Patents by Inventor Takuya Yokosawa
Takuya Yokosawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230406962Abstract: There are provided hydroxypropyl methyl cellulose (HPMC) having high solubility even when keeping the molar substitution (MS) of hydroxypropoxy groups conventional; and others. More specifically, there are provided HPMC having a molar substitution (MS) of hydroxypropoxy groups of from 0.1 to 0.5, a ratio (referred to as “MF at 3-position/MS”) of 0.12 or more, as calculated by dividing a molar fraction (referred to as “MF at 3-position”) of anhydroglucose units in which only a hydroxy group at the 3-position carbon is substituted with a hydroxypropoxy group and none of hydroxy groups at the 2-position and 6-position carbons is substituted with a hydroxypropoxy group by the molar substitution (referred to as “MS”) of hydroxypropoxy groups, and a viscosity at 20° C. of more than 50 mPa·s and not more than 150000 mPa·s, as determined in a 2% by mass aqueous solution; and others.Type: ApplicationFiled: June 14, 2023Publication date: December 21, 2023Inventors: Kentaro Miki, Takuya Yokosawa
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Publication number: 20230407057Abstract: There are provided hydroxypropyl methyl cellulose (HPMC) having a high solubility in an organic solvent even when it has a degree of substitution (DS) of methoxy groups and a molar substitution (MS) of hydroxypropoxy group which are the same as those in the conventional art; and others. Specifically, there are provided HPMC having the MS of from 0.1 to 0.5; a ratio (referred to as “MF at 3-position/MS”) of 0.12 or more, as calculated by dividing a molar fraction (referred to as “MF at 3-position”) of anhydroglucose units in which only a hydroxy group at the 3-position carbon is substituted with a hydroxypropoxy group and none of hydroxy groups at the 2-position and 6-position carbons is substituted with a hydroxypropoxy group by the MS; and a viscosity at 20° C. of from 1.0 to 50 mPa·s, as determined in a 2% by mass aqueous solution; and others.Type: ApplicationFiled: June 14, 2023Publication date: December 21, 2023Inventors: Takuya Yokosawa, Kentaro Miki
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Publication number: 20230301920Abstract: Provided are a hydroxyalkylalkyl cellulose excellent in formability and not causing marked delay in disintegration when added even in a small amount; a solid preparation including the hydroxyalkylalkyl cellulose; and a method for producing the solid preparation. More specifically, provided are a hydroxyalkylalkyl cellulose for tableting having a specific surface area of from 0.5 to 5.0 m2/g as measured by BET and a solid preparation including the hydroxyalkylalkyl cellulose.Type: ApplicationFiled: May 19, 2023Publication date: September 28, 2023Inventors: Takuya YOKOSAWA, Naosuke MARUYAMA
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Patent number: 11479658Abstract: There is provided a film-forming composition, including: a first water-soluble cellulose ether (WSCE) having a viscosity at 20° C. of 2.5 to 45 mPa·s, a second WSCE having a viscosity at 20° C. of 6.0 to 50.0 mPa·s, a third WSCE having a viscosity at 20° C. of 4.5 to 15.0 mPa·s, each viscosity being determined in a 2% by mass aqueous solution, and a solvent, wherein the first WSCE is selected from four members of hydroxypropyl methyl celluloses Ia and Ib in Group I and hydroxypropyl methyl cellulose IIa and methyl cellulose IIb in Group II, the second WSCE is the same member as that of the first WSCE, provided that the substitution degree(s) of the second WSCE may be the same as or different from that of the first WSCE, and the third WSCE is selected from members in a Group different from the Group of the first WSCE.Type: GrantFiled: March 9, 2021Date of Patent: October 25, 2022Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Shintaro Matsusue, Takuya Yokosawa
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Publication number: 20210284823Abstract: There is provided a film-forming composition, including: a first water-soluble cellulose ether (WSCE) having a viscosity at 20° C. of 2.5 to 45 mPa·s, a second WSCE having a viscosity at 20° C. of 6.0 to 50.0 mPa·s, a third WSCE having a viscosity at 20° C. of 4.5 to 15.0 mPa·s, each viscosity being determined in a 2% by mass aqueous solution, and a solvent, wherein the first WSCE is selected from four members of hydroxypropyl methyl celluloses Ia and Ib in Group I and hydroxypropyl methyl cellulose IIa and methyl cellulose IIb in Group II, the second WSCE is the same member as that of the first WSCE, provided that the substitution degree(s) of the second WSCE may be the same as or different from that of the first WSCE, and the third WSCE is selected from members in a Group different from the Group of the first WSCE.Type: ApplicationFiled: March 9, 2021Publication date: September 16, 2021Inventors: Shintaro Matsusue, Takuya Yokosawa
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Patent number: 11052051Abstract: Provided are a drug-containing particle capable of suppressing dissolution of a drug in the oral cavity to suppress an unpleasant taste thereof and having excellent dissolution of the drug in the digestive tract after passing through the oral cavity; a method for preparing the drug-containing particle; a coating composition used for preparing the drug-containing particle; and a solid preparation having the drug-containing particle. More specifically, provided are a coating composition having 100 parts by weight of a cellulose-based enteric base and 50 parts by weight or less of a water-soluble cellulose ether; a drug-containing particle having a drug-containing core and a coat portion obtained by coating the core with the coating composition; a solid preparation having the drug-containing particle; and a method for preparing a drug-containing particle having a step of coating the drug-containing core with the coating composition.Type: GrantFiled: January 9, 2014Date of Patent: July 6, 2021Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Takuya Yokosawa, Yuichi Nishiyama, Naosuke Maruyama
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Patent number: 11021628Abstract: Regarding coating of fine particles or the like, provided are a coating composition containing methyl cellulose having small adhesiveness, resistance to generation of lumps, ability to form uniform coating, and ability to form a coating composition easily with water of normal temperature; a method for producing the coating composition; and a solid preparation. More specifically provided are a coating composition including methyl cellulose having such a viscosity that a viscosity at 20° C. of a 2% by weight aqueous solution of the methyl cellulose is 1 to 15 mPa·s and having such a dissolution start temperature that a dissolution start temperature of a 12% by weight aqueous liquid of the methyl cellulose is 10 to 25° C. and a solvent; a solid preparation obtained by coating of the coating composition; and the like.Type: GrantFiled: March 6, 2017Date of Patent: June 1, 2021Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Naosuke Maruyama, Takuya Yokosawa, Akira Kitamura
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Patent number: 10980747Abstract: A composition which is used for the production of a solid preparation exhibiting a small variation of dissolution even at a low content of hydroxypropyl methyl cellulose (HPMC), and others. More specifically, provided are a composition for a solid preparation, the composition including HPMC having a polydispersity of 4.0 or more, as determined by absolute molecular weight measurement, and having a viscosity at 20° C. of 1,500 to 15,0000 mPa·s, as determined in a 2% by mass aqueous solution thereof, and an active ingredient; the solid preparation including the composition; and a method for producing a tablet including a step of dry-mixing said HPMC with an active ingredient to obtain a mixture, or granulating a mixture including said HPMC and an active ingredient to obtain a granulated product, and a step of tableting the mixture or the granulated product to obtain a tablet.Type: GrantFiled: November 16, 2018Date of Patent: April 20, 2021Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Takuya Yokosawa
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Patent number: 10696751Abstract: Provided are a solid preparation comprising an alkyl cellulose which provides excellent moldability and disintegrability even in a small amount of the alkyl cellulose, and a production method therefor. Specifically, provided are a solid preparation having an alkyl cellulose having a specific surface area by BET method of 0.5 to 10.0 m2/g and a dissolution start temperature of 5 to 27° C.; and a method for producing a solid preparation having the steps of: mixing a cellulose pulp and a first alkali metal hydroxide solution with stirring to obtain alkali cellulose, reacting the alkali cellulose with an alkylating agent to obtain a first reaction mixture, mixing the first reaction mixture and a second alkali metal hydroxide solution with stirring and without further addition of any alkylating agent to obtain a second reaction mixture, and pulverizing an alkyl cellulose isolated from the second reaction mixture to obtain an alkyl cellulose.Type: GrantFiled: March 6, 2017Date of Patent: June 30, 2020Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Takuya Yokosawa, Naosuke Maruyama, Akira Kitamura
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Patent number: 10550202Abstract: There is provided is a hydroxyalkyl alkyl cellulose exhibiting good flowability and high compressibility. More specifically, provided are a hydroxyalkyl alkyl cellulose having a volume-based average particle diameter, determined by dry laser diffractometry, of 50 to 100 ?m, and having, on a basis of a dynamic image analysis to divide all particles into fine particles, spherical particles and fibrous particles, a volume fraction of the fibrous particles consisting of long and short fibrous particles relative to all of the particles of 45 to 70%, and a volume fraction of the fine particles relative to all of the particles of less than 2.0%; a solid preparation including the hydroxyalkyl alkyl cellulose; and others.Type: GrantFiled: October 2, 2017Date of Patent: February 4, 2020Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Takuya Yokosawa, Taishi Kitaguchi, Yasuyuki Hirama, Akira Kitamura
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Patent number: 10532029Abstract: Provided are an alkyl cellulose excellent in formability when added even in a small amount and not causing marked delay in disintegration; a solid preparation comprising it; and a method for producing the solid preparation. More specifically, provided are an alkyl cellulose for use in tableting, the alkyl cellulose having a specific surface area of from 0.5 to 10.0 m2/g as measured by BET method and a solid preparation comprising the alkyl cellulose. Also provided is a method for producing the alkyl cellulose, comprising the steps of: bringing pulp into contact with an alkali metal hydroxide solution to obtain alkali cellulose, reacting the alkali cellulose with an etherifying agent to obtain a first alkyl cellulose, pulverizing the first alkyl cellulose, and depolymerizing the pulverized first alkyl cellulose through hydrolysis with an acid catalyst or through oxidative decomposition with an oxidant to obtain a second alkyl cellulose.Type: GrantFiled: July 27, 2018Date of Patent: January 14, 2020Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Takuya Yokosawa, Naosuke Maruyama
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Patent number: 10314786Abstract: Provided is a hydroxyalkyl alkyl cellulose exhibiting good flowability and high compressibility. More specifically, there are provided a hydroxyalkyl alkyl cellulose having a volume-based average particle size, determined by dry laser diffractometry, of more than 100 ?m and not more than 150 ?m; and after dividing all particles into fine particles, spherical particles and fibrous particles by a dynamic image analysis, a volume fraction of the fibrous particles relative to all of the particles of more than 40% and not more than 50%, and a volume fraction of the fine particles relative to all of the particles of less than 2.0%; a solid preparation including the hydroxyalkyl alkyl cellulose; and others.Type: GrantFiled: October 2, 2017Date of Patent: June 11, 2019Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Taishi Kitaguchi, Yasuyuki Hirama, Takuya Yokosawa, Akira Kitamura
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Publication number: 20190160012Abstract: A composition which is used for the production of a solid preparation exhibiting a small variation of dissolution even at a low content of hydroxypropyl methyl cellulose (HPMC), and others. More specifically, provided are a composition for a solid preparation, the composition including HPMC having a polydispersity of 4.0 or more, as determined by absolute molecular weight measurement, and having a viscosity at 20° C. of 1,500 to 15,0000 mPa·s, as determined in a 2% by mass aqueous solution thereof, and an active ingredient; the solid preparation including the composition; and a method for producing a tablet including a step of dry-mixing said HPMC with an active ingredient to obtain a mixture, or granulating a mixture including said HPMC and an active ingredient to obtain a granulated product, and a step of tableting the mixture or the granulated product to obtain a tablet.Type: ApplicationFiled: November 16, 2018Publication date: May 30, 2019Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Takuya YOKOSAWA
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Publication number: 20180333361Abstract: Provided are an alkyl cellulose excellent in formability when added even in a small amount and not causing marked delay in disintegration; a solid preparation comprising it; and a method for producing the solid preparation. More specifically, provided are an alkyl cellulose for use in tableting, the alkyl cellulose having a specific surface area of from 0.5 to 10.0 m2/g as measured by BET method and a solid preparation comprising the alkyl cellulose. Also provided is a method for producing the alkyl cellulose, comprising the steps of: bringing pulp into contact with an alkali metal hydroxide solution to obtain alkali cellulose, reacting the alkali cellulose with an etherifying agent to obtain a first alkyl cellulose, pulverizing the first alkyl cellulose, and depolymerizing the pulverized first alkyl cellulose through hydrolysis with an acid catalyst or through oxidative decomposition with an oxidant to obtain a second alkyl cellulose.Type: ApplicationFiled: July 27, 2018Publication date: November 22, 2018Applicant: Shin-Etsu Chemical Co., Ltd.Inventors: Takuya Yokosawa, Naosuke Maruyama
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Patent number: 10058617Abstract: Provided is a composition for forming a film, the composition not having completely dissolved hydroxypropyl methyl cellulose (HPMC), and enabling formation of the film having a uniform thickness by suppressing the viscosity increase of the composition around an immersion temperature of 50° C. More specifically provided is a composition for forming a film, the composition comprising hypromellose having methoxy group content of 28.0 to 30.0% by weight and hydroxypropoxy group content of 7.6 to 8.5% by weight, wherein a 2% by weight aqueous solution of the hypromellose provides a viscosity at 20° C. of 4.0 to 6.5 mPa·s, a 20% by weight dispersion of the hypromellose provides a viscosity at 50° C. of 2,000 to 11,000 mPa·s, and a 20% by weight aqueous solution of the hypromellose provides a gelation temperature of 54 to 57° C.; and a solvent.Type: GrantFiled: December 13, 2016Date of Patent: August 28, 2018Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Tatsuya Yamashita, Takuya Yokosawa, Naosuke Maruyama, Mitsuo Narita
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Patent number: 10058509Abstract: Provided are an alkyl cellulose excellent in formability when added even in a small amount and not causing marked delay in disintegration; a solid preparation comprising it; and a method for producing the solid preparation. More specifically, provided are an alkyl cellulose for use in tableting, the alkyl cellulose having a specific surface area of from 0.5 to 10.0 m2/g as measured by BET method and a solid preparation comprising the alkyl cellulose. Also provided is a method for producing the alkyl cellulose, comprising the steps of: bringing pulp into contact with an alkali metal hydroxide solution to obtain alkali cellulose, reacting the alkali cellulose with an etherifying agent to obtain a first alkyl cellulose, pulverizing the first alkyl cellulose, and depolymerizing the pulverized first alkyl cellulose through hydrolysis with an acid catalyst or through oxidative decomposition with an oxidant to obtain a second alkyl cellulose.Type: GrantFiled: June 14, 2017Date of Patent: August 28, 2018Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Takuya Yokosawa, Naosuke Maruyama
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Publication number: 20180098941Abstract: Provided is a hydroxyalkyl alkyl cellulose exhibiting good flowability and high compressibility. More specifically, there are provided a hydroxyalkyl alkyl cellulose having a volume-based average particle size, determined by dry laser diffractometry, of more than 100 ?m and not more than 150 ?m; and after dividing all particles into fine particles, spherical particles and fibrous particles by a dynamic image analysis, a volume fraction of the fibrous particles relative to all of the particles of more than 40% and not more than 50%, and a volume fraction of the fine particles relative to all of the particles of less than 2.0%; a solid preparation including the hydroxyalkyl alkyl cellulose; and others.Type: ApplicationFiled: October 2, 2017Publication date: April 12, 2018Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Taishi KITAGUCHI, Yasuyuki HIRAMA, Takuya YOKOSAWA, Akira KITAMURA
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Publication number: 20180100028Abstract: There is provided is a hydroxyalkyl alkyl cellulose exhibiting good flowability and high compressibility. More specifically, provided are a hydroxyalkyl alkyl cellulose having a volume-based average particle diameter, determined by dry laser diffractometry, of 50 to 100 ?m, and having, on a basis of a dynamic image analysis to divide all particles into fine particles, spherical particles and fibrous particles, a volume fraction of the fibrous particles consisting of long and short fibrous particles relative to all of the particles of 45 to 70%, and a volume fraction of the fine particles relative to all of the particles of less than 2.0%; a solid preparation including the hydroxyalkyl alkyl cellulose; and others.Type: ApplicationFiled: October 2, 2017Publication date: April 12, 2018Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Takuya YOKOSAWA, Taishi KITAGUCHI, Yasuyuki HIRAMA, Akira KITAMURA
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Patent number: 9926385Abstract: Provided are a method for producing a water-soluble cellulose ether having a low degree of polymerization and enhanced whiteness, and the like. The method includes the steps of: bringing a pulp powder having a multiplication product of less than 0.004 mm2 which is obtained by multiplying a number-average fiber length by a number-average fiber width, each measured with a Kajaani fiber length analyzer, into contact with an alkali metal hydroxide to obtain an alkali cellulose; reacting the alkali cellulose with an etherifying agent to obtain a crude water-soluble cellulose ether having a high degree of polymerization; purifying the crude water-soluble cellulose ether; drying the purified water-soluble cellulose ether; grinding the dried water-soluble cellulose ether into a water-soluble cellulose ether powder; and depolymerizing the water-soluble cellulose ether powder to obtain the water-soluble cellulose ether having a low degree of polymerization.Type: GrantFiled: July 31, 2014Date of Patent: March 27, 2018Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Akira Kitamura, Mitsuo Narita, Takuya Yokosawa, Yuichi Nishiyama
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Publication number: 20170273910Abstract: Provided are an alkyl cellulose excellent in formability when added even in a small amount and not causing marked delay in disintegration; a solid preparation comprising it; and a method for producing the solid preparation. More specifically, provided are an alkyl cellulose for use in tableting, the alkyl cellulose having a specific surface area of from 0.5 to 10.0 m2/g as measured by BET method and a solid preparation comprising the alkyl cellulose. Also provided is a method for producing the alkyl cellulose, comprising the steps of: bringing pulp into contact with an alkali metal hydroxide solution to obtain alkali cellulose, reacting the alkali cellulose with an etherifying agent to obtain a first alkyl cellulose, pulverizing the first alkyl cellulose, and depolymerizing the pulverized first alkyl cellulose through hydrolysis with an acid catalyst or through oxidative decomposition with an oxidant to obtain a second alkyl cellulose.Type: ApplicationFiled: June 14, 2017Publication date: September 28, 2017Inventors: Takuya Yokosawa, Naosuke Maruyama