Abstract: An audio system including an optical microphone and an audio controller. The optical microphone includes a light source and a detector. In some embodiments, the light source illuminates skin of a user. Alternatively the optical microphone also includes a membrane, and the light source illuminates a portion of the membrane. Sounds from a local area cause vibrations in the skin (or vibrations in the membrane). The detector may be in an interferometric configuration or a non-interferometric configuration with the light source. The audio controller monitors the vibrations of the skin (or membrane) using signal output from the detector, and measures the sounds using the monitored vibrations.

Abstract: Provided are a self-nanoemulsifying 3D printer ink composition and a method of using such composition to manufacture a 3D-printed tablet having compartmentalized active pharmaceutical ingredients. In particular, the 3D-printed tablet composition includes glimepiride and/or rosuvastatin in a curcuma oil based self-nanoemulsifying drug delivery system (SNEDDS). The disclosure also provides a method of treating a metabolic disorder or disease by administering a therapeutically effective amount of the 3D-printed tablet to a subject in need thereof.

Abstract: An ophthalmic formulation comprising transethosomes is provided. The transethosomes include a phospholipid, an edge activator, ethanol, and ketoconazole, wherein a surface of the transethosome is modified with a cationic charge inducing agent. The transethosomes may be incorporated into in situ gelling or hydrogel compositions. The formulations are useful for the sustained delivery of ketoconazole to the posterior eye segment of a subject.

Abstract: Provided are a self-nanoemulsifying 3D printer ink composition and a method of using such composition to manufacture a 3D-printed tablet having compartmentalized active pharmaceutical ingredients. In particular, the 3D-printed tablet composition includes glimepiride and/or rosuvastatin in a curcuma oil based self-nanoemulsifying drug delivery system (SNEDDS).

Abstract: Chitosan-coated, flexible lipid-based nanoparticles are provided. The nanoparticles (“chitoplexes”) comprise an interior comprising a mixture of a phospholipid, an edge activator, a charge inducing agent, and a statin; and an exterior chitosan coating which encapsulates the interior mixture. The chitoplexes exhibit enhanced bioavailability with respect to delivering the statins encapsulated therein to a subject, for example, for the treatment of cancer.

Abstract: Provided are an apparatus, memory device, and method for using variable voltages to discharge electrons from a memory array during verify recovery operations. In response to verifying voltages in memory cells of the non-volatile memory array programmed during a programming pulse applying charges to the storage cells, a memory controller concurrently applies voltages on wordlines of the non-volatile memory array to clear the non-volatile memory array of electrons and applies voltages to the bitlines to perform bitline stabilization.

Abstract: Techniques and mechanisms for verifying the programming of a multi-bit cell of a memory array. In an embodiment, program verification is performed based on a signal, other than a word line voltage, which includes an indication of a reference voltage that is to be a basis for evaluating a currently programmed threshold voltage of a memory cell. A determination that the particular indication is to be communicated with the signal is made based on a detected state of the memory device which includes the memory cell. In another embodiment, the detected state includes one of a thermal condition at the memory array, a pressure condition at the memory array, a wear condition of the memory array, or a relative position of the cell with respect to one or more other cells of the memory array.

Abstract: Techniques and mechanisms for verifying the programming of a multi-bit cell of a memory array. In an embodiment, program verification is performed based on a signal, other than a word line voltage, which includes an indication of a reference voltage that is to be a basis for evaluating a currently programmed threshold voltage of a memory cell. A determination that the particular indication is to be communicated with the signal is made based on a detected state of the memory device which includes the memory cell. In another embodiment, the detected state includes one of a thermal condition at the memory array, a pressure condition at the memory array, a wear condition of the memory array, or a relative position of the cell with respect to one or more other cells of the memory array.

Abstract: Provided are an apparatus, memory device, and method for using variable voltages to discharge electrons from a memory array during verify recovery operations. In response to verifying voltages in memory cells of the non-volatile memory array programmed during a programming pulse applying charges to the storage cells, a memory controller concurrently applies voltages on wordlines of the non-volatile memory array to clear the non-volatile memory array of electrons and applies voltages to the bitlines to perform bitline stabilization.

Abstract: An apparatus is described. The apparatus includes a storage device controller having logic circuitry to apply a program voltage verification process for a first threshold level to a group of non volatile memory cells and correlate first program voltages for the group of non volatile memory cells determined from the process to a second threshold level to determine second program voltages for the second threshold level for the group of non volatile memory cells. The second threshold level is higher than the first threshold level.

Abstract: An apparatus is described. The apparatus includes a storage device controller having logic circuitry to apply a program voltage verification process for a first threshold level to a group of non volatile memory cells and correlate first program voltages for the group of non volatile memory cells determined from the process to a second threshold level to determine second program voltages for the second threshold level for the group of non volatile memory cells. The second threshold level is higher than the first threshold level.

Abstract: An in situ gel formulation comprising poly lactide-co-?-caprolactone (PLCL), a surfactant with a hydrophilic-lipophilic balance value of 14-15, a plasticizer, and a statin is provided. Methods of treating hyperlipidemia by parenterally administering the in situ gel formulation are also provided.

Abstract: Micelle formulations comprising a tocopherol or derivative thereof, alpha lipoic acid, and a biologically active agent such as vinpocetine are provided. Films for transdermal delivery containing the micelle formulation and methods of treating cognitive and cerebrovascular disorders are also provided.

Abstract: The invention provides a compound of formula (Ia) or (Ib): or a salt thereof, wherein A, B, C, D, E, F, J, K, L, M, Q, V, X, Y, W and Z have any of the values described in the specification, as well as compositions comprising a compound of formula (Ia) or (Ib) or a salt thereof, and methods of use thereof.

Abstract: An improved endoscopic device for obtaining 3-dimensional human vision simulated imaging with real dynamic convergence in therapeutic, diagnostic, and other applications. Imaging probes are mounted on a tubular shaft and a simple/sleek slider moves back-and-forth on the shaft, with slider movement optionally modified and redirected to affect imaging probe convergence/divergence. Imaging probe convergence/divergence can be optionally manual for visual target selection, and the probe arms upon which the imaging probes are mounted may also be moved through a combined 180 degree movement range using a manual control. The first and second movement transmitting means respectively adapted to cause slider-initiated convergence, or manual convergence, of the imaging probes each share at least one integrated movement element with the control means adapted for engaging and disengaging the first and second movement transmitting means.

Abstract: Methods of enhancing cognition and/or memory and methods of treating cognitive and cerebrovascular disorders by intranasally administering an in situ gelling composition comprising micelles formed with tocopherol or a derivative thereof are provided. The micelles encapsulate a biological active agent such as vinpocetine. The methods provide for enhanced brain targeting of the biological active agent.

Abstract: Mucoadhesive buccal films comprising a statin-hydroxypropyl-beta-cyclodextrin inclusion complex and a statin-loaded mixed micelle composition, wherein the ratio of the mixed micelle composition to the inclusion complex is from 2:0.5 to 2:1.5 are provided. Methods of improving permeation of a statin across mucosal tissue by administering the film to a subject are also provided.

Abstract: Solid dosage pullulan-based buccal tablets containing a polyvinyl pyrrolidone and vinpocetine (e.g., lyophilized polyvinyl pyrrolidone vinyl acetate and vinpocetine), when administered via the buccal mucosa, provide increased bioavailability of the active agent. The formulations may be used to treat a variety of indications for which vinpocetine has been shown to have beneficial activity, and have particular utility in the treatment of cerebral degenerative diseases.

Abstract: A device for facilitating a total laparoscopic hysterectomy includes a cervical cup adapted to abut the cervicovaginal junction. An electrocautery wire has an uninsulated portion housed in the cervical cup which includes a channel for housing and controlled releasing the uninsulated portion. An introducer is coupled to the electrocautery wire and configured to penetrate the cervicovaginal junction thereby introducing the electrocautery wire into the intra-abdominal cavity. A shaft secures the electrocautery wire and pulling the electrocautery wire causes a controlled release of the uninsulated portion along a predetermined circumferential path around the cervix along the channel. Thus, the vagina is severed from the cervix along the circumference of the cervicovaginal junction.

Abstract: An improved endoscopic device for obtaining 3-dimensional human vision simulated imaging with real dynamic convergence in therapeutic, diagnostic, and other applications. Imaging probes are mounted on a tubular shaft and a simple/sleek slider moves back-and-forth on the shaft, with slider movement optionally modified and redirected to affect imaging probe convergence/divergence. Imaging probe convergence/divergence can be optionally manual for visual target selection, and the probe arms upon which the imaging probes are mounted may also be moved through a combined 180 degree movement range using a manual control. The first and second movement transmitting means respectively adapted to cause slider-initiated convergence, or manual convergence, of the imaging probes each share at least one integrated movement element with the control means adapted for engaging and disengaging the first and second movement transmitting means.