT4 or a base sequence hybridizable therewith under stringent conditions.

Abstract: A novel organic anion transporter gene participating in organic anion transport in the placenta; and an organic anion transporter which is a polypeptide encoded by the gene. A placental organic anion transporter OAT4, more particularly, a placental organic anion transporter OAT4 having the amino acid sequence represented by SEQ ID NO:2 or an amino acid sequence derived therefrom by deletion, substitution or addition of a part of the amino acids thereof. A nucleic acid (preferably DNA) having a base sequence encoding the placental organic anion transporter OAT4 or a base sequence hybridizable therewith under stringent conditions.

Abstract: Disclosed are a clear aqueous solution of diclofenac sodium dissolved in a mixed solvent of a fatty acid dialkylolamide and water; an anti-inflammatory analgesic composition excellent in percutaneous absorption, which comprises the clear aqueous solution and a higher unsaturated aliphatic alcohol contained in the solution; and a self-adhesive cataplasm comprising a cataplasm base and the clear aqueous solution, polybutene and gelatin added in the base. The clear aqueous solution of diclofenac sodium contains, in particular, diclofenac sodium, a fatty acid dialkylolamide and water at a ratio falling within a hexagonal region formed by linking the points A, B, C, D, E and F in the figure.

Abstract: Disclosed is a medicinal composition, which comprises a peptide as an effective ingredient and as bases, epsilon aminocaproic acid or tranexamic acid and an ethylene oxide-propylene oxide block copolymer represented by the following formula (I):HO(C.sub.2 H.sub.4 O).sub.a --(C.sub.3 H.sub.6 O).sub.b --(C.sub.2 H.sub.4 O).sub.c H (I)wherein a, b and c stand for integers of 1 or greater, respectively. According to this medicinal composition, the peptide can be absorbed at a high rate through the mucosa and further, its pharmacological effects are prolonged over for a long time.

Abstract: Disclosed herein is an external preparation composition, in a liquid preparation, cream, ointment or cataplasm plaster, characterized in that the composition contains a water-soluble salt of diclofenac, such as diclofenac sodium, water, and a fatty acid dialkylolamide and/or its polyoxyethylene adduct.The external preparation composition according to this invention is excellent in the percutaneous absorption of the water-soluble salt of diclofenac, which has high solubility and stability in the preparation.

Abstract: A reflection-type overhead projector for projecting large transparencies onto a remote screen. The overhead projector has a base with a Fresnel mirror that serves as a stage on which a transparency to be projected is placed, and a lamp housing for a projection lens with an associated mirror which is supported on a pivotable arm above the base. The lamp housing is formed with an opening for allowing the passage of light to illuminate the transparency on the stage. This opening is fitted with a protective screen for guarding the fingers from the heated illumination lamp.

Abstract: A fuel assembly has a plurality of fuel rods arranged and held in parallel with one another in the cells of spacer assemblies arranged at suitable intervals. During the assemblying and transportation of the fuel assembly, flexible sleeves are inserted in respective cells such as to separate the fuel rods from parts provided on the walls of the cells, thereby protecting the fuel rod surfaces against any damage and scratch which may otherwise be caused due to interference between the fuel rod surface and the parts provided on the walls of the cell.

Abstract: In a valve unit provided with a straight-cylindrical valve housing having a thick barrel portion and a thin head portion; an inward-facing valve seat on the upper edge of the head portion; and an upper edge on the head of an internal valve element, the upper edge engages the inward-facing valve seat when a lower passage in the valve housing is defined.

Abstract: A chemical analyzer in which a component of a material to be analyzed acts on a coloring (dye forming) reagent in a reagent layer of the multi-layer type chemical analysis slide. The material to be analyzed is then maintained at a constant temperature for a predetermined period of time, after which the degree of coloration thereof is measured optically so that predetermined parameters of the material are measured with a very high accuracy. A conveying mechanism conveys the chemical analysis slides along an analysis path between two stationary temperature control plates. A first one of the plates having a cut therein has a heating element buried therein extending throughout the plate. The opposed plate has a heating element extending into regions not opposed by the cut in the first plate. The second plate has plural openings through which an irradiating light beam from a light source of a photometric mechanism and a reflection light beam from slides positioned over the openings pass.