Abstract: An object of the present invention is to obtain a capsule for treating ulcerative colitis which, when a capsule containing indigo is orally administered, acts more effectively than conventional ones and has less side effects of hepatotoxicity by not easily disintegrating in the stomach and small intestine but only in the large intestine. The present invention relates to a capsule for treating ulcerative colitis which disintegrates locally in the large intestine, comprising a drug-containing content, a protective layer coating the content and a film formed outside the protective layer, which are arranged concentrically, wherein the content is a content in which indigo, which is a drug for treating ulcerative colitis, is dispersed or dissolved, and the film is locally disintegrated in the large intestine.

Abstract: An object of the present invention is to obtain a capsule for treating ulcerative colitis which, when a capsule containing indigo is orally administered, acts more effectively than conventional ones and has less side effects of hepatotoxicity by not easily disintegrating in the stomach and small intestine but only in the large intestine. The present invention relates to a capsule for treating ulcerative colitis which disintegrates locally in the large intestine, comprising a drug-containing content, a protective layer coating the content and a film formed outside the protective layer, which are arranged concentrically, wherein the content is a content in which indigo, which is a drug for treating ulcerative colitis, is dispersed or dissolved, and the film is locally disintegrated in the large intestine.

Abstract: The present invention provides an orally administered agent for ruminants which reaches lower digestive tract without decomposition in the rumen by avoiding the destruction thereof due to rumination, and is disintegrated and dissolved in vivo. The present invention provides an orally administered agent for ruminants, of which the specific gravity is 1.17 to 2.00, the maximum particle size and minimum particle size are either within the range of 4 to 10 mm, and the breaking strength of a portion having the minimum particle size under body temperature environment of the ruminants is within the range of 0.5 to 5.0 N. The present invention further provides ruminant feed containing the orally administered agent and a method of orally administering a drug to ruminants.