Patents by Inventor Tanja Ficko Trcek

Tanja Ficko Trcek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell culture medium and process for controlling ?-amidation and/or C-terminal amino acid cleavage of polypeptides
    Patent number: 10196601
    Abstract: The present invention is related to a cell culture medium for reducing the C-terminal heterogeneity of a polypeptide expressed in cell-culture, wherein the medium comprises at least one essential trace element in an effective amount, and to a cell culture process for reducing C-terminal heterogeneity of a protein, in which process an essential trace element is used.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: February 5, 2019
    Assignee: LEK PHARMACEUTICALS D.D.
    Inventor: Tanja Ficko Trcek
  • Production of glycoproteins with low N-glycolylneuraminic acid (Neu5Gc) content
    Patent number: 9562082
    Abstract: The present invention relates to a medium for the cultivation of eukaryotic cells, the medium comprising as (an) additive(s) DMSO, N-acetylmannosamine (NAcMan), N-acetylglucosamine (NAcGlc), or any combination of two or more of these additives, including the combination of NAcMan and NAcGlc.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: February 7, 2017
    Assignee: LEK PHARMACEUTICALS D.D.
    Inventor: Tanja Ficko Trcek
  • Production of glycoproteins with low N-glycolylneuraminic acid (NEU5GC) content
    Patent number: 9428562
    Abstract: The present invention relates to a medium for the cultivation of eukaryotic cells, the medium comprising as (an) additive(s) DMSO, N-acetylmannosamine (NAcMan), N-acetylglucosamine (NAcGlc), or any combination of two or more of these additives, including the combination of NAcMan and NAcGlc.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: August 30, 2016
    Assignee: LEK PHARMACEUTICALS D.D.
    Inventor: Tanja Ficko Trcek
  • CELL CULTURE MEDIUM AND PROCESS FOR CONTROLLING a-AMIDATION AND/OR C-TERMINAL AMINO ACID CLEAVAGE OF POLYPEPTIDES
    Publication number: 20160201028
    Abstract: The present invention is related to a cell culture medium for reducing the C-terminal heterogeneity of a polypeptide expressed in cell-culture, wherein the medium comprises at least one essential trace element in an effective amount, and to a cell culture process for reducing C-terminal heterogeneity of a protein, in which process an essential trace element is used.
    Type: Application
    Filed: August 20, 2014
    Publication date: July 14, 2016
    Inventor: Tanja FICKO TRCEK
  • PRODUCTION OF GLYCOPROTEINS WITH LOW N-GLYCOLYLNEURAMINIC ACID (NEU5GC) CONTENT
    Publication number: 20140288281
    Abstract: The present invention relates to a medium for the cultivation of eukaryotic cells, the medium comprising as (an) additive(s) DMSO, N-acetylmannosamine (NAcMan), N-acetylglucosamine (NAcGlc), or any combination of two or more of these additives, including the combination of NAcMan and NAcGlc.
    Type: Application
    Filed: May 16, 2014
    Publication date: September 25, 2014
    Applicant: LEK PHARMACEUTICALS D.D.
    Inventor: Tanja FICKO TRCEK
  • PRODUCTION OF GLYCOPROTEINS WITH LOW N-GLYCOLYLNEURAMINIC ACID (NEU5GC) CONTENT
    Publication number: 20140255989
    Abstract: The present invention relates to a medium for the cultivation of eukaryotic cells, the medium comprising as (an) additive(s) DMSO, N-acetylmannosamine (NAcMan), N-acetylglucosamine (NAcGlc), or any combination of two or more of these additives, including the combination of NAcMan and NAcGlc.
    Type: Application
    Filed: April 2, 2014
    Publication date: September 11, 2014
    Applicant: LEK Pharmaceuticals D.D.
    Inventor: Tanja FICKO TRCEK
  • Production of glycoproteins with low N-glycolylneuraminic acid (NEU5GC) content
    Patent number: 8728816
    Abstract: The present invention relates to a medium for the cultivation of eukaryotic cells, the medium comprising as (an) additive(s) DMSO, N-acetylmannosamine (NAcMan), N-acetylglucosamine (NAcGlc), or any combination of two or more of these additives, including the combination of NAcMan and NAcGlc.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: May 20, 2014
    Assignee: Lek Pharmaceuticals D.D.
    Inventor: Tanja Ficko Trcek
  • PRODUCTION OF GLYCOPROTEINS WITH LOW N-GLYCOLYLNEURAMINIC ACID (NEU5GC) CONTENT
    Publication number: 20120271041
    Abstract: The present invention relates to a medium for the cultivation of eukaryotic cells, the medium comprising as (an) additive(s) DMSO, N-acetylmannosamine (NAcMan), N-acetylglucosamine (NAcGlc), or any combination of two or more of these additives, including the combination of NAcMan and NAcGlc.
    Type: Application
    Filed: November 19, 2010
    Publication date: October 25, 2012
    Inventor: Tanja Ficko Trcek