Patents by Inventor Tal Raz
Tal Raz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240102002Abstract: A system includes a plurality of drug libraries, at least one comprising multiple droplets of multiple drugs, each drug associated with a corresponding unique drug identifier in the system, and a live cell library comprising multiple live cells or live cell lines, each live cell associated with a corresponding unique cell or cell line identifier in the system. A plurality of junctions combining drug droplets from the drug libraries and a live cell from the live cell library. At least one of said drug libraries produces a random stream of heterogenous drug droplets, the drug droplets corresponding to drugs in said drug libraries.Type: ApplicationFiled: February 1, 2022Publication date: March 28, 2024Applicant: Hunter BioDiscovery, Inc.Inventors: Tal Raz, Xiao Wang, Boryana Zhelyazkova PURSLEY, David Allan Weitz
-
Patent number: 10941445Abstract: The present invention relates to methods of target nucleic acid amplification and uses thereof in methods of sequencing, or other down-stream applications such a genotyping or cloning. More specifically, the methods relate to methods of target nucleic acid amplification through the use of a universal hairpin primer.Type: GrantFiled: March 20, 2018Date of Patent: March 9, 2021Assignee: Bio-Rad Laboratories, Inc.Inventors: Tal Raz, Pascaline Mary
-
Patent number: 10533212Abstract: The present invention generally pertains to methods for detecting the presence or absence of a particular nucleic acid sequence. The present invention generally relates to incorporating a detector into a target nucleic acid, adding an oligonucleotide probe, polymerase enzyme and an inhibitor to the reaction, and detecting interference of the oligonucleotide probe with the inhibitor as an indication of the presence of a particular target nucleic acid sequence as well as kits encompassing the same.Type: GrantFiled: January 17, 2017Date of Patent: January 14, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: Tal Raz, Pascaline Mary
-
Patent number: 10343167Abstract: The present invention provides a microfluidic system, method and kit for performing assays. The system may comprise a microfluidic device and a detector, wherein the assay yields results that may be read by a detector and analyzed by the system. The assay may comprise one or more chemical or biological reaction against, or performed on, a sample or multiple samples. The sample(s) may become larger and/or smaller during the performance of the assay. The sample(s) may be present within a vehicle, or on a carrier within a vehicle, in the microfluidic device, and wherein the vehicle may become larger and/or smaller during the performance of the assay. The assay may be a cascading assay comprising a series of multiple assays, wherein each assay may be the same or different, and wherein each assay in the series of multiple assays may further comprise one or more process or step.Type: GrantFiled: August 30, 2017Date of Patent: July 9, 2019Assignee: Bio-Rad Laboratories, Inc.Inventors: Adnan Esmail, Tal Raz, John Healy, Tony Hung, Sepehr Kiani, Pascaline Mary
-
Publication number: 20180274029Abstract: The present invention relates to methods of target nucleic acid amplification and uses thereof in methods of sequencing, or other down-stream applications such a genotyping or cloning. More specifically, the methods relate to methods of target nucleic acid amplification through the use of a universal hairpin primer.Type: ApplicationFiled: March 20, 2018Publication date: September 27, 2018Inventors: Tal RAZ, Pascaline MARY
-
Publication number: 20170361322Abstract: The present invention provides a microfluidic system, method and kit for performing assays. The system may comprise a microfluidic device and a detector, wherein the assay yields results that may be read by a detector and analyzed by the system. The assay may comprise one or more chemical or biological reaction against, or performed on, a sample or multiple samples. The sample(s) may become larger and/or smaller during the performance of the assay. The sample(s) may be present within a vehicle, or on a carrier within a vehicle, in the microfluidic device, and wherein the vehicle may become larger and/or smaller during the performance of the assay. The assay may be a cascading assay comprising a series of multiple assays, wherein each assay may be the same or different, and wherein each assay in the series of multiple assays may further comprise one or more process or step.Type: ApplicationFiled: August 30, 2017Publication date: December 21, 2017Inventors: Adnan ESMAIL, Tal RAZ, John HEALY, Tony HUNG, Sepehr KIANI, Pascaline MARY
-
Patent number: 9821312Abstract: The present invention provides a microfluidic system, method and kit for performing assays. The system may comprise a microfluidic device and a detector, wherein the assay yields results that may be read by a detector and analyzed by the system. The assay may comprise one or more chemical or biological reaction against, or performed on, a sample or multiple samples. The sample(s) may become larger and/or smaller during the performance of the assay. The sample(s) may be present within a vehicle, or on a carrier within a vehicle, in the microfluidic device, and wherein the vehicle may become larger and/or smaller during the performance of the assay. The assay may be a cascading assay comprising a series of multiple assays, wherein each assay may be the same or different, and wherein each assay in the series of multiple assays may further comprise one or more process or step.Type: GrantFiled: September 12, 2013Date of Patent: November 21, 2017Assignee: Bio-Rad Laboratories, Inc.Inventors: Adnan Esmail, John Healy, Tony Hung, Sepehr Kiani, Pascaline Mary, Tal Raz
-
Publication number: 20170226568Abstract: The present invention generally pertains to methods for detecting the presence or absence of a particular nucleic acid sequence. The present invention generally relates to incorporating a detector into a target nucleic acid, adding an oligonucleotide probe, polymerase enzyme and an inhibitor to the reaction, and detecting interference of the oligonucleotide probe with the inhibitor as an indication of the presence of a particular target nucleic acid sequence as well as kits encompassing the same.Type: ApplicationFiled: January 17, 2017Publication date: August 10, 2017Inventors: Tal Raz, Pascaline Mary
-
Patent number: 9581549Abstract: The present invention generally pertains to methods for detecting the presence or absence of a particular nucleic acid sequence. The present invention generally relates to incorporating a detector into a target nucleic acid, adding an oligonucleotide probe, polymerase enzyme and an inhibitor to the reaction, and detecting interference of the oligonucleotide probe with the inhibitor as an indication of the presence of a particular target nucleic acid sequence as well as kits encompassing the same.Type: GrantFiled: December 7, 2011Date of Patent: February 28, 2017Assignee: GnuBio, Inc.Inventors: Tal Raz, Pascaline Mary
-
Publication number: 20160076082Abstract: Methods and compositions for blocking polymerase extension from 3 ends of amplicons are provided.Type: ApplicationFiled: April 28, 2014Publication date: March 17, 2016Inventors: Tal Raz, Pascaline Mary
-
Publication number: 20150209785Abstract: The present invention provides a microfluidic system, method and kit for performing assays. The system may comprise a microfluidic device and a detector, wherein the assay yields results that may be read by a detector and analyzed by the system. The assay may comprise one or more chemical or biological reaction against, or performed on, a sample or multiple samples. The sample(s) may become larger and/or smaller during the performance of the assay. The sample(s) may be present within a vehicle, or on a carrier within a vehicle, in the microfluidic device, and wherein the vehicle may become larger and/or smaller during the performance of the assay. The assay may be a cascading assay comprising a series of multiple assays, wherein each assay may be the same or different, and wherein each assay in the series of multiple as says may further comprise one or more process or step.Type: ApplicationFiled: September 12, 2013Publication date: July 30, 2015Applicant: GnuBio, Inc.Inventors: Adnan Esmail, John Healy, Tony Hung, Sepehr Kiani, Pascaline Mary, Tal Raz
-
Publication number: 20150045258Abstract: The present invention generally pertains to methods for the addition of one or more nucleic acid adaptors to a PCR product. The present invention generally relates to a method for the cascaded, highly specific addition of universal nucleic acid adapters to one or more target nucleic acids in a single PCR amplification reaction, as well as a kit encompassing the same.Type: ApplicationFiled: February 8, 2013Publication date: February 12, 2015Inventors: Tal Raz, Haifa Ghandour, Pascaline Mary
-
Publication number: 20130344485Abstract: The present invention generally pertains to methods for detecting the presence or absence of a particular nucleic acid sequence. The present invention generally relates to incorporating a detector into a target nucleic acid, adding an oligonucleotide probe, polymerase enzyme and an inhibitor to the reaction, and detecting interference of the oligonucleotide probe with the inhibitor as an indication of the presence of a particular target nucleic acid sequence as well as kits encompassing the same.Type: ApplicationFiled: December 7, 2011Publication date: December 26, 2013Applicant: GNUBIO, INC.Inventors: Tal Raz, Mary Pascaline
-
Publication number: 20110129827Abstract: The invention takes a unique approach to transcript analysis that provides a novel DGE technology based on single-molecule sequencing. More particularly, the invention relates to methods and compositions for analyzing and identifying genes and gene expression and transcript profiles using a DGE-based technology and single molecule sequencing that does not require amplification or fragmentation.Type: ApplicationFiled: April 3, 2009Publication date: June 2, 2011Applicant: Helicos Biosciences CorporationInventors: Marie Causey, Tal Raz, Doron Lipson
-
Publication number: 20100159533Abstract: Methods and kits for selective preparing cDNA relatively free of sequences found in rRNA and subcellular RNAs are disclosed. The methods and kits utilize approximately 200 hexamer sequences which target messenger RNA. The methods and kits are useful in preparing samples for sequencing analysis, especially when performing single molecule sequencing by synthesis.Type: ApplicationFiled: November 24, 2009Publication date: June 24, 2010Applicant: HELICOS BIOSCIENCES CORPORATIONInventors: Doron Lipson, Tal Raz, John F. Thompson
-
Publication number: 20090181369Abstract: The present invention is directed to methods to determine the likelihood of therapeutic effectiveness of a farnesyl transferase inhibitor (FTI). The method comprises determining whether the gene encoding the farnesyl transferase beta subunit (FNTB) of said patient comprises at least one nucleic acid variance that causes an alteration in an amino acid residue. The change in the amino acid residue is associated with resistance to a FTI. The absence of at least one variance indicates that the FTI is likely to be effective.Type: ApplicationFiled: May 30, 2006Publication date: July 16, 2009Inventors: George Q Daley, Tal Raz, Mohammad Azam