Abstract: The present disclosure belongs to the technical field of biology, and in particular relates to an attenuated strain of African swine fever virus (ASFV) with IPTG-induced deletion of a D1133L gene and use thereof. In the present disclosure, it is firstly found that the D1133L protein of ASFV can inhibit production of IFN-? and downstream cytokines ISG-15 and ISG-56, and can be used as an immunosuppressant with a relatively strong immunosuppressive effect. In addition, the attenuated strain of ASFV with IPTG-induced deletion of the D1133L gene is constructed. Specifically, a screening expression cassette is inserted into a position before the non-structural protein gene D1133L of the ASFV using an Escherichia coli lac operator-repressor system, to obtain a recombinant virus. In the presence of the IPTG, the recombinant virus has similar characteristics to a wild-type virus; and in the absence of the IPTG, the expression of the D1133L protein is inhibited.

Abstract: The present invention relates to the field of coal mine underground auxiliary transportation equipment, and particularly relates to an overhead monorail driving unit group realizing mechanical fast power distribution. The overhead monorail driving unit group realizing mechanical fast power distribution includes a rail, wherein the rail is connected with driving portions, carrying trolleys and a hoisting beam, the hoisting beam is disposed in a middle position of the driving portions and the carrying trolleys, and the driving portions, the carrying trolleys and the hoisting beam are connected through driving portion short pull rods, frame-shaped pull rods and driving portion long pull rods.

Abstract: A substituted heterocyclic fused cyclic compound as represented by formula (I) or formula (IA) and having a selective inhibitory effect on KRAS gene mutation, or a pharmaceutically-acceptable salt, a stereoisomer, a solvate or a prodrug thereof, a pharmaceutical composition containing the compound, and an application thereof in preparation of cancer drugs are provided.

Abstract: The present disclosure provides a positioning tool, a robotic arm system, and a surgical system. The positioning tool includes a body, a registration tip, and a trackable element. The body is used to connect with a terminal of a robotic arm at one end and connect to the registration tip at the other end. The registration tip is used to abut a predetermined position. The trackable element is to be disposed on the body, the registration tip or the robotic arm and is used to communicate with a navigation device. The positioning tool provided in present disclosure is an integrated registration tool, which is able to be used to accomplish registrations for both the robotic arm and the object without replacements of the registration tool during the entire registration process, thereby simplifing the operation and shortening the operation time.

Abstract: An antibody production process in mammalian cells in which engineered unpaired cysteine residues are post-translationally modified and capped with particular chemical entities, which capped antibodies are well suited to further site-specific conjugation steps to form antibody-drug conjugates (ADCs) or protein drug conjugates; ADCs produced using these capped antibodies including in particular ADCs formed by the selective reduction of the capped antibodies' cysteine residues, and ADCs formed using chemical handles such as aldehyde/azide/alkyne biorthogonal groups, which permit additional drug conjugation chemistry; and uncapped antibodies produced by cells in low cysteine, cysteine and glutathione media, and ADCs produced via direct conjugation to these uncapped antibodies.

Abstract: A lithium-ion battery electrode includes a current collector and n electrode plate layers laminated on the current collector, n being an integer greater than or equal to 2. The electrode plate layer contains a pore-forming agent. A content of the pore-forming agent in the electrode plate layers gradually increases along a direction gradually away from the current collector. The pore-forming agent is selected from an electrolyte solution additive which is solid at normal temperature.

Abstract: A method and a system for positron emission tomography (PET) imaging may be provided. Scan data of an object in a first time period of a PET scan of the object may be obtained. A reference image of the object may be also obtained. The reference image may be reconstructed based on reference scan data in a second time period of the PET scan. A target image of the object in the first time period may be generated using an image reconstruction model based on the scan data in the first time period and the reference image of the object.

Abstract: The present disclosure provides a pulse current assisted uncanned rolling method for titanium-TiAl composite plates, including the following specific steps: 1. preparing titanium alloy sheets; 2. preparing TiAl alloy sheets; 3. uncanned lay-up; 4. pulse current assisted hot-rolling; 5. separation and subsequent processing, thus getting the titanium-TiAl composite plates. The composite plates are of good quality on the surface without oxide layer shedding, no cracks at the edges and the ends, with uniform and fine microstructures, good bonding interface and excellent mechanical properties.

Abstract: The present disclosure provides a coal bump control method for sectional hydraulic fracturing regions of a near vertical ultra thick coal seam. The method includes: deepening a main shaft from a mining level to a fracturing level; excavating a cross-hole from a roof rock layer of a coal seam at the fracturing level to enter a coal seam being mined, and excavating a roadway along the strike of the coal seam; and drilling hydraulic fracturing boreholes in a dedicated fracturing roadway along an inclination angle of the coal seam to the coal seam above the roadway, wherein the length of the borehole makes the borehole in communication with a goaf, and the spacing of the boreholes along the strike and the sectional spacing of the boreholes in an inclination direction are designed according to the parameters of fracturing equipments and the fracturing length.

Abstract: The present disclosure discloses a method and apparatus for generating an image. A specific embodiment of the method comprises: acquiring at least two frames of facial images extracted from a target video; and inputting the at least two frames of facial images into a pre-trained generative model to generate a single facial image. The generative model updates a model parameter using a loss function in a training process, and the loss function is determined based on a probability of the single facial generative image being a real facial image and a similarity between the single facial generative image and a standard facial image. According to this embodiment, authenticity of the single facial image generated by the generative model may be enhanced, and then a quality of a facial image obtained based on the video is improved.

Abstract: A coil module includes a first planar coil winding that includes a plurality of turns of coils, at least one turn of first coil in the plurality of turns of coils includes at least one first cutting opening, and the first cutting opening divides the first coil into a first outer side part and a first inner side part along an extension direction of the coil, and a first target side part includes a first cutting groove, the first target side part is at least one of the first outer side part and the first inner side part, an extension direction of the first cutting groove is the same as an extension direction of the first target side part, and a width of a single first cutting groove is less than or equal to a width of a single first cutting opening.

Abstract: Systems and methods for image reconstruction are provided. A method may include obtaining image data that includes information of a plurality of coincidence events; for each of the plurality of coincidence events, identifying, based on the information of the coincidence event, identities of two original scintillator elements at each of which a photon of the coincidence event was detected; obtaining a depth of interaction (DOI) of each photon of the coincidence event within one original scintillator element of the two original scintillator elements; and determining, based on the identities and the DOIs of the two original scintillator elements, identities of two corrected scintillator elements each of which corresponds to an original scintillator element of the two original scintillator elements; and generating a reconstructed image based on the identities of two corrected scintillator elements of each of the plurality of coincidence events.

Abstract: This application provides an electrode assembly, a battery cell, a battery, and an electric apparatus, and pertains to the field of battery technologies. The electrode assembly may include a negative electrode plate and a positive electrode plate. The negative electrode plate may include a negative electrode active substance layer, and a first electrolyte storage trough may be disposed on the negative electrode active substance layer. The positive electrode plate may include a positive electrode active substance layer, the positive electrode active substance layer and the negative electrode active substance layer may be disposed opposite each other in a first direction, and a second electrolyte storage trough may be disposed on the positive electrode active substance layer, the second electrolyte storage trough and the first electrolyte storage trough being disposed opposite each other in the first direction.

Abstract: A method for allocating resource and accessing in open wireless channels includes: covering multiple types of user terminal stations in open wireless channels; making dynamic adaptive matching according to comprehensive change factors of a transmitting end and a receiving end in each communication process. The factors of the transmitting end mean that a type and transmitting capacity of a transmitting station are changed, a current state of the wireless channel between the transmitting station and a relay node is changed, a working state of a receiving end of the relay node is changed, and user services to be transmitted are changed; the factors of the receiving end mean that a type and receiving capacity of a receiving station are changed, a current state of the channel from the relay node to the receiving station is changed, and a working state of a transmitting end of the relay node is changed.

Abstract: The present invention belongs to the technical field of control for rolling mill vibration, and particularly relates to a control device, system and method for vertical-horizontal coupling vibration of a corrugated rolling mill. The control device includes a housing; a vibration-absorbing container is arranged in the housing; a steel ball particle group is placed in the vibration-absorbing container; a left side of the vibration-absorbing container is connected with one end of a return spring; the other end of the return spring is fixedly connected with a third base; the third base is fixedly mounted on a third sliding block; and the third sliding block is slidably arranged on a third linear guide rail.

Abstract: Provided is a method and device for low-carbon integrated energy system scheduling. A specific embodiment of this method comprise: obtaining the energy device information set for each energy device in the virtual power plant; generating the acquisition cost information for each energy device based on an energy device name, energy device parameter information and an energy device number in the energy device information set; generating the energy scheduling objective values and the parameter information of each energy device based on the preset constraint sets and energy acquisition cost information of each energy device; controlling each energy device in the virtual power plant to execute the energy scheduling tasks based on the objective energy device parameter information.

Abstract: The present application discloses a DQN-based distributed computing network coordinate flow scheduling system and method.

Abstract: The present application discloses a timing controller, a polarity grayscale compensation method, and a display panel. The timing controller includes a viewing angle compensation module, an overdriving module, a lookup module, and a compensation module. A corresponding grayscale compensation table is looked up according to a comparison result of a previous frame image data and a current frame image data, a grayscale compensation is performed on the current frame image data after overdriving processing to generate a data signal after grayscale compensation, which can decrease occurrences of bright and dark lines when time-domain viewing angle compensation is switched between frames.

Abstract: Aspects described herein relate to receiving, by a base station, assistance information to facilitate configuring one or more parameters for communicating by a device with the base station, transmitting, by the base station, a signal that does not include the one or more parameters that are based on the assistance information, detecting, by the base station, a degraded feedback for the signal transmitted to the device, and transmitting, by the base station and based on detecting the degraded feedback, an assistance response signal including one or more parameters based on the assistance information.