Abstract: The present disclosure provides a method for producing a microchannel device, which can form a channel that has high hydrophobicity, high solvent resistance as well, and also resistance to heat and damage, on demand with high accuracy, and produces the microchannel device at a low cost, while having high productivity. The method for producing a microchannel device includes: forming a channel pattern from a hydrophobic resin on a porous substrate by an electrophotographic method; melting the channel pattern by heat to allow the channel pattern to permeate into the porous substrate, thereby forming a channel in the inside of the porous substrate.

Abstract: The present invention provides a pharmaceutical composition for cancer treatment comprising an antibody against CCR8.

Abstract: An image forming apparatus includes a rotatable image bearing member, a developing member, a transfer member, and a brush contacting a surface of the image bearing member in a contact portion downstream of a transfer portion and upstream of a developing portion with respect to a rotational direction of the image bearing member. The toner which is not transferred onto a toner image receiving member is collected by the developing member. In a charging series, the toner is positioned on the same side as a normal charge polarity of the toner relative to the brush. In the contact portion, a maximum value of a contact pressure of 0.7 gf/mm2 or more and 3.5 gf/mm2 or less, a maximum contact area ratio is 18% or more and 74% or less, and a Clark-Evans index of the brush is 1 or more.

Abstract: An image forming apparatus includes a rotatable image bearing member, a developing member, a transfer member, and a brush contacting a surface of the image bearing member in a contact portion downstream of a transfer portion and upstream of a developing portion with respect to a rotational direction of the image bearing member. The toner which is not transferred onto a toner image receiving member is collected by the developing member. In a charging series, the toner is positioned on the same side as a normal charge polarity of the toner relative to the brush. In the contact portion, a maximum value of a contact pressure of 0.7 gf/mm2 or more and 3.5 gf/mm2 or less, a maximum contact area ratio is 18% or more and 74% or less, and a Clark-Evans index of the brush is 1 or more.

Abstract: An image forming apparatus includes a rotatable image bearing member, a developing member, a transfer member, and a brush contacting a surface of the image bearing member in a contact portion downstream of a transfer portion and upstream of a developing portion with respect to a rotational direction of the image bearing member. The toner which is not transferred onto a toner image receiving member is collected by the developing member. In a charging series, the toner is positioned on the same side as a normal charge polarity of the toner relative to the brush. In the contact portion, a maximum value of a contact pressure of 0.7 gf/mm2 or more and 3.5 gf/mm2 or less, a maximum contact area ratio is 18% or more and 74% or less, and a Clark-Evans index of the brush is 1 or more.

Abstract: An image forming apparatus includes a rotatable image bearing member, a charging member, a developing member, a transfer member, an exposure unit, and a controller. The controller executes a preparatory operation in which before an image forming operation, rotation of the image bearing member is started and a charging voltage and a developing voltage are increased stepwise. In the preparatory operation, the controller carries out control so as to start application of the charging voltage at a voltage value not less than a discharge start voltage of the charging member before a surface region of the image bearing member positioned in a developing portion at a time of a start of the rotation of the image bearing member reaches a charging portion in a state which a surface of the image bearing member is exposed to light by the exposure unit.

Abstract: The present disclosure provides a method for producing a microchannel device, which can form a channel that has high hydrophobicity, high solvent resistance as well, and also resistance to heat and damage, on demand with high accuracy, and produces the microchannel device at a low cost, while having high productivity. The method for producing a microchannel device includes: forming a channel pattern from a hydrophobic resin on a porous substrate by an electrophotographic method; melting the channel pattern by heat to allow the channel pattern to permeate into the porous substrate, thereby forming a channel in the inside of the porous substrate.

Abstract: Provided is a microchannel device, which has high hydrophobicity, high mechanical strength, and safety and also has high solvent resistance, and thus has wider applicability. The microchannel device includes a porous substrate having formed therein channel walls each containing a cyclic olefin copolymer that is a copolymer of an alkene and a cyclic olefin.

Abstract: The present invention provides a pharmaceutical composition for cancer treatment comprising an antibody against CCR8.

Abstract: The present invention provides a pharmaceutical composition for cancer treatment comprising an antibody against CCR8.

Abstract: In an image forming apparatus of a direct transfer system, when in a region where a transfer nip portion of a photosensitive drum is formed, a region in which the toner image can be formed is defined as a first region, and a region where the recording medium does not pass while the recording medium is conveyed by the transfer nip portion is defined as a second region, in forming the toner image on the recording medium, the photosensitive drum enters the transfer nip portion in a state where the second region of the photosensitive drum includes a region in which an absolute value of a surface potential is smaller than an absolute value of a surface potential of a region in which the toner image is not formed in the first region.

Abstract: A cleaning device, including: a cleaning frame; a cleaning member having one end and the other end, an image bearing member being capable of rotating and bearing a developer image formed of a developer so as to remove the developer remaining on the image bearing member after transfer of the developer image from the image bearing member; and a sheet member having flexibility and having one end and the other end; wherein a work function W (D) of the developer and a work function W (S) of the sheet member satisfy 0?W(D)?W(S)?0.23 and the developer includes inorganic particles, and at least one kind of the inorganic particles has an average primary particle diameter of 50 nm or larger.

Abstract: A cleaning device has: a cleaning frame; a cleaning member which, after transfer through contact with an image bearing member, removes a developer remaining on the image bearing member; and a sheet member having flexibility and coming into contact with the image bearing member at an upstream side of a contact position between the cleaning member and the image bearing member in the rotation direction of the image bearing member. An external additive is an inorganic salt having a charging polarity on the positive side with respect to the developer, and work functions ?(S), ?(A), ?(T) of the sheet member, the external additive and the developer satisfy 0?|?(A)??(S)|<0.57; and ?(A)<?(T).

Abstract: The disclosure provides a method of measuring an efficacy of a drug composition for cancer and a method for treating a cancer by administering to a subject an effective amount of a pharmaceutical composition having a polypeptide that binds to a peptide produced by cDNA of GenBank ACC No. NM_005201.3 or NM_007720.2.

Abstract: The disclosure provides a pharmaceutical composition with a polypeptide that binds to a peptide produced by cDNA of GenBank ACC No. NM_005201.3 or NM_007720.2, and methods of use thereof.

Abstract: A cleaning device has: a cleaning frame; a cleaning member which, after transfer through contact with an image bearing member, removes a developer remaining on the image bearing member; and a sheet member having flexibility and coming into contact with the image bearing member at an upstream side of a contact position between the cleaning member and the image bearing member in the rotation direction of the image bearing member. The external additive is an inorganic salt having a charging polarity on the positive side with respect to the developer, and work functions ?(S), ?(A), ?(T) of the recovery member, the external additive and the developer satisfy 0?|?(A)??(S)|<0.57; and ?(A)<?(T).

Abstract: A cleaning device, including: a cleaning frame; a cleaning member having one end and the other end, the image bearing member being capable of rotating and bearing a developer image formed of a developer so as to remove the developer remaining on the image bearing member after transfer of the developer image from the image bearing member; and a sheet member having flexibility and having one end and the other end; wherein a work function W (D) of the developer and a work function W (S) of the sheet member satisfy 0?W(D)?W(S)?0.23 and the developer includes inorganic particles, and at least one kind of the inorganic particles has an average primary particle diameter of 50 nm or larger.

Abstract: The present invention provides a pharmaceutical composition for cancer treatment comprising an antibody against CCR8.

Abstract: In an image forming apparatus of a direct transfer system, when in a region where a transfer nip portion of a photosensitive drum is formed, a region in which the toner image can be formed is defined as a first region, and a region where the recording medium does not pass while the recording medium is conveyed by the transfer nip portion is defined as a second region, in forming the toner image on the recording medium, the photosensitive drum enters the transfer nip portion in a state where the second region of the photosensitive drum includes a region in which an absolute value of a surface potential is smaller than an absolute value of a surface potential of a region in which the toner image is not formed in the first region.

Abstract: An image forming apparatus includes an image bearing member, a charging member, a charging voltage source, an electrostatic image forming portion, a developing member, a developing voltage source, a transfer portion, a cleaning member, and a controller. The controller effects control so that a peak-to-peak voltage of an AC component of a charging voltage satisfying the following relationship is applied to the charging member to execute a toner supplying operation: 2Vth (V)?Vpp1 (V)?(2Vth+200) (V), where a discharge start voltage of a DC component of a charging voltage between the image bearing member and the charging member is Vth (V), and the peak-to-peak voltage of the AC component applied during execution of the toner supplying operation is Vpp1 (V). A peak-to-peak voltage of the AC component applied during image formation is larger than the peak-to-peak voltage Vpp1 (V).