Abstract: Compounds represented by formula (I): wherein each symbol is as defined in the description, and pharmaceutically acceptable salts thereof are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.

Abstract: A process for producing a reinforcing-fiber strip substrate having a circular-arc part includes contacting one surface of a strip-shaped, unidirectional reinforcing-fiber substrate formed by arranging a plurality of reinforcing-fiber strands in one direction in parallel with each other with a flexible member; deforming the unidirectional reinforcing-fiber substrate into a circular-arc shape by deforming at least a part of the flexible member into a circular-arc shape in a direction extending along its contact surface with the unidirectional reinforcing-fiber substrate; and thereafter, separating the flexible member from the unidirectional reinforcing-fiber substrate having been deformed.

Abstract: The present invention provides a blood glucose elevation inhibitor having a serine protease inhibitory action, which is a novel therapeutic or prophylactic agent for obesity. A compound represented by the following formula (I) wherein each symbol is as described in the specification, or a pharmaceutically acceptable salt thereof.

Abstract: An apparatus for forming, on a strip-shaped laminate of multiple reinforcing fiber sheets superimposed one upon another, two flexures with respect to the cross-section configuration thereof, wherein in the forming of the two flexures with the use of two s flexure forming dies independent from each other, respectively, the two flexure forming dies are arranged so that the relative distance of the two flexure forming dies is changeable in the direction perpendicular to the longitudinal direction of the strip-shaped laminate. This apparatus can be effectively utilized in the production of a reinforcing fiber molding with changing of the distance between the two flexures namely, width of web portion or gauge between two flange portions from the strip-shaped laminate, or the production of fiber reinforced resin (FRP) molding therefrom.

Abstract: Compounds represented by formula (I): wherein each symbol is as defined in the description, and pharmaceutically acceptable salts thereof are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.

Abstract: Compounds represented by the following formula (I), are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.

Abstract: Compounds represented by formula (I): wherein each symbol is as defined in the description, and pharmaceutically acceptable salts thereof are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.

Abstract: A method for preparing a phenylalanine derivative having a quinazoline-dione ring represented by the following formula (1) or a pharmaceutically acceptable salt thereof, comprising the following steps (a), (b) and (c): (a) reacting an acyl phenylalanine derivative represented by the following formula (2): with a carbonyl group-introducing reagent and a specific anthranilic acid derivative to thus form the corresponding carboxy-asymmetric urea derivative; (b) converting the carboxy-asymmetric urea derivative into the corresponding quinazoline-dione derivative in the presence of a carboxyl group-activating agent: (c) if desired, substituting an N-alkyl group for the hydrogen atom bonded to the nitrogen atom present in the quinazoline-dione ring of the quinazoline-dione derivative using an N-alkylation agent and then deprotecting the resulting product, when the substituent R3? which is a group corresponding to R3 is protected.

Abstract: A preform for the molding of a fiber-reinforced resin beam, the preform comprising: a reinforcing-fiber beam which has been formed from a reinforcing-fiber base made up of many reinforcing fibers and has a cross-sectional shape comprising at least one linear part and at least one curved part connected to the linear part; and a release sheet bonded and united through an adhesive resin to at least part of a surface of the reinforcing-fiber base along the lengthwise direction for the base. A process for producing a preform comprises: a step in which a continuous flat reinforcing-fiber base having a release sheet bonded and united to a surface thereof is shaped so that the cross-sectional shape of the base comes to have a curved part to thereby produce a preshaped object; and a preshaped-object uniting step in which the preshaped object is bonded and united to another preshaped object.

Abstract: A preform for the molding of a fiber-reinforced resin beam includes a reinforcing-fiber beam which has been formed from a reinforcing-fiber base made up of many reinforcing fibers and has a cross-sectional shape with at least one linear part and at least one curved part connected to the linear part; and a release sheet bonded and united through an adhesive resin to at least part of a surface of the reinforcing-fiber base along the lengthwise direction for the base. A process for producing a preform includes shaping a continuous flat reinforcing-fiber base having a release sheet bonded and united to a surface thereof so that the cross-sectional shape of the base has a curved part to thereby produce a preshaped object; and bonding and uniting the preshaped object to another preshaped object.

Abstract: A process for producing a sheet-shaped prepreg includes: a fiber bundle introduction step in which tape-shaped reinforcing fiber bundles are disposed in a multilayer arrangement in the thickness direction and introduced into a die to which a molten thermoplastic resin has been supplied; a fiber bundle thickness reduction step in which each of the tape-shaped reinforcing fiber bundles is widened by means of spreading to reduce the thickness; a resin impregnation step in which the tape-shaped reinforcing fiber bundles are impregnated with the molten resin in the die; and a lamination step in which the plurality of resin-impregnated tape-shaped reinforcing fiber bundles are laminated in the die.

Abstract: Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to ?4 integrin. They are used as therapeutic agents for various diseases concerning ?4 integrin.

Abstract: Compounds represented by formula (I): wherein each symbol is as defined in the description, and pharmaceutically acceptable salts thereof are useful as hyperglycemic inhibitors having a serine protease inhibitory action and as prophylactic or therapeutic drugs for diabetes.

Abstract: A process for producing a beam member formed by a reinforcing fiber base material which has a web portion and at least a pair of flange portions extending to both sides via at least a branching point from the web portion, at a cross-sectional surface orthogonal to a longitudinal direction of the beam member, and by a shaped filler which fills a gap having a wedge shape formed at the branching point, is provided. The shaped filler is produced by: (A) a filler supply process for supplying a filler member configured by reinforcing fibers; (B) a preshaping process for providing a preshaped filler having at least a wedge projection portion, by pressurizing the filler member by a preshaping mold; and (C) a filler deforming process for providing a shaped filler by deforming the preshaped filler.

Abstract: A method of forming, on a strip-shaped laminate of multiple reinforcing fiber sheets superimposed one upon another, two flexures with respect to the cross-section configuration thereof, wherein in the forming of the two flexures with the use of two flexure forming dies independent from each other, respectively, the two flexure forming dies are arranged so that the relative distance of the two flexure forming dies is changeable in the direction perpendicular to the longitudinal direction of the strip-shaped laminate. This method can be effectively utilized in the production of a reinforcing fiber molding with changing of the distance between the two flexures namely, width of web portion or gauge between two flange portions from the strip-shaped laminate, or the production of fiber reinforced resin (FRP) molding therefrom.

Abstract: A process for producing a reinforcing woven fabric includes sticking a resin material on at least one surface of a fabric substrate including a plurality of reinforcing fiber bundles and varying the relative position of a plurality of reinforcing fiber bundles to peel the resin material stuck over two or more reinforcing fiber bundles from a part of the two or more reinforcing fiber bundles.

Abstract: Amide derivatives represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa-, —(CRbRb?)m-, and the like; m is 0 to 4; and R1 to R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group, a nitro group, a carboxyl group, a formyl group, a hydroxyl group, an ammonium group, an alkyl group optionally having one or more substituents, -ZR18 and the like, Z is —O—, —S(O)p-, —S(O)pO—, —NH—, —NR19-, and the like; or a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof may be applied to pharmaceutical use such as anti-inflammatory and analgesic action and the like.

Abstract: A method of forming, on a strip-shaped laminate of multiple reinforcing fiber sheets superimposed one upon another, two flexures with respect to the cross-section configuration thereof, wherein in the forming of the two flexures with the use of two flexure forming dies independent from each other, respectively, the two flexure forming dies are arranged so that the relative distance of the two flexure forming dies is changeable in the direction perpendicular to the longitudinal direction of the strip-shaped laminate. This method can be effectively utilized in the production of a reinforcing fiber molding with changing of the distance between the two flexures namely, width of web portion or gauge between two flange portions from the strip-shaped laminate, or the production of fiber reinforced resin (FRP) molding therefrom.

Abstract: A method for preparing a phenylalanine derivative having a quinazoline-dione ring represented by the following formula (1) or a pharmaceutically acceptable salt thereof, comprising the following steps (a), (b) and (c): (a) reacting an acyl phenylalanine derivative represented by the following formula (2): with a carbonyl group-introducing reagent and a specific anthranilic acid derivative to thus form the corresponding carboxy-asymmetric urea derivative; (b) converting the carboxy-asymmetric urea derivative into the corresponding quinazoline-dione derivative in the presence of a carboxyl group-activating agent: (c) if desired, substituting an N-alkyl group for the hydrogen atom bonded to the nitrogen atom present in the quinazoline-dione ring of the quinazoline-dione derivative using an N-alkylation agent and then deprotecting the resulting product, when the substituent R3? which is a group corresponding to R3 is protected.

Abstract: A process for producing a reinforcing-fiber strip substrate having a circular-arc part includes contacting one surface of a strip-shaped, unidirectional reinforcing-fiber substrate formed by arranging a plurality of reinforcing-fiber strands in one direction in parallel with each other with a flexible member; deforming the unidirectional reinforcing-fiber substrate into a circular-arc shape by deforming at least a part of the flexible member into a circular-arc shape in a direction extending along its contact surface with the unidirectional reinforcing-fiber substrate; and thereafter, separating the flexible member from the unidirectional reinforcing-fiber substrate having been deformed.