Patents by Inventor Takenori Ishizawa
Takenori Ishizawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220017456Abstract: It was discovered that a cyclic sulfamidate can be produced by reacting an amino acid derivative with a cyclization reagent. In addition, it was discovered that an O-substituted serine derivative can be produced by reacting a cyclic sulfamidate with an alcohol.Type: ApplicationFiled: November 7, 2019Publication date: January 20, 2022Inventor: Takenori ISHIZAWA
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Patent number: 8088916Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.Type: GrantFiled: March 4, 2005Date of Patent: January 3, 2012Assignee: Denki Kagaku Kogyo Kabushiki KaishaInventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi
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Patent number: 7807675Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.Type: GrantFiled: April 1, 2005Date of Patent: October 5, 2010Assignee: Denki Kagaku Kogyo Kabushiki KaishaInventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Noriyuki Izutani, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi, Tatsuya Kato, Akie Honma
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Patent number: 7612070Abstract: There is provided a compound represented by the general formula (1): wherein Het represents an optional substituted heterocylic group A1 and A2 each independently represent —CH?, etc.; A3 represents —CH2—, etc.; R1 represents a 4-fluorophenyl group, etc.; R2 represents an alkyl group; n represents 0, 1 or 2, provided that when A1 and A2 both are —CH?, A3 represents —CH2— or —SO2—, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof.Type: GrantFiled: February 16, 2005Date of Patent: November 3, 2009Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroharu Matsuoka, Nobuaki Kato, Tadakatsu Takahashi, Noriaki Maruyama, Takenori Ishizawa, Yukio Suzuki
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Publication number: 20090093414Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.Type: ApplicationFiled: April 1, 2005Publication date: April 9, 2009Applicant: Denki Kagaku Kogyo Kabushiki KaishaInventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Noriyuki Izutani, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi, Tatsuya Kato, Akie Honma
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Publication number: 20070197465Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.Type: ApplicationFiled: March 4, 2005Publication date: August 23, 2007Applicants: Denki Kagaku Kabushiki Kaisha, Chugai Seiyaku Kabushiki KaishaInventors: Hitoshi Ikeya, Tadashi Morikawa, Koichi Takahashi, Tatsuya Tamura, Akira Okamachi, Takenori Ishizawa, Haruhiko Sato, Yoshinobu Higuchi
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Publication number: 20050137202Abstract: There is provided a compound represented by the general formula (1): wherein Het represents an optional substituted heterocylic group A1 and A2 each independently represent —CH?, etc.; A3 represents —CH2—, etc.; R1 represents a 4-fluorophenyl group, etc.; R2 represents an alkyl group; n represents 0, 1 or 2, provided that when A1 and A2 both are —CH?, A3 represents —CH2— or —SO2—, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof.Type: ApplicationFiled: February 16, 2005Publication date: June 23, 2005Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Hiroharu Matsuoka, Nobuaki Kato, Tadakatsu Takahashi, Noriaki Maruyama, Takenori Ishizawa, Yukio Suzuki
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Patent number: 6875770Abstract: There is provided a compound represented by the general formula (1): wherein Het represents an optional substituted heterocylic group A1 and A2 each independently represent —CH?, etc.; A3 represents —CH2—, etc.; R1 represents a 4-fluorophenyl group, etc.; R2 represents an alkyl group; n represents 0, 1 or 2, provided that when A1 and A2 both are —CH?, A3 represents —CH2— or —SO2—, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof.Type: GrantFiled: October 1, 2003Date of Patent: April 5, 2005Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroharu Matsuoka, Nobuaki Kato, Tadakatsu Takahashi, Noriaki Maruyama, Takenori Ishizawa, Yukio Suzuki
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Publication number: 20040067964Abstract: There is provided a compound represented by the general formula (1): 1Type: ApplicationFiled: October 1, 2003Publication date: April 8, 2004Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Hiroharu Matsuoka, Nobuaki Kato, Tadakatsu Takahashi, Noriaki Maruyama, Takenori Ishizawa, Yukio Suzuki
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Patent number: 6673797Abstract: There is provided a compound represented by the general formula (1): wherein Het represents an optionally substituted heterocyclic group; A1 and A2 each independently represent —CH═, etc.; A3 represents —CH2—, etc.; R1 represents a 4-fluorophenyl group, etc.; R2 represents an alkyl group; n represents 0, 1 or 2, provided that when A1 and A2 both are —CH═, A3 represents —CH2— or —SO2—, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof.Type: GrantFiled: November 27, 2000Date of Patent: January 6, 2004Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroharu Matsuoka, Nobuaki Kato, Tadakatsu Takahashi, Noriaki Maruyama, Takenori Ishizawa, Yukio Suzuki
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Publication number: 20030065189Abstract: Starting, for example, from 1-fluoro-2-fluoromethyl-3-butyn-2-yl 4-trifluoromethylphenyl ether, N-(2-cyanoethyl)-5-fluoro-4-fluoromethyl-4-(4-trifluoromethylphenoxy)-2-pentynamide is produced and then cyclized to synthesize 2,2-bis(fluoromethyl)-N-(2-cyanoethyl)-6-trifluoromethyl-2H-1-benzopyran-4-carboxamide. The invention processes for producing 4-substituted benzopyran derivatives involve fewer steps, feature greater safety and allow for easier purification than the prior art processes.Type: ApplicationFiled: August 6, 2002Publication date: April 3, 2003Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Yukio Suzuki, Takenori Ishizawa, Vladimir A. Khlebnikov, Masashi Watanabe
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Patent number: 6455708Abstract: Starting, for example, from 1-fluoro-2-fluoromethyl-3-butyn-2-yl 4-trifluoromethylphenyl; ether, N-(2-cyanoethyl)-5-fluoro-4-fluoromethyl-4-(4-trifluoromethylphenoxy)-2-pentynamide is produced and then cyclized to synthesize 2,2-bis(fluoromethyl)-N-(2-cyanoethyl)-6-trifluoromethyl-2H-1-benzopyran-4-carboxamide. The invention processes for producing 4-substituted benzopyran derivatives involve fewer steps, feature greater safety and allow for easier purification than the prior art processes.Type: GrantFiled: March 21, 2001Date of Patent: September 24, 2002Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Yukio Suzuki, Takenori Ishizawa, Vladimir A. Khlebnikov, Masashi Watanabe
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Patent number: 5977167Abstract: Novel benzopyran and benzoxazine derivatives represented by the general formula: wherein R.sub.1 and R.sub.2 represent a lower haloalkyl group, R.sub.3 represents a hydrogen atom, etc., R.sub.4 represents a heterocyclic group or A--O-- wherein A represents a cyclic structure, etc., R.sub.5 and R.sub.6 represent a lower haloalkyl, X represents .dbd.N--, N.fwdarw.O, etc, are disclosed. These compounds exhibit K.sup.+ channel opening activating and can be widely used as an anti-asthma drug, an anti-epilepsy drug, etc.Type: GrantFiled: February 19, 1998Date of Patent: November 2, 1999Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroshi Koga, Haruhiko Sato, Takenori Ishizawa, Hiroyuki Nabata
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Patent number: 5874446Abstract: Novel benzopyran and benzoxazine derivatives represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2 represent a lower haloalkyl group, R.sub.3 represents a hydrogen atom, etc., R.sub.4 represents a heterocyclic group or A--O-- wherein A represents a cyclic structure, etc., R.sub.5 and R.sub.6 represent a lower haloalkyl, X represents .dbd.N--, N.fwdarw.O, etc, are disclosed. These compounds exhibit K.sup.+ channel opening activating and can be widely used as an anti-asthma drug, an anti-epilepsy drug, etc.Type: GrantFiled: June 27, 1996Date of Patent: February 23, 1999Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroshi Koga, Haruhiko Sato, Takenori Ishizawa, Hiroyuki Nabata
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Patent number: 5646310Abstract: Described herein are benzopyran derivatives represented by the formula: ##STR1## wherein R, X and Y represent any of the following combinations:______________________________________ R X Y ______________________________________ C.sub.2 F.sub.5 O H C.sub.2 F.sub.5 S H CF.sub.3 S F C.sub.2 F.sub.5 S F C.sub.3 F.sub.7 S F ______________________________________and pharmaceutically acceptable salts thereof. These compounds have an excellent potassium channel activity and are also excellent from the aspect of safety.Type: GrantFiled: June 7, 1995Date of Patent: July 8, 1997Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroshi Koga, Haruhiko Sato, Takenori Ishizawa
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Patent number: 5614633Abstract: Novel benzopyran and benzoxazine derivatives represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2 represent a lower haloalkyl group, R.sub.3 represents a hydrogen atom, etc., R.sub.4 represents a heterocyclic group or A--O-- wherein A represents a cyclic structure, etc., R.sub.5 and R.sub.6 represent a lower haloalkyl, X represents .dbd.N--, N.fwdarw.O, etc, are disclosed. These compounds exhibit K.sup.+ channel opening activating and can be widely used as an anti-asthma drug, an anti-epilepsy drug, etc.Type: GrantFiled: February 17, 1995Date of Patent: March 25, 1997Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Hiroshi Koga, Haruhiko Sato, Takenori Ishizawa, Hiroyuki Nabata