Abstract: A coffee machine provided with a second grinder for grinding coffee beans, and provides a coffee machine that is controlled in consideration of a state for grinding coffee beans in the grinder. A coffee machine including a second grinder for grinding coffee beans, in which an input amount of coffee beans to be put into the second grinder is controlled.

Abstract: A coffee machine provided with a second grinder for grinding coffee beans, and provides a coffee machine that is controlled in consideration of a state for grinding coffee beans in the grinder. A coffee machine including a second grinder for grinding coffee beans, in which an input amount of coffee beans to be put into the second grinder is controlled.

Abstract: A grafting technique effective for crops such as soybean and plants of the Poaceae family including rice, wheat, corn, etc. and a method of grafting crops of the present invention comprising the steps of replacing a radicle of a dry dormant seed with a radicle of another dormant seed capable of achieving grafting, and thereafter, germinating the seed.

Abstract: The present invention provides a dihydropyridazine-3,5-dione derivative or a salt thereof, or a solvate of the compound or the salt, a pharmaceutical drug, a pharmaceutical composition, a sodium-dependent phosphate transporter inhibitor, and a preventive and/or therapeutic agent for hyperphosphatemia, secondary hyperparathyroidism, chronic renal failure, chronic kidney disease, and arteriosclerosis associated with vascular calcification comprising the compound as an active ingredient, and a method for prevention and/or treatment.

Abstract: The present invention provides a dihydropyridazine-3,5-dione derivative or a salt thereof, or a solvate of the compound or the salt, a pharmaceutical drug, a pharmaceutical composition, a sodium-dependent phosphate transporter inhibitor, and a preventive and/or therapeutic agent for hyperphosphatemia, secondary hyperparathyroidism, chronic renal failure, chronic kidney disease, and arteriosclerosis associated with vascular calcification comprising the compound as an active ingredient, and a method for prevention and/or treatment.

Abstract: An object of the present invention is to provide a grafting technique effective also for crops such as soybean and plants of the Poaceae family including rice, wheat, corn, etc. A method of cultivating a crop of the present invention as a solution means thereof is characterized by comprising replacing a radicle of a dry seed with a radicle of another seed capable of achieving grafting, and thereafter, germinating the seed.

Abstract: An object of the present invention is to provide a method for transforming a plant by grafting of a rootstock and a scion, and using siRNA for initiating transcriptional gene silencing. The method for transforming a plant by grafting of a rootstock and a scion of the present invention as a means for resolution is characterized in that siRNA for initiating transcriptional gene silencing is produced in a scion, the siRNA produced in the scion is transported to a rootstock by grafting, and the rootstock is transformed by initiating transcriptional gene silencing therein.

Abstract: Methods of using a compound, its pharmaceutically acceptable salts, and/or its pro-drug esters, in isolated form, to treat cancer, and methods for isolating, for formulating, and for administering the compound, salt, and/or pro-drug ester as an antitumor agent, wherein the compound, salt, or pro-drug ester has the following generic structure: wherein R1, R2, R3, R4, R5, R6, R7, R8, X1 and X2 are selected from specified residues, as described, and the dashed bond represents either a carbon-carbon single bond or a carbon-carbon double bond.

Abstract: Methods of using a compound, its pharmaceutically acceptable salts, and/or its pro-drug esters, in isolated form, to treat cancer, and methods for isolating, for formulating, and for administering the compound, salt, and/or pro-drug ester as an antitumor agent, wherein the compound, salt, or pro-drug ester has the following structure: 1

Abstract: A compound, its pharmaceutically acceptable salts, and/or its pro-drug esters, in isolated form, and methods for isolating, for formulating, and for administering the compound, salt, and/or pro-drug ester as an antitumor agent, wherein the compound, salt, or pro-drug ester has the following structure: wherein: R1, R2, R5, R7,and R8 are each separately selected from the group consisting of a hydrogen atom, a halogen atom, and saturated C1-C24 alkyl, unsaturated C1-C24 alkenyl, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, nitro, substituted nitro, phenyl, and substituted phenyl groups, R3, R4, and R6 are each separately selected from the group consisting of a hydrogen atom, a halogen atom, and saturated C1-C12 alkyl, unsaturated C1-C12 alkenyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, nitro, and substituted nitro groups, X1 and

Abstract: Compounds of the following general formula (I) and pharmaceutically acceptable salts thereof.

Abstract: Herein disclosed is a method and an apparatus for judging the fitness of a steel composition for a particular casting practice in order to prevent excessive segregation of manganese and phosphorous in the course of the casting. We have discovered that the simultaneous segregation of manganese and phosphorous tends to cause the formation of bainite and/or martensite in steel plate product during the cooling of the steel plate after rolling. When the manganese and phosphorous concentrations satisfy the following requirement (1):Mn (%) .times. P (%) <0.60/f . . . . (1)wherein f denotes the segregation factor of the particular casting practice, regarding the product of Mn (%) and P (%), the formation of bainite and/or martensite is prevented. Accordingly, it is possible to predict the fitness of the molten steel to the particular casting practice.