Patents by Inventor Talar Tokatlian

Talar Tokatlian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
    Patent number: 11964026
    Abstract: Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.
    Type: Grant
    Filed: August 22, 2022
    Date of Patent: April 23, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Antonio Eric Barberio, Santiago Correa Echavarria, Mariane Bandeira Melo, Talar Tokatlian, Erik Christopher Dreaden, Paula T. Hammond, Darrell J. Irvine
  • COMPOSITIONS AND METHODS FOR TREATING MESOTHELIN POSITIVE CANCERS
    Publication number: 20230277590
    Abstract: The disclosure provides immune cells comprising a first activator receptor specific to mesothelin and a second inhibitory receptor specific to a ligand that has been lost in a mesothelin-positive cancer cell, and methods of making and using same for the treatment of cancer.
    Type: Application
    Filed: December 7, 2022
    Publication date: September 7, 2023
    Inventors: Carl Alexander Kamb, Dora Toledo Warshaviak, Talar Tokatlian, Agnes Hamburger
  • LAYER-BY-LAYER NANOPARTICLES FOR CYTOKINE THERAPY IN CANCER TREATMENT
    Publication number: 20230201367
    Abstract: Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.
    Type: Application
    Filed: August 22, 2022
    Publication date: June 29, 2023
    Inventors: Antonio E. Barberio, Santiago Correa Echavarria, Mariane Bandeira Melo, Talar Tokatlian, Erik Christopher Dreaden, Paula T. Hammond, Darrell J. Irvine
  • Compositions and methods for treating mesothelin positive cancers
    Patent number: 11602543
    Abstract: The disclosure provides immune cells comprising a first activator receptor specific to mesothelin and a second inhibitory receptor specific to a ligand that has been lost in a mesothelin-positive cancer cell, and methods of making and using same for the treatment of cancer.
    Type: Grant
    Filed: May 10, 2022
    Date of Patent: March 14, 2023
    Assignee: A2 Biotherapeutics, Inc.
    Inventors: Carl Alexander Kamb, Dora Toledo Warshaviak, Talar Tokatlian, Agnes Hamburger
  • COMPOSITIONS AND METHODS FOR TREATING MESOTHELIN POSITIVE CANCERS
    Publication number: 20220370497
    Abstract: The disclosure provides immune cells comprising a first activator receptor specific to mesothelin and a second inhibitory receptor specific to a ligand that has been lost in a mesothelin-positive cancer cell, and methods of making and using same for the treatment of cancer.
    Type: Application
    Filed: May 10, 2022
    Publication date: November 24, 2022
    Inventors: Carl Alexander Kamb, Dora Toledo Warshaviak, Talar Tokatlian, Agnes Hamburger
  • Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
    Patent number: 11419947
    Abstract: Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: August 23, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Antonio Eric Barberio, Santiago Correa Echavarria, Mariane Bandeira Melo, Talar Tokatlian, Erik Christopher Dreaden, Paula T. Hammond, Darrell J. Irvine
  • FERRITIN NANOPARTICLE DISPLAYING AN HIV TRIMER
    Publication number: 20210363194
    Abstract: The present invention relates to glycosylate HIV timer nanoparticles fused to self-assembling ferritin proteins which may be utilized as immunogens to enhance trafficking to lymph nodes and germinal centers and to heighten immune responses.
    Type: Application
    Filed: June 5, 2019
    Publication date: November 25, 2021
    Inventors: Talar Tokatlian, Benjamin J. Read, Daniel W. Kulp, Sergey Menis, Jon M. Steichen, William R. Schief, Darrell J. Irvine
  • LAYER-BY-LAYER NANOPARTICLES FOR CYTOKINE THERAPY IN CANCER TREATMENT
    Publication number: 20190125895
    Abstract: Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.
    Type: Application
    Filed: October 30, 2018
    Publication date: May 2, 2019
    Inventors: Antonio Eric Barberio, Santiago Correa Echavarria, Mariane Bandeira Melo, Talar Tokatlian, Erik Christopher Dreaden, Paula T. Hammond, Darrell J. Irvine