Abstract: Compositions, systems and methods are provided for the treatment of subcutaneous brown or beige fat or visceral brown or beige fat, wherein the compositions comprise a cold solution comprising liquid water and/or ice particles, and optionally one or more additives and/or pharmacologic agents. The treatment of subcutaneous or visceral brown or beige fat provides activation of brown adipocytes, proliferation of brown adipocytes, increased volume of brown adipocytes, differentiation of precursors into beige and/or brown adipocytes, activation of beige adipocytes, stimulation of beige adipocytes and/or cryolipolysis of white adipocytes. The methods of treatment result in increased metabolic health, weight loss, and improved health.

Abstract: The present invention provides a cold solution and method for treating obstructive sleep apnea. The cold solution can comprise liquid and/or solid ice particles. In one embodiment, the method comprises delivering a cold solution to target tissue where the target tissue can be fat tissue located in one or more of an airway, a neck, a thorax, a diaphragm, a face, or an abdomen.

Abstract: A substantially solid solution is provided, which includes water and optionally one or more additives, wherein about 71% to about 100% of the water by volume is in a solid state. The substantially solid solution may be administered to a subcutaneous fat layer of a subject, in order to reduce or remove adipocytes through freezing. The substantially solid solution may be generated in a mold, or at a point of delivery, and may be administered by any suitable device or administered directly to a treatment site via an incision.

Abstract: The present invention provides a cold solution and method for inducing therapeutic hypothermia. The cold solution can comprise liquid and/or solid ice particles.