Patents by Inventor Takateru Muraoka
Takateru Muraoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8591939Abstract: The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.Type: GrantFiled: August 4, 2005Date of Patent: November 26, 2013Assignee: Nitto Denko CorporationInventors: Yuji Saeki, Masato Nishimura, Kensuke Matsuoka, Takateru Muraoka, Yoshifumi Hosaka, Mitsuhiko Hori, Kazuhisa Ninomiya, Hitoshi Akemi, Hidetoshi Kuroda
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Patent number: 8092827Abstract: A medical non-crosslinked pressure-sensitive adhesive composition which not only has relatively high resistance to water during perspiration or the like and shows a sufficient skin adhesive force, but also can contain a large amount of a liquid plasticizer and hence have reduced skin-irritating properties. These compositions comprise an adhesive polymer A having a weight-average molecular weight of 500,000-1,000,000, an adhesive polymer B having a weight-average molecular weight of 1,000,000-1,500,000, and a liquid plasticizer, wherein the adhesive polymer A is a polymer obtained by copolymerizing one or more alkyl (meth)acrylates with N-vinyl-2-pyrrolidone and the adhesive polymer B is either a polymer obtained by the polymerization of one or more alkyl (meth)acrylates or a polymer obtained by copolymerizing one or more alkyl (meth)acrylates with one or more comonomers other than N-vinyl-2-pyrrolidone.Type: GrantFiled: April 26, 2005Date of Patent: January 10, 2012Assignee: Nitto Denko CorporationInventors: Keigo Inosaka, Takateru Muraoka
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Publication number: 20060292210Abstract: A stable percutaneous absorption-type pharmaceutical preparation for percutaneous administration of selegiline or selegiline hydrochloride, which does not suffer a decrease in the cohesive force of the adhesive layer therein even in the presence of sweat components due to perspiration during wear and which is free from cohesive failure and resultant adhesive remaining when stripped off, is provided. A percutaneous absorption-type pharmaceutical preparation which comprises: a support; and an adhesive layer containing a metal chloride, an adhesive and at least one of (?)-(R)—N,?-dimethyl-N-2-propynylphenethylamine and its hydrochloride, wherein the adhesive layer is subjected to a crosslinking treatment.Type: ApplicationFiled: June 6, 2006Publication date: December 28, 2006Inventors: Keigo Inosaka, Takateru Muraoka, Yoshihiro Iwao, Akio Takada, Toshinobu Tsuda, Junichi Sekiya
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Patent number: 7056526Abstract: The present invention provides a medical adhesive tape and a tape preparation for percutaneous absorption, both having an adhesive layer that resists glue remainder and stickiness upon peeling off of the tape even after adhesion to the human skin for a long time, and a medical adhesive composition to be used for such tapes. The medical adhesive composition of the present invention includes, as essential elements, (A) a copolymer containing (a) alkyl (meth)acrylate, wherein the alkyl moiety has 4 to 18 carbon atoms, in a proportion of not less than 50 wt % of the copolymer and (b) a carboxyl group-containing vinyl compound in a proportion of 0.1 wt %–10 wt % of the copolymer, (B) an alkoxide or a chelate compound of at least a metal selected from titanium, zirconium, zinc and aluminum, and (C) a polyol compound in a proportion of 0.2 wt %–5 wt % of the aforementioned medical adhesive composition.Type: GrantFiled: August 29, 2002Date of Patent: June 6, 2006Assignee: Nitto Denko CorporationInventors: Hidetoshi Kuroda, Takateru Muraoka, Keigo Inosaka, Hitoshi Akemi
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Publication number: 20060034900Abstract: The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.Type: ApplicationFiled: August 4, 2005Publication date: February 16, 2006Applicant: Nitto Denko CorporationInventors: Yuji Saeki, Masato Nishimura, Kensuke Matsuoka, Takateru Muraoka, Yoshifumi Hosaka, Mitsuhiko Hori, Kazuhisa Ninomiya, Hitoshi Akemi, Hidetoshi Kuroda
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Publication number: 20050238703Abstract: A medical non-crosslinked pressure-sensitive adhesive composition which not only has relatively high resistance to water during perspiration or the like and shows a sufficient skin adhesive force, but also can contain a large amount of a liquid plasticizer and hence have reduced skin-irritating properties. These compositions comprise an adhesive polymer A having a weight-average molecular weight of 500,000-1,000,000, an adhesive polymer B having a weight-average molecular weight of 1,000,000-1,500,000, and a liquid plasticizer, wherein the adhesive polymer A is a polymer obtained by copolymerizing one or more alkyl(meth)acrylates with N-vinyl-2-pyrrolidone and the adhesive polymer B is either a polymer obtained by the polymerization of one or more alkyl(meth)acrylates or a polymer obtained by copolymerizing one or more alkyl(meth)acrylates with one or more comonomers other than N-vinyl-2-pyrrolidone.Type: ApplicationFiled: April 26, 2005Publication date: October 27, 2005Inventors: Keigo Inosaka, Takateru Muraoka
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Publication number: 20030228354Abstract: The present invention provides a stable percutaneous absorption-type pharmaceutical preparation for the percutaneous absorption of basic drugs which does not cause a decrease in the cohesive force of the pressure-sensitive adhesive layer even in the presence of sweat components due to perspiration during wear; and a process for producing the pharmaceutical preparation. The percutaneous absorption-type pharmaceutical preparation comprises a substrate and, superposed on one side thereof in this order, a pressure-sensitive adhesive layer (A) comprising a pressure-sensitive adhesive and a basic drug and a pressure-sensitive adhesive layer (B) comprising a pressure-sensitive adhesive crosslinked with a crosslinking agent which is other than an organometallic compound, metal alcoholate, and metal chelate compound.Type: ApplicationFiled: June 5, 2003Publication date: December 11, 2003Applicant: NITTO DENKO CORPORATIONInventors: Takateru Muraoka, Keigo Inosaka, Hiroko Ishitani, Yoshihisa Nakano
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Publication number: 20030049440Abstract: The present invention provides a medical adhesive tape and a tape preparation for percutaneous absorption, both having an adhesive layer that resists glue remainder and stickiness upon peeling off of the tape even after adhesion to the human skin for a long time, and a medical adhesive composition to be used for such tapes. The medical adhesive composition of the present invention includes, as essential elements, (A) a copolymer containing (a) alkyl (meth)acrylate, wherein the alkyl moiety has 4 to 18 carbon atoms, in a proportion of not less than 50 wt % of the copolymer and (b) a carboxyl group-containing vinyl compound in a proportion of 0.1 wt %-10 wt % of the copolymer, (B) an alkoxide or a chelate compound of at least a metal selected from titanium, zirconium, zinc and aluminum, and (C) a polyol compound in a proportion of 0.2 wt %-5 wt % of the aforementioned medical adhesive composition.Type: ApplicationFiled: August 29, 2002Publication date: March 13, 2003Applicant: Nitto Denko CorporationInventors: Hidetoshi Kuroda, Takateru Muraoka, Keigo Inosaka, Hitoshi Akemi
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Patent number: 6231883Abstract: A medical adhesive sheet comprising a support and an adhesive layer formed on one side of said support, wherein the adhesive layer comprises an adhesive polymer having a weight average molecular weight of not less than 2,000,000, preferably not less than 2,500,000, and at least one plasticizer compatible with said polymer. The medical adhesive sheet of the present invention simultaneously satisfies the adhesive property to the skin and low irritation property, since it can retain the plasticizer in the adhesive layer, even without a crosslinking treatment. The effects of the present invention can be exerted irrespective of the kind of functional group that the plasticizer and drug have.Type: GrantFiled: July 17, 1998Date of Patent: May 15, 2001Assignee: Nitto Denko CorporationInventors: Keigo Inosaka, Takateru Muraoka, Hitoshi Akemi, Saburo Otsuka, Yuichi Inoue
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Patent number: 6139867Abstract: A medical adhesive sheet comprising a support having a laminate structure comprising a non-porous sheet and a porous-sheet, and a pressure-sensitive layer comprising an acrylic polymer prepared by polymerizing an alkyl (meth)acrylate as a main component monomer, and an organic liquid component which is compatible with the acrylic polymer, formed on the porous sheet side of the support, the layer being subjected to a crosslinking treatment, wherein the pressure-sensitive adhesive layer is embedded in the porous sheet, reaching the laminate interface between the non-porous sheet and the porous sheet. The medical adhesive sheet has improved anchoring property of its pressure-sensitive adhesive layer to the support while exhibiting a good balance between adhesion to the skin and low irritation to the skin.Type: GrantFiled: August 26, 1994Date of Patent: October 31, 2000Assignee: Nitto Denko CorporationInventors: Takateru Muraoka, Takashi Kinoshita, Hitoshi Akemi, Saburo Otsuka
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Patent number: 6132761Abstract: The present invention provides a percutaneous absorption preparation which hardly causes the coloration phenomenon and is excellent in the stability of the drug content. The percutaneous absorption preparation comprises a support and a pressure-sensitive adhesive layer formed on at least one side of the support, wherein the pressure-sensitive adhesive layer contains a percutaneous absorptive drug and at least one of 2-mercaptobenzimidazole and propyl gallate, with the proviso that the percutaneous absorptive drug is not 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole and pharmacologically acceptable salt thereof.Type: GrantFiled: September 3, 1998Date of Patent: October 17, 2000Assignee: Nitto Denko CorporationInventors: Takateru Muraoka, Hitoshi Akemi, Keigo Inosaka, Hiroko Ishitani, Saburo Otsuka
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Patent number: 6077528Abstract: The present invention relates to a percutaneous preparation comprising an adhesive layer formed on at least one side of a substrate, the layer containing an acrylic copolymer, 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole or an acid addition salt thereof, and 2-mercaptobenzimidazole. This preparation exhibits superior percutaneous absorption of the benzimidazole compound and long sustention of efficacy, and shows an improved stability of the active ingredient, benzimidazole compound, in the preparation.Type: GrantFiled: November 24, 1998Date of Patent: June 20, 2000Assignees: Nitto Denko Corporation, Kanebo, Ltd.Inventors: Takateru Muraoka, Keigo Inosaka, Hitoshi Akemi, Hiroko Ishitani, Saburo Otsuka, Yoshiteru Takahashi
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Patent number: 5876745Abstract: A medical adhesive sheet comprising a support having a laminate structure comprising a non-porous sheet and a porous sheet, and a pressure-sensitive layer comprising an acrylic polymer prepared by polymerizing an alkyl (meth)acrylate as a main component monomer, and an organic liquid component which is compatible with the acrylic polymer, formed on the porous sheet side of the support, the layer being subjected to a crosslinking treatment, wherein the pressure-sensitive adhesive layer is embedded in the porous sheet, reaching the laminate interface between the non-porous sheet and the porous sheet. The medical adhesive sheet has improved anchoring property of its pressure-sensitive adhesive layer to the support while exhibiting a good balance between adhesion to the skin and low irritation to the skin.Type: GrantFiled: January 23, 1997Date of Patent: March 2, 1999Assignee: Nitto Denko CorporationInventors: Takateru Muraoka, Takashi Kinoshita, Hitoshi Akemi, Saburo Otsuka
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Patent number: 5683710Abstract: A percutaneous absorption preparation for use in the administration of isosorbide dinitrate (ISDN) as a coronary vasodilator into the living body by percutaneous absorption, which has excellent adhesion to the skin and does not cause pain and damage to stratum corneum when peeled off, is disclosed. The pressure-sensitive adhesive layer comprises an acrylic copolymer prepared by copolymerization of a monomer mixture comprising a (meth)acrylic acid alkyl ester and a functional monomer as the essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms, and ISDN, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of ISDN is improved and the area of the preparation can be decreased.Type: GrantFiled: September 13, 1995Date of Patent: November 4, 1997Assignees: Nitto Denko Corporation, Toa Eiyo Ltd.Inventors: Hitoshi Akemi, Takateru Muraoka, Kazuhiro Higashio, Saburo Otsuka, Takashi Kinoshita
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Patent number: 5650165Abstract: This invention provides a percutaneous absorption preparation for use in the percutaneous administration of drugs for percutaneous absorption into the living body for the purpose of preventing or treating various diseases, which has excellent adhesion to the skin and does not cause pain and damage to corneum when peeled off. Its pressure-sensitive adhesive layer contains an acrylic copolymer comprising a (meth)acrylic acid alkyl ester and a functional monomer as essential components, a fatty acid ester having a specified number of carbon atoms, a monoglyceride having a specified number of carbon atoms and a drug for percutaneous absorption, and the pressure-sensitive adhesive layer is crosslinked. Since its skin adhesive property is improved by the inclusion of the monoglyceride, release of the drug from the preparation is improved and the area of the preparation can be miniaturized.Type: GrantFiled: November 7, 1995Date of Patent: July 22, 1997Assignee: Nitto Denko CorporationInventors: Hitoshi Akemi, Takateru Muraoka, Kazuhiro Higashio, Yutaka Suzuki, Saburo Otsuka
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Patent number: 5505306Abstract: A package structure, in which a drug-containing pressure-sensitive adhesive sheet comprising a support, a drug-containing pressure-sensitive adhesive layer, and a separator in this order is packaged and sealed in a packaging material, is disclosed, wherein unevenness is provided on at least one of the surface of the support on the side in contact with the inside of the packaging material, the surface of the separator on the side in contact with the inside of the packaging material, and the inside surface of the packaging material. The unevenness reduces the contact area between the packaging material and the sheet so that an adhesive, a plasticizer or any liquid component of the adhesive layer is prevented from adhering to the inside of the packaging material. Therefore, the sheet can easily be taken out of unit package on use.Type: GrantFiled: July 14, 1994Date of Patent: April 9, 1996Assignee: Nitto Denko CorporationInventors: Hitoshi Akemi, Takashi Kinoshita, Takateru Muraoka, Kazuhiro Higashio, Saburo Otsuka