Abstract: Cyclized peptides having a crosslinked structure by one or more intramolecular S—S bonds may be prepared by: (1-A) as to a completely protected linear peptide having two or more SH groups as functional groups on the peptide, removing protecting groups of all functional groups other than the protected SH groups in the peptide, (1-B) protecting all SH groups of the linear peptide having two or more SH groups as the functional groups on the peptide by forming a temporary S—S bond, and (2) subjecting the peptide obtained by step (1-A) and step (1-B) to a folding step under oxidation and reduction conditions to obtain the cyclized peptide by re-forming an S—S bond in the peptide molecule.

Abstract: Provided is a composition useful for preventing and/or treating neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. The composition is for preventing and/or treating a neurodegenerative disorder, and contains, as an active ingredient, a compound represented by the following formula (I): or an isomer thereof, or a salt thereof.

Abstract: A gas turbine control device includes a detection value acquisition unit that acquires a detection value of at least one of a supply amount of fuel, pressure of compressed air, and electric power generated by a generator; a flue gas temperature acquisition unit that acquires a flue gas temperature detection value; a combustion gas temperature estimate value calculation unit that calculates a combustion gas temperature estimate value based on the detection value; a correction term acquisition unit that calculates a correction term based on a ratio between the combustion gas temperature estimate value and the flue gas temperature detection value; a corrected combustion gas temperature estimate value calculation unit that corrects the combustion gas temperature estimate value using the correction term to calculate a corrected combustion gas temperature estimate value; and a gas turbine controller that controls the gas turbine based on the corrected combustion gas temperature estimate value.

Abstract: A gas turbine control device includes a detection value acquisition unit that acquires a detection value of at least one of a supply amount of fuel, pressure of compressed air, and electric power generated by a generator; a flue gas temperature acquisition unit that acquires a flue gas temperature detection value; a combustion gas temperature estimate value calculation unit that calculates a combustion gas temperature estimate value based on the detection value; a correction term acquisition unit that calculates a correction term based on a ratio between the combustion gas temperature estimate value and the flue gas temperature detection value; a corrected combustion gas temperature estimate value calculation unit that corrects the combustion gas temperature estimate value using the correction term to calculate a corrected combustion gas temperature estimate value; and a gas turbine controller that controls the gas turbine based on the corrected combustion gas temperature estimate value.

Abstract: A shaft seal structure capable of preventing a seal body of the shaft seal structure of a rotation body from being held in an inclined posture even when the seal body is inclined is provided. It includes, an accommodation body (9), a seal body (12) including thin plate seal pieces (20), and a plate body (17) covering one end in the axial direction (20d) of the seal body (12). A recessed portion (31) recessing in the axis direction, and a protruding portion projecting to the other side from the recessed portion (31) are formed on one of the plate surface (17c) of the plate body (17) and the inner wall surface (9e) of the accommodation body (9). When the protruding portion abuts the other side and a pocket (X), the recessed portion (31) communicates with the pocket (X) and the fluid low pressure region.

Abstract: An inner wall surface of a low-pressure-side side plate opposite to a lateral surface of a thin plate is formed along a direction crossing an axial direction of a rotating shaft such that a gap between the inner wall surface and the thin plate gradually decreases from a radially inner side toward a radially outer side of the low-pressure-side side plate.

Abstract: Provided is a gas turbine plant that enables active clearance control for ensuring tip clearance of first-stage turbine rotor blades required during start-up and for achieving the minimum tip clearance during load operation. In a gas turbine plant including a cooler in an air system used for cooling second-stage turbine stator blades, a first-stage segmented ring and a second-stage segmented ring that oppose tips of first-stage turbine rotor blades and second-stage turbine rotor blades are supported by the same blade ring member, and a cooling-air for the second-stage turbine stator blades forms a cooling air flow cooling the blade ring, to control thermal expansion of the blade ring and to control the clearance with respect to the tips.

Abstract: An inner wall surface of a low-pressure-side side plate opposite to a lateral surface of a thin plats is formed along a direction crossing an axial direction of a rotating shaft such that a gap between the inner wall surface and the thin plate gradually decreases from a radially inner side toward a radially outer side of the low-pressure-side side plate.

Abstract: A shaft seal structure capable of preventing a seal body of the shaft seal structure of a rotation body from being held in an inclined posture even when the seal body is inclined is provided. It includes, an accommodation body (9), a seal body (12) including thin plate seal pieces (20), and a plate body (17) covering one end in the axial direction (20d) of the seal body (12). A recessed portion (31) recessing in the axis direction, and a protruding portion projecting to the other side from the recessed portion (31) are formed on one of the plate surface (17c) of the plate body (17) and the inner wall surface (9e) of the accommodation body (9). When the protruding portion abuts the other side and a pocket (X), the recessed portion (31) communicates with the pocket (X) and the fluid low pressure region.

Abstract: Provided is a gas turbine plant that enables active clearance control for ensuring tip clearance of first-stage turbine rotor blades required during start-up and for achieving the minimum tip clearance during load operation. In a gas turbine plant including a cooler in an air system used for cooling second-stage turbine stator blades, a first-stage segmented ring and a second-stage segmented ring that oppose tips of first-stage turbine rotor blades and second-stage turbine rotor blades are supported by the same blade ring member, and a cooling-air for the second-stage turbine stator blades forms a cooling air flow cooling the blade ring, to control thermal expansion of the blade ring and to control the clearance with respect to the tips.

Abstract: Disclosed is a gas turbine enabling turn down operation, of which the system and the operation can be simplified, and also the production cost and the maintenance cost can be reduced. Specifically disclosed is a gas turbine comprising: a compressor section (2); a combustor section (3); a turbine section (4); a gas turbine casing which houses the compressor section (2), the combustor section (3), and the turbine section (4) therein; a stator cooling air system (5) for leading compressed air extracted from midstream of the compressor section (2) into stator vanes which constitute the turbine section (4); and an air bleeding system (6) for extracting compressed air from the exit of the compressor section (2) to the outside of the gas turbine casing, wherein midstream of the stator cooling air system (5) and midstream of the air bleeding system (6) are connected via a connecting path (12), and at midstream of this connecting path (12), there is a flow rate control part (13) connected.