Patents by Inventor Taly Spivak-Kroizman

Taly Spivak-Kroizman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adaptor protein FRS2 and related products and methods
    Patent number: 7135320
    Abstract: The present invention relates generally to a newly identified adaptor protein FRS2 and related products and methods. FRS2 links protein kinases to activating partners in cells. The invention also relates to nucleic acid molecules encoding portions of FRS2, nucleic acid vectors containing FRS2 related nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that enhance or block FRS2 interactions with natural binding partners. Also disclosed are methods for diagnosing abnormal conditions in an organism with FRS2 related molecules or compounds.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: November 14, 2006
    Assignee: New York University
    Inventors: Haruhiko Kouhara, Taly Spivak-Kroizman, Irit Lax, Joseph Schlessinger
  • Isolated nucleic acid molecule encoding a variant human eukaryotic Intiation Factor 4E protein
    Patent number: 6596854
    Abstract: The invention provides a method of purifying human eIF-4E protein and amino acid sequence variants thereof having altered binding affinity for capped RNA. Using the described purification, amino acid sequence variants can readily be expressed, purified and tested. Both lowered and enhanced binding affinity variants are useful for modifying protein expression levels in vivo and in vitro.
    Type: Grant
    Filed: April 14, 2001
    Date of Patent: July 22, 2003
    Assignee: Emory University
    Inventors: Curt H. Hagedorn, Taly Spivak-Kroizman, Yiping Xie
  • Adaptor protein FRS2 and related products and methods
    Publication number: 20020086972
    Abstract: The present invention relates generally to a newly identified adaptor protein FRS2 and related products and methods. FRS2 links protein kinases to activating partners in cells. The invention also relates to nucleic acid molecules encoding portions of FRS2, nucleic acid vectors containing FRS2 related nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that enhance or block FRS2 interactions with natural binding partners. Also disclosed are methods for diagnosing abnormal conditions in an organism with FRS2 related molecules or compounds.
    Type: Application
    Filed: December 8, 2000
    Publication date: July 4, 2002
    Inventors: Haruhiko Kouhara, Taly Spivak-Kroizman, Irit Lax, Joseph Schlessinger
  • Purified eukaryotic-initiation factor 4E
    Publication number: 20020048804
    Abstract: The invention provides a method of purifying human eIF-4E protein and amino acid sequence variants thereof having altered binding affinity for capped RNA. Using the described purification, amino acid sequence variants can readily be expressed, purified and tested. Both lowered and enhanced binding affinity variants are useful for modifying protein expression levels in vivo and in vitro.
    Type: Application
    Filed: May 14, 2001
    Publication date: April 25, 2002
    Inventors: Curt H. Hagedorn, Taly Spivak-Kroizman, Yiping Xie
  • Adaptor protein FRS2 and related products and methods
    Patent number: 6310181
    Abstract: The present invention relates generally to a newly identified adaptor protein FRS2 and related products and methods. FRS2 links protein kinases to activating partners in cells. The invention also relates to nucleic acid molecules encoding portions of FRS2, nucleic acid vectors containing FRS2 related nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that enhance or block FRS2 interactions with natural binding partners. Also disclosed are methods for diagnosing abnormal conditions in an organism with FRS2 related molecules or compounds.
    Type: Grant
    Filed: December 1, 1997
    Date of Patent: October 30, 2001
    Assignee: New York University Medical Center
    Inventors: Haruhiko Kouhara, Taly Spivak-Kroizman, Irit Lax, Joseph Schlessinger
  • Purified eukaryotic-initiation factor 4E having altered RNA binding affinity
    Patent number: 6232442
    Abstract: The invention provides a method of purifying human eIF-4E protein and amino acid sequence variants thereof having altered binding affinity for capped RNA. Using the described purification, amino acid sequence variants can readily be expressed, purified and tested. Both lowered and enhanced binding affinity variants are useful for modifying protein expression levels in vivo and in vitro.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: May 15, 2001
    Assignee: Emory University
    Inventors: Curt H. Hagedorn, Taly Spivak-Kroizman, Yiping Xie