Abstract: Provided are crystalline forms of a KRAS G12C inhibitor compound and to processes for their preparation. Furthermore, provided is pharmaceutical composition comprising said crystalline forms, and at least one pharmaceutically acceptable excipient. The pharmaceutical composition can be used as a medicament, in particular for the treatment of cancer, and KRAS G12C-mutant cancer.

Abstract: A device for automatic illumination and inspection of tubular probes, in particular stents, is proposed, with rotatable means for holding the probes that are to be inspected, with an electronic camera and associated lens, with a computer-based electronic imaging system, and with means for illuminating the probe that is to be inspected. The probe surfaces are illuminated by means of a combination of dark field illumination and transillumination.

Abstract: A hydrojet cleaning device (1) for cleaning the interior of a curved or coiled tubular device comprising a flexible hose (3) having one end connectable to a supply of pressurized water, and one end provided with a jet nozzle (5). The flexible hose is provided with a plurality of circumferential spacers (6) distributed over at least a section of the length of the hose. The spacers can for example comprise pulleys (11). Method of cleaning a coiled tubular line, such as a spiralled heat exchanger using such a hydrojet cleaning device. The distance between the spacers may, e.g., be such that the section of the hose between the spacers is entirely spaced from the interior wall of the tubular line wall over its full length.

Abstract: A device for automatic illumination and inspection of tubular probes, in particular stents, is proposed, with rotatable means for holding the probes that are to be inspected, with an electronic camera and associated lens, with a computer-based electronic imaging system, and with means for illuminating the probe that is to be inspected. The probe surfaces are illuminated by means of a combination of dark field illumination and transillumination.

Abstract: The present invention relates to the use of copolymers A containing a) from 50 to 99% by weight of at least one N-vinyllactam or N-vinylamine selected from the group consisting of N-vinylpyrrolidone, N-vinylpiperidone, N-vinylcaprolactam, N-vinylimidazole, methylated N-vinylimidazole, and N-vinylformamide, and b) from 1 to 50% by weight of at least one monomer selected from the group consisting of b1) C8-C30-alkyl esters of monoethylenically unsaturated C3-C8 carboxylic acids; b2) N—C8-C30-alkyl-substituted amides of monoethylenically unsaturated C3-C8 carboxylic acids; b3) N,N—C8-C30-dialkyl-substituted amides of monoethylenically unsaturated C3-C8 carboxylic acids; b4) vinyl esters of aliphatic C8-C30 carboxylic acids; and b5) C8-C30-alkyl vinyl ethers to produce membranes.

Abstract: Graft copolymers which contain at least one monoethylenically unsaturated monomer comprising at least one nitrogen-containing heterocycle are used as assistants for leather production.

Abstract: The use of copolymers containing a) from 60% to 99% by weight of at least one vinyllactam or N-vinylamine selected from the group consisting of N-vinylpyrrolidone, N-vinylpiperidone, N-vinylcaprolactam or N-vinylformamide, and b) from 1% to 40% by weight of at least one monomer of the general formula where b1) R1, R2, R3 each denote oxygen, C1-C4-alkyl, C6-aryl, C7-C10-alkylaryl and R4 denotes the general formula II X denotes oxygen, NH, NR (where R=R1) R5 denotes C1-C6-alkyl, phenyl, A denotes OH, NH2, NR2 (wheret R2=R1) R6, R7 R8 each denote hydrogen, C1-C4-alkyl n denotes an integer between 1 and 4 B, F each denote C, N D denotes C1-C4-alkyl, O, NH p denotes an integer between 0 and 15 E denotes N, O l, m each denote 0 or 1 R9, R10, R11 each denote hydrogen, C1-C4-alkyl, C6-C10-aryl, C7-C10-alkylaryl and s, q each denote an integer between 0 and 2. For E=nitrogen the s+q sum is equal to 1 or 2. For E=oxygen the s+q sum is equal to zero.

Abstract: A process for preparing copolymers which comprises copolymerizing (A) at least one ethylenically unsaturated dicarboxylic anhydride derived from at least one dicarboxylic acid having 4 to 8 carbon atoms, (B) at least one vinylaromatic compound, and (C) optionally at least one non-(A) ethylenically unsaturated comonomer containing at least one heteroatom, (D) reacting the copolymer with at least one compound of the formula I a or I b where A1 is C2-C20 alkylene, identical or different, R1 is C1-C30 alkyl, linear or branched, and n is an integer from 1 to 200, hydrolyzing the product with water or an aqueous alkaline solution, and subsequent to hydrolysis adding further free-radical initiator.

Abstract: A process for pretreating cellulosic textile, which comprises the steps of: (a) treating cellulosic textile with a solution of polymer or copolymer obtainable by (a1) polymerization or copolymerization of N-vinylamide of the general formula I where R is selected from hydrogen and C1-C10-alkyl, and (a2) partial hydrolysis if appropriate, (b) optionally drying the treated textile, and (c) optionally saponifying all or some of the amide groups, wherein at least one of the steps (a2) and (c) is carried out.

Abstract: The invention relates to copolymers which can be obtained by radical polymerisation of (A) at least one monoethylenically unsaturated C4-C8 dicarboxylic acid anhydride, (B) at least one vinylaromatic compound from the group containing styrol and substituted styrols, and (C) at least one monoethylenically unsaturated monomer which contains at least one heteroatom and is different from (A); by partial esterification of the obtained copolymers with (D) alcohol alkoxylates of formula (I) wherein the variables have the following designations: R represents C2-C6 alkylene radicals which can be the same or different for n>1, R1 represents C1-C30 alkyl, and n represents a number between 1 and 200; and as desired, by hydrolysis of the anhydride groups still contained in the copolymers in order to form carboxyl groups. The invention also relates to the use of said copolymers as additives for washing and cleaning products.

Abstract: The invention relates to acrylate polymers comprising a K-value ranging from 10 to 60, which can be obtained by the radical polymerization of: 30 to 99 wt. % of tert-butyl acrylate and/or tert-butyl methacrylate designated as monomer A; 1 to 28 wt. % of acrylic acid and/or methacrylic acid designated as monomer B, and; 0 to 60 wt. % of a radically copolymerizable monomer or of a radically copolymerizable monomer mixture designated as monomer C, whereby at least one of monomers C yields a homopolymer with a glass-transition temperature lower than 30° C., with the provision that the wt. %'s total 100. The radical polymerization is carried out in the presence of alkane thiols with a C chain length of C 14 to C 22. The invention also relates to acrylate polymers comprising a K-value ranging from 10 to 60, which can be obtained by the radical polymerization of: 30 to 99 wt. % of tert-butyl acrylate and/or tert-butyl methacrylate designated as monomer A; 1 to 28 wt.

Abstract: The present invention relates to cosmetic preparations, in particular for hair cosmetic applications, which comprise copolymers based on N-vinyllactams and N-vinyl heterocyclic compounds.

Abstract: The present invention relates to the use of copolymers A containing a) from 50 to 99% by weight of at least one N-vinyllactam or N-vinylamine selected from the group consisting of N-vinylpyrrolidone, N-vinylpiperidone, N-vinylcaprolactam, N-vinylimidazole, methylated N-vinylimidazole, and N-vinylformamide, and b) from 1 to 50% by weight of at least one monomer selected from the group consisting of b1) C8-C30-alkyl esters of monoethylenically unsaturated C3-C8 carboxylic acids; b2) N—C8-C30-alkyl-substituted amides of monoethylenically unsaturated C3-C8 carboxylic acids; b3) N,N—C8-C30-dialkyl-substituted amides of monoethylenically unsaturated C3-C8 carboxylic acids; b4) vinyl esters of aliphatic C8-C30 carboxylic acids; and b5) C8-C30-alkyl vinyl ethers to produce membranes.

Abstract: The invention relates to the use of graft copolymers obtained by radical graft copolymerisation of a) at least one open-chained N-vinylamide compound of general formula (I) wherein R1, R2, R3 represents H or C1-C6-alkyl and b) optionally, one or several other copolymerizeable monomers on a polymer graft base c) for cosmetic applications, with the proviso that if the polymer graft base is a compound containing polyether, the copolymerizeable polymer b) does not represent vinylester

Abstract: Water-soluble or water-dispersible, film-forming graft copolymers obtainable by free-radical polymerization of

Abstract: A process for wrinkleproofing cellulosic textiles comprises treating the textiles with a finish and drying the treated textiles, wherein the finish contains one or more water soluble or water dispersible polysiloxane-containing polymers obtainable by free radical polymerization of

Abstract: The invention relates to acrylate polymers comprising a K-value ranging from 10 to 60, which can be obtained by the radical polymerization of: 30 to 99 wt. % of tert-butyl acrylate and/or tert-butyl methacrylate designated as monomer A; 1 to 28 wt. % of acrylic acid and/or methacrylic acid designated as monomer B, and; 0 to 60 wt. % of a radically copolymerizable monomer or of a radically copolymerizable monomer mixture designated as monomer C, whereby at least one of monomers C yields a homopolymer with a glass-transition temperature lower than 30° C., with the provision that the wt. %'s total 100. The radical polymerization is carried out in the presence of alkane thiols with a C chain length of C 14 to C 22. The invention also relates to acrylate polymers comprising a K-value ranging from 10 to 60, which can be obtained by the radical polymerization of: 30 to 99 wt. % of tert-butyl acrylate and/or tert-butyl methacrylate designated as monomer A; 1 to 28 wt.

Abstract: The invention relates to the use of graft copolymers obtained by radical graft copolymerisation of a) at least one open-chained N-vinylamide compound of general formula (I) wherein R1, R2, R3 represents H or C1-C6-alkyl and b) optionally, one or several other copolymerizeable monomers on a polymergraft base c) for cosmetic applications, with the proviso that if the polymer graft base is compound containing polyether, the copolymerizeable polymer b) does not represent vinylester.

Abstract: Preparations in powder form comprising or consisting of soluble or insoluble polyvinylpyrrolidone and/or polyvinylpyrrolidone copolymers and suitable as aid for pharmaceutical formulations comprise in homogeneous dispersion very small amounts of heavy metals which are physiologically tolerated in these amounts, or very small amounts of peroxide-cleaving enzymes.