Abstract: The disclosure includes a method of preparing a cancer spheroid, a method of selecting a colorectal cancer patient being sensitive to an FGFR inhibitor, and a pharmaceutical composition for treating colorectal cancer comprising an FGFR inhibitor.

Abstract: The present invention provides a signal block sequence processing method. According to the method, signal block headers (Bch, Bdh) are deleted from each sequence of signal blocks (B) each composed of the signal block header indicating whether a signal block payload is a control block payload (Bc?) containing a control code is contained or a data block payload (Bd?) containing data is contained. The resultant signal blocks are formed into one group (G). Each control block payload in the group is provided with position determination information indicating the position of the control block payload in the group. The signal block payloads are rearranged in accordance with a signal block payload rearrangement rule. The rearranged signal block payloads are contained in a super-block payload (Sc), to which a super-block header (Shc) indicative of containment of control block payloads is added. The resultant super-block (S) is output.

Abstract: A vehicle, such as a motorcycle, can include an engine, an exhaust pipe, and a silencer. The silencer can include a main body and first and second pipes. An upstream end of the first pipe can be connected to the exhaust pipe, and be provided in the main body. The second pipe can be provided apart from the first pipe on the downstream side of the first pipe, coaxially with the first pipe, and extending through a downstream lid of an outer tube of the main body. The downstream portion of the first pipe can have an inner diameter that gradually decreases from the upstream side toward the downstream end. The upstream end of the second pipe can be provided in the main body and have a larger inner diameter than the inner diameter of the downstream end of the first pipe.

Abstract: A normal person (i.e. a control) and liver diseases such as drug induced liver injury, an asymptomatic hepatitis B carrier, an asymptomatic hepatitis C carrier, chronic hepatitis B, chronic hepatitis C, liver cancer, a nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and simple steatosis (SS) are identified by measuring the concentrations of ?-Glu-X (X represents an amino acid or an amine) peptides or the levels of AST or ALT in blood and carrying out, for example, a multiple logistic regression based on the measured value.

Abstract: A vehicle, such as a motorcycle, can include an engine, an exhaust pipe, and a silencer. The silencer can include a main body and first and second pipes. An upstream end of the first pipe can be connected to the exhaust pipe, and be provided in the main body. The second pipe can be provided apart from the first pipe on the downstream side of the first pipe, coaxially with the first pipe, and extending through a downstream lid of an outer tube of the main body. The downstream portion of the first pipe can have an inner diameter that gradually decreases from the upstream side toward the downstream end. The upstream end of the second pipe can be provided in the main body and have a larger inner diameter than the inner diameter of the downstream end of the first pipe.