Abstract: An endoscope includes an image pick-up-device at a distal-end-part of an insertion-part. The image pick-up-device includes a lens barrel holding an imaging lens; an image-sensor having a rectangular shape as an outer peripheral shape of an image reception surface on which imaging light incident via the imaging lens; and a sensor holder holding the image-sensor in a state where the image reception surface intersects a longitudinal direction of the insertion-part. The sensor holder has three independent wall-parts respectively covering three side surfaces of the image-sensor, and on an XY plane orthogonal to the longitudinal direction of the insertion-part, a gap length, in an X-axis direction on the plane between adjacent wall-parts of the three wall-parts and a gap length, in Y-axis direction, between the adjacent wall-parts are equal to each other. Additionally, the height of each of the three wall-parts is 1.5 times to 3 times the gap length.

Abstract: An object of the present invention is to provide a compound, a method and a pharmaceutical composition for normalizing double homeobox 4 (DUX4) of an individual in which the DUX4 gene has abnormally expressed. Provided is a modified oligonucleotide consisting of 12-30 residues. The modified oligonucleotide includes a nucleobase sequence that includes at least 8 contiguous nucleobase sequences and is complementary to an equal length portion at positions 126-147, 232-248, 1306-1325 or 1472-1495 from a 5? end of a nucleobase of a mature mRNA of DUX4 of SEQ ID NO: 1. The nucleobase sequence of the modified oligonucleotide has at least 90% complementarity to the equal length portion in the nucleobase sequence of the mature mRNA of DUX4 of SEQ ID NO: 1.

Abstract: An endoscope includes an image pick-up device at a distal end part of an insertion part capable of being inserted into a body cavity. The image pick-up device includes a lens barrel that holds an imaging lens; an image sensor having a rectangular shape as an outer peripheral shape of the image reception surface on which imaging light incident via the imaging lens; and a sensor holder that holds the image sensor in a state where the image reception surface intersects a longitudinal direction of the insertion part. The sensor holder has a fitting part fitted to the lens barrel, and an extending wall part that extends in the longitudinal direction of the insertion part from the fitting part to cover at least a portion of the outer peripheral surface of the image sensor, and the fitting part and the extending wall part are integrally configured.

Abstract: An endoscope system includes: an endoscope including a side-viewing observation unit that includes a field of view in a lateral direction of an insertion part to be inserted into an object to be observed and a second protruding portion that protrudes from the insertion part and forms a blind spot in the field of view of the side-viewing observation unit; an image acquisition unit that acquires a side-viewing observation image by using the side-viewing observation unit; a monitor that displays the side-viewing observation image; and a display control section that allows at least a part of the blind spot of the side-viewing observation image in which the second protruding portion is shown up not to be displayed, and displays the side-viewing observation image on the monitor.

Abstract: An endoscope includes an image pick-up device at a distal end part of an insertion part capable of being inserted into a body cavity. The image pick-up device includes a lens barrel that holds an imaging lens; an image sensor having a rectangular shape as an outer peripheral shape of the image reception surface on which imaging light incident via the imaging lens; and a sensor holder that holds the image sensor in a state where the image reception surface intersects a longitudinal direction of the insertion part. The sensor holder has a fitting part fitted to the lens barrel, and an extending wall part that extends in the longitudinal direction of the insertion part from the fitting part to cover at least a portion of the outer peripheral surface of the image sensor, and the fitting part and the extending wall part are integrally configured.

Abstract: An endoscope includes an image pick-up-device at a distal-end-part of an insertion-part. The image pick-up-device includes a lens barrel holding an imaging lens; an image-sensor having a rectangular shape as an outer peripheral shape of an image reception surface on which imaging light incident via the imaging lens; and a sensor holder holding the image-sensor in a state where the image reception surface intersects a longitudinal direction of the insertion-part. The sensor holder has three independent wall-parts respectively covering three side surfaces of the image-sensor, and on an XY plane orthogonal to the longitudinal direction of the insertion-part, a gap length, in an X-axis direction on the plane between adjacent wall-parts of the three wall-parts and a gap length, in Y-axis direction, between the adjacent wall-parts are equal to each other. Additionally, the height of each of the three wall-parts is 1.5 times to 3 times the gap length.

Abstract: An endoscope includes in a tip portion of an insertion unit: an image sensor having plural terminals including a video terminal which outputs a video signal; and a tip potion of a treatment tool channel which extends in a longitudinal direction of the insertion unit, and a distance of the video terminal is longest among distances of the respective terminals from a center of the treatment tool channel in a plane that is perpendicular to the longitudinal axis.

Abstract: An endoscope includes, in a tip portion of an insertion unit: an image sensor having a photodetecting surface as defined herein; an imaging optical system as defined herein; a holding frame as defined herein; and a tip portion of a treatment tool channel as defined herein, and, in a cross section taken perpendicularly to the optical axis, a thickness, on a first axis that intersects the optical axis and a center of the treatment tool channel, of frame wall portions, located on two respective sides of the optical axis and intersecting the first axis, of at least a portion of the holding frame is smaller than a thickness, on a second axis that is perpendicular to the optical axis and the first axis, of frame wall portions, located on two respective sides of the optical axis and intersecting the second axis, of the at least portion of the holding frame.

Abstract: An endoscope includes an image sensor that is provided at a front end portion of an insertion portion of the endoscope so that an image receiving surface of the image sensor is disposed to cross a longitudinal axis of the insertion portion; a sensor holder that surrounds an outer circumference of the image sensor and holds the image sensor; and a circuit board including a sensor connection portion and an electric wire connection portion as defined herein; the image sensor is held by the sensor holder as defined herein; the sensor connection portion and the electric wire connection portion are connected to each other as defined herein; and an outside edge of a connection site between the sensor connection portion and the electric wire connection portion is located as defined herein.

Abstract: An endoscope system includes: an endoscope including a side-viewing observation unit that includes a field of view in a lateral direction of an insertion part to be inserted into an object to be observed and a second protruding portion that protrudes from the insertion part and forms a blind spot in the field of view of the side-viewing observation unit; an image acquisition unit that acquires a side-viewing observation image by using the side-viewing observation unit; a monitor that displays the side-viewing observation image; and a display control section that allows at least a part of the blind spot of the side-viewing observation image in which the second protruding portion is shown up not to be displayed, and displays the side-viewing observation image on the monitor.

Abstract: An image pickup optical system of an endoscope includes: a first optical member group that includes an objective optical member disposed closest to a subject side and an image-side optical member that is disposed adjacent to an image side of the objective optical member; a first lens barrel that holds the first optical member group; a second optical member group that is disposed on an image side of the first optical member group; and a second lens barrel that holds the second optical member group, as defined herein.

Abstract: Realized is a vehicle seat capable of improving the rigidity of a cushion frame with respect to a load input to a seat back while suppressing an increase in weight and size of the cushion frame. In a vehicle seat including a height adjustment mechanism which is driven to adjust the height of a seat cushion and a brake mechanism which maintains the height of the seat cushion when the height adjustment mechanism is not driven, the brake mechanism is connected to a second connection portion different from a first connection portion connected to the seat back in the cushion frame, and reinforcement portions and which extend in a direction from the first connection portion toward the second connection portion are provided between the first connection portion and the second connection portion in the cushion frame.

Abstract: An endoscope includes an image sensor that is provided at a front end portion of an insertion portion of the endoscope so that an image receiving surface of the image sensor is disposed to cross a longitudinal axis of the insertion portion; a sensor holder that surrounds an outer circumference of the image sensor and holds the image sensor; and a circuit board including a sensor connection portion and an electric wire connection portion as defined herein; the image sensor is held by the sensor holder as defined herein; the sensor connection portion and the electric wire connection portion are connected to each other as defined herein; and an outside edge of a connection site between the sensor connection portion and the electric wire connection portion is located as defined herein.

Abstract: An endoscope includes, in a tip portion of an insertion unit: an image sensor having a photodetecting surface as defined herein; an imaging optical system as defined herein; a holding frame as defined herein; and a tip portion of a treatment tool channel as defined herein, and, in a cross section taken perpendicularly to the optical axis, a thickness, on a first axis that intersects the optical axis and a center of the treatment tool channel, of frame wall portions, located on two respective sides of the optical axis and intersecting the first axis, of at least a portion of the holding frame is smaller than a thickness, on a second axis that is perpendicular to the optical axis and the first axis, of frame wall portions, located on two respective sides of the optical axis and intersecting the second axis, of the at least portion of the holding frame.

Abstract: An endoscope includes in a tip portion of an insertion unit: an image sensor having plural terminals including a video terminal which outputs a video signal; and a tip potion of a treatment tool channel which extends in a longitudinal direction of the insertion unit, and a distance of the video terminal is longest among distances of the respective terminals from a center of the treatment tool channel in a plane that is perpendicular to the longitudinal axis.

Abstract: A vehicle seat achieves support rigidity of a height link mechanism coupled to a side frame that enables restraints of shaft misalignment between a drive shaft of a height brake and that of a sector gear portion. The vehicle seat includes side frames and a frame coupling member that couples the side frames together. An attachment member including a brake support portion that supports the drive shaft of the height brake is attached to the right and left insides of the right and left side frames. In the attachment member, a region located in back of the brake support portion is a region supported by the frame coupling member, and a region located in front of the brake support portion is a front frame coupling portion that is coupled to the side frames, whereby the attachment member is attached to the side frames.

Abstract: Realized is a vehicle seat capable of improving the rigidity of a cushion frame with respect to a load input to a seat back while suppressing an increase in weight and size of the cushion frame. In a vehicle seat including a height adjustment mechanism which is driven to adjust the height of a seat cushion and a brake mechanism which maintains the height of the seat cushion when the height adjustment mechanism is not driven, the brake mechanism is connected to a second connection portion different from a first connection portion connected to the seat back in the cushion frame, and reinforcement portions and which extend in a direction from the first connection portion toward the second connection portion are provided between the first connection portion and the second connection portion in the cushion frame.

Abstract: An electronic endoscope has an insert section to be introduced into a human body cavity. A distal portion of the insert section contains a CCD and a printed circuit board to which the CCD is bonded. In the insert section, a cable bundle being a bundle of coaxial cables extends. Each coaxial cable consists of a signal line, insulation surrounding the signal line, a braided wire surrounding the insulation, and an insulating jacket. The cylindrical braided wire is stranded into a single line, and is soldered as a ground line to a ground terminal of the printed circuit board. The signal line is pulled out of the coaxial cable with a length longer than the ground line. The signal line is soldered to an input/output terminal of the printed circuit board with a larger sag than the ground line.

Abstract: A solid-state image pickup device, comprising: a solid-state image pickup element; a circuit-board main body to which the solid-state image pickup element is connected; a shield piece consecutively connected to the circuit-board main body, capable of being folded, and having a shield pattern disposed; and a signal cable which is connected to a connection terminal disposed on the circuit-board main body and transmits an input/output signal to the solid-state image pickup element, wherein the shield piece is folded at least to one face side of a region where the connection terminal is formed.

Abstract: Out of optical elements that are provided to the top end side of an inserting portion of an endoscope, a first optical element arranged closest to an observation object side and a second optical element joined hermetically to the first optical element via an air layer are joined at joined surfaces by a first adhesive. Also, peripheries of end portions of the joined surfaces are covered with a second adhesive whose moisture permeability is lower than the first adhesive.