Patents by Inventor Tatsuhiro Kobashi

Tatsuhiro Kobashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9610369
    Abstract: The present invention provides a compound represented by formula (I), wherein in formula (I), R1 represents CH3, F, (CH2)n—F, NH—(CH2)n—F, O—(CH2)n—F or S—(CH2)n—F, and n represents an integer of 1 to 3.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: April 4, 2017
    Assignees: HAMAMATSU PHOTONICS K.K., NARD INSTITUTE, LTD.
    Inventors: Hideo Tsukada, Shingo Nishiyama, Takeru Kitashoji, Tatsuhiro Kobashi, Yumi Nakamasu, Hidekazu Nakao
  • Publication number: 20160051711
    Abstract: The present invention provides a compound represented by formula (I), wherein in formula (I), R1 represents CH3, F, (CH2)n—F, NH—(CH2)n—F, O—(CH2)n—F or S—(CH2)n—F, and n represents an integer of 1 to 3.
    Type: Application
    Filed: April 2, 2014
    Publication date: February 25, 2016
    Inventors: Hideo TSUKADA, Shingo NISHIYAMA, Takeru KITASHOJI, Tatsuhiro KOBASHI, Yumi NAKAMASU, Hidekazu NAKAO
  • Patent number: 7901559
    Abstract: It is intended to provide a method for easily detecting a phosphorylated peptide (protein) in a test sample by using SDS-polyacrylamide gel electrophoresis (SDS-PAGE) which has been conventionally employed in analyzing a protein; a polyacrylamide gel for electrophoresis to be used in the method; a method of producing the gel; and a synthesizing intermediate in producing the gel. The polyacrylamide gel for electrophoresis to be used in the method of the invention is characterized in that at least a part of the structure thereof has a structure represented by the following formula (I); wherein M2+represents a transition metal ion; and X represents a linker group.
    Type: Grant
    Filed: August 1, 2005
    Date of Patent: March 8, 2011
    Assignee: Nard Institute, Ltd.
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi
  • Patent number: 7804592
    Abstract: The present invention provides a method for measuring a surface plasmon resonance, the method enabling easy detection of the existence of a phosphorylated peptide (protein) and determination whether a peptide is phosphorylated or not in biological materials. The present invention also provides a noble metal compound having high capability of coordination to a phosphorylated peptide, and being conveniently usable in the method. A first method for measuring surface plasmon resonance of the present invention comprises: placing a noble metal compound on a bottom face of a prism, irradiating a light to the prism to detect a reflected light, wherein, the noble metal compound has substituents of following formula (I) on a side opposite to a side contacting the prism, and a subject sample is added to a side having the substituent groups (I) in the noble metal compound.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: September 28, 2010
    Assignee: NARD Institute, Ltd.
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi, Makoto Takahagi
  • Publication number: 20100108515
    Abstract: It is intended to provide a method for easily detecting a phosphopeptide (protein) in a test sample by using SDS-poly-acrylamide gel electrophoresis (SDS-PAGE) which has been employed in analyzing a protein, a polyacrylamide gel for electrophoresis to be used in the above method, a method of producing the gel and an intermediate in synthesizing the gel. The polyacrylamide gel for electrophoresis to be used in the above method has a structure represented by the following general formula (I) in at least a part of the structure thereof: (I) wherein M2+ represents a transition metal ion; and X represents a linker.
    Type: Application
    Filed: August 1, 2005
    Publication date: May 6, 2010
    Applicant: NARD INSTITUTE, LTD.
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi
  • Publication number: 20090185181
    Abstract: The present invention provides a method for measuring a surface plasmon resonance, the method enabling easy detection of the existence of a phosphorylated peptide (protein) and determination whether a peptide is phosphorylated or not in biological materials. The present invention also provides a noble metal compound having high capability of coordination to a phosphorylated peptide, and being conveniently usable in the method. A first method for measuring surface plasmon resonance of the present invention comprises: placing a noble metal compound on a bottom face of a prism, irradiating a light to the prism to detect a reflected light, wherein, the noble metal compound has substituents of following formula (I) on a side opposite to a side contacting the prism, and a subject sample is added to a side having the substituent groups (I) in the noble metal compound.
    Type: Application
    Filed: October 12, 2004
    Publication date: July 23, 2009
    Applicant: Kabushiki Kaisha Nard Kenkyusho
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi, Makoto Takahagi
  • Publication number: 20090087378
    Abstract: It is an objective of the present invention to provide a positron tomography method applicable to the diagnosis of specific brain diseases and to provide a positron-emitting compound for use in the method. The present invention method relates to a positron tomography method for measuring a distribution and concentration of a positron-emitting source, and is characterized in using the compound (I) as the positron-emitting source.
    Type: Application
    Filed: February 16, 2007
    Publication date: April 2, 2009
    Applicant: NARD INSTITUTE, LTD.
    Inventors: Masaaki Matsuo, Takeru Kitashoji, Tatsuhiro Kobashi, Makoto Takahagi, Hideo Tsukada, Shingo Nishiyama
  • Patent number: 7202093
    Abstract: Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylated peptides and usable in the methods. The complex compound is represented by the formula: wherein X is a linker moiety, and Y is a labeling group. The compound (I) is highly coordinated to a phosphorylated peptide, and has a labeling group. Accordingly, with use of the compound (I), the phosphorylated peptide can be easily identified.
    Type: Grant
    Filed: February 23, 2004
    Date of Patent: April 10, 2007
    Assignee: Kabushiki Kaisha Nard Kenkyusho
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi, Makoto Takahagi
  • Publication number: 20040198712
    Abstract: Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylated peptides and usable in the methods.
    Type: Application
    Filed: February 23, 2004
    Publication date: October 7, 2004
    Applicant: Kabushiki Kaisha Nard Kenkyusho
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi, Makoto Takahagi