Patents by Inventor Takashi Yoshikubo

Takashi Yoshikubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Agents for Promoting the Growth of Hematopoietic Stem Cells
    Publication number: 20100040600
    Abstract: The present inventors discovered that the administration of an agonistic minibody (VB22B sc(Fv)2) against the TPO receptor resulted in not only the induction of human megakaryocyte-specific differentiation (increase in platelet precursor cells), but also the engraftment of transplanted hematopoietic stem cells derived from human cord blood (CD34-positive cells) and significant increase in multi-lineage hematopoietic precursor cells. TPO and TPO receptor agonists can be used as agents for promoting the growth of CD34-positive hematopoietic cells or agents for promoting the engraftment of transplanted cells in the bone marrow, which can be effective when administered alone (without using G-CSF and erythropoietin in combination) after hematopoietic stem cell transplantation (in particular, cord blood transplantation).
    Type: Application
    Filed: June 13, 2007
    Publication date: February 18, 2010
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Takashi Yoshikubo, Masashi Shiina, Yukiko Inagaki
  • Immunological materials and methods for detecting dihydropyrimidine dehydrogenase
    Patent number: 6730488
    Abstract: Monoclonal antibodies against dihydropyrimidine dehydrogenase are disclosed. Immunologic assays using the monoclonal antibodies are also disclosed.
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: May 4, 2004
    Assignee: Roche Diagnostics Corporation
    Inventors: Takashi Yoshikubo, Masami Hasegawa
  • Immunological materials and methods for detecting dihydropyrimidine dehydrogenase
    Publication number: 20020072080
    Abstract: Monoclonal antibodies against dihydropyrimidine dehydrogenase are disclosed. Immunologic assays using the monoclonal antibodies are also disclosed.
    Type: Application
    Filed: May 14, 2001
    Publication date: June 13, 2002
    Inventors: Takashi Yoshikubo, Masami Hasegawa
  • Immunological materials and methods for detecting dihydropyrimidine dehydrogenase
    Patent number: 6232448
    Abstract: Monoclonal antibodies against dihydropyrimidine dehydrogenase are disclosed. Immunologic assays using the monoclonal antibodies are also disclosed.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: May 15, 2001
    Assignee: Roche Diagnostics Corporation
    Inventors: Takashi Yoshikubo, Masami Hasegawa