Patents by Inventor Tarek Mansour

Tarek Mansour has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration
    Publication number: 20020058670
    Abstract: The present invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about −10° C.
    Type: Application
    Filed: November 16, 2001
    Publication date: May 16, 2002
    Applicant: BIOCHEM PHARMA INC.
    Inventors: Tarek Mansour, Alex Cimpoia, Krzysztof Bednarski
  • Processes for preparing substituted 1, 3-oxathiolanes with antiviral properties
    Publication number: 20010041797
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: 1
    Type: Application
    Filed: January 16, 2001
    Publication date: November 15, 2001
    Applicant: BioChem Pharma Inc.
    Inventors: Bernard Belleau, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 6175008
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S═O or SO2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 16, 2001
    Assignee: BioChem Pharma Inc.
    Inventors: Bernard Belleau, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • Use of dideoxy nucleoside analogues in the treatment of viral infections
    Patent number: 6156737
    Abstract: The present invention is directed to a method of treating hepatitis B viral infections in mammals comprising the administration of .beta.-L-5-fluoro-2',3'-dideoxycytidine and pharmaceutically acceptable derivatives thereof.
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: December 5, 2000
    Assignee: BioChem Pharma Inc.
    Inventors: Tarek Mansour, Allan H.L. Tse
  • Method and compositions for the synthesis of dioxolane nucleosides with .beta.-configuration
    Patent number: 6069250
    Abstract: The present invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about -10.degree. C. ##STR1## wherein R.sub.1 and L are as defined herein.
    Type: Grant
    Filed: February 17, 1999
    Date of Patent: May 30, 2000
    Assignee: Biochem Pharma Inc.
    Inventors: Tarek Mansour, Alex Cimpoia, Krzysztof Bednarski
  • Method and compositions for the synthesis of dioxolane nucleosides with .beta. configuration
    Patent number: 5922867
    Abstract: The present invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. In particular, this invention relates to the stereoselective synthesis of the beta (cis) isomer by glycosylating the base with an intermediate of formula (II) below a temperature of about -10.degree. C. ##STR1## wherein R.sub.1 and L are defined herein.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: July 13, 1999
    Assignee: Biochem Pharma Inc.
    Inventors: Tarek Mansour, Alex Cimpoia, Krzysztof Bednarski
  • Processes for the diastereoselective synthesis of nucleoside analogues
    Patent number: 5756706
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity, and intermediates useful in those processes.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: May 26, 1998
    Assignee: BioChem Pharma Inc.
    Inventors: Tarek Mansour, Allan H. L. Tse
  • Nucleoside analogues and synthetic intermediates
    Patent number: 5744596
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 28, 1998
    Assignee: Biochem Pharma Inc.
    Inventors: Tarek Mansour, Allan H. L. Tse
  • Processes for the diastereoselective synthesis of nucleoside analogues
    Patent number: 5696254
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity, and intermediates useful in those processes.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: December 9, 1997
    Assignee: BioChem Pharma Inc.
    Inventors: Tarek Mansour, Haolun Jin, Allan H. L. Tse, M. Arshad Siddiqui
  • Intermediates in the synthesis of 1,3-oxathiolanyl cytosine nucleoside analogues
    Patent number: 5693787
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 2, 1997
    Assignee: BioChem Pharma Inc.
    Inventors: Tarek Mansour, Haolun Jin, Allan H. L. Tse, M. Arshad Siddiqui
  • Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 5684164
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 4, 1997
    Assignee: BioChem Pharma Inc.
    Inventors: Bernard Belleau, deceased, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • Processes for the diastereoselective separation of nucleoside analogue synthetic intermediates
    Patent number: 5663320
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 2, 1997
    Assignee: BioChem Pharma, Inc.
    Inventors: Tarek Mansour, Haolun Jin, Allan H.L. Tse, M. Arshad Siddiqui
  • Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
    Patent number: 5587480
    Abstract: This invention relates to novel substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes or pharmaceutically acceptable salts and esters thereof, of the formula: ##STR1## wherein X is S, S.dbd.O, or SO.sub.2 ;Y is O, S, S.dbd.O, or SO.sub.2 ;R.sub.1 is hydrogen, trisubstituted silyl, C.sub.1-6 alkyl, aralkyl, or C.sub.1-6 acyl, and R.sub.2 is a pyrimidine base or an analogue or derivative thereof.This invention also relates to processes for preparing these compounds, intermediates useful in their preparation, to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: December 24, 1996
    Assignee: BioChem Pharma, Inc.
    Inventors: Bernard Belleau, deceased, Nghe Nguyen-Ba, Laval C. C. Kong, Tarek Mansour, Haolun Jin, Livio Brasili
  • Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 5466806
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: November 14, 1995
    Assignee: Biochem Pharma Inc.
    Inventors: Bernard Belleau, deceased, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba