Patents by Inventor Tatsuo Miyamura
Tatsuo Miyamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8906862Abstract: This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.Type: GrantFiled: August 29, 2011Date of Patent: December 9, 2014Assignees: The Regents of the University of California, National Institute of Infectious Disease, Tsukuba Primate Research Center, National Institue of Biomedical InnovationInventors: R. Holland Cheng, Li Xing, Tatsuo Miyamura, Yasuhiro Yasutomi, Tian-Cheng Li, Naokazu Takeda
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Patent number: 8357792Abstract: A polynucleotide base sequence represented by SEQ ID NO: 22, a vector containing the polynucleotide and a method of preparing a small round structure virus (SRSV) virus-like particle in insect cells with vector.Type: GrantFiled: October 6, 2011Date of Patent: January 22, 2013Assignees: Japan as represented by Director-General National Institute of Infectious Diseases, Denka Seiken Co., Ltd.Inventors: Naokazu Takeda, Katsuro Natori, Tatsuo Miyamura, Kunio Kamata, Toshinori Sato, Seiya Sato
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Publication number: 20120142054Abstract: A polynucleotide base sequence represented by SEQ ID NO: 22, a vector containing the polynucleotide and a method of preparing a small round structure virus (SRSV) virus-like particle in insect cells with vector.Type: ApplicationFiled: October 6, 2011Publication date: June 7, 2012Applicants: DENKA SEIKEN CO. LTD., JP AS REP BY DIR-GEN NATL INST OF INF DISInventors: Naokazu TAKEDA, Katsuro Natori, Tatsuo Miyamura, Kunio Kamata, Toshinori Sato, Seiya Sato
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Patent number: 8183044Abstract: The present invention relates to a method for producing a recombinant hepatitis C virus-like particle comprising the steps of introducing into (i) a cell in which an RNA replicon comprising a nucleotide sequence comprising the 5? untranslated region, the nucleotide sequence coding for the NS3, NS4A, NS4B, NS5A, and NS5B proteins, and the 3? untranslated region of a genome RNA derived from a hepatitis C virus strain autonomously replicates, (ii) a vector expressing the Core, E1, E2, and p7 proteins derived from a hepatitis C virus strain that is the same as or different from that as defined in the above (i), culturing the cell, and recovering the produced virus-like particle, and a recombinant hepatitis C virus particle produced by this method.Type: GrantFiled: September 29, 2006Date of Patent: May 22, 2012Assignees: Japan as represented by Director-General of National Institute of Infectious Diseases, Tokyo Metropolitan Institute of Medical Science, Toray Industries, Inc.Inventors: Jun-ichi Tanabe, Saburo Sone, Takaji Wakita, Koji Ishii, Ryosuke Suzuki, Tetsuro Suzuki, Tatsuo Miyamura
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Patent number: 8143022Abstract: The present invention relates to a method for producing infectious hepatitis C virus (HCV) particles, comprising a step of introducing an expression vector into a cell that allows HCV proliferation, such expression vector comprising: DNA sequences encoding the 5? untranslated region, structural proteins, and, if necessary, non-structural proteins of HCV and DNA sequences encoding non-structural proteins and the 3? untranslated region derived from the HCV JFH1 strain, which are located downstream of a polymerase I promoter; and a DNA fragment containing an RNA polymerase I terminator, which is located further downstream thereof.Type: GrantFiled: September 29, 2006Date of Patent: March 27, 2012Assignee: Tokyo Metropolitan Institute of Medical ScienceInventors: Jun-ichi Tanabe, Saburo Sone, Takaji Wakita, Koji Ishii, Ryosuke Suzuki, Tetsuro Suzuki, Tatsuo Miyamura
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Publication number: 20120064169Abstract: This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.Type: ApplicationFiled: August 29, 2011Publication date: March 15, 2012Applicants: The Regents of the University of California, Tsukuba Primate Research Center, National Institute of Biomedical Innovation, National Institute of Infectious DiseaseInventors: R. Holland Cheng, Li Xing, Tatsuo Miyamura, Yasuhiro Yasutomi, Tian-Cheng Li, Naokazu Takeda
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Patent number: 8067560Abstract: This invention relates to an SRSV detection kit comprising all antibodies against SRSV-related virus constituting peptides selected from the following peptide groups (a) to (k), respectively: (a) a peptide having an amino acid sequence represented by SEQ ID NO: 1, and the like, (b) a peptide having an amino acid sequence represented by SEQ ID NO: 2, and the like, (c) a peptide having an amino acid sequence represented by SEQ ID NO: 3, and the like, (d) a peptide having an amino acid sequence represented by SEQ ID NO: 4, and the like, (e) a peptide having an amino acid sequence represented by SEQ ID NO: 5, and the like, (f) a peptide having an amino acid sequence represented by SEQ ID NO: 6, and the like, (g) a peptide having an amino acid sequence represented by SEQ ID NO: 7, and the like, (h) a peptide having an amino acid sequence represented by SEQ ID NO: 8, and the like, (i) a peptide having an amino acid sequence represented by SEQ ID NO: 9, and the like, (j) a peptide having an amino acid sequence repreType: GrantFiled: July 7, 2009Date of Patent: November 29, 2011Assignees: Japan as represented by Director-General National Institute of Infectious Diseases, Denka Seiken Co., Ltd.Inventors: Naokazu Takeda, Katsuro Natori, Tatsuo Miyamura, Kunio Kamata, Toshinori Sato, Seiya Sato
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Publication number: 20100035345Abstract: The present invention relates to a method for producing infectious hepatitis C virus (HCV) particles, comprising a step of introducing an expression vector into a cell that allows HCV proliferation, such expression vector comprising: DNA sequences encoding the 5? untranslated region, structural proteins, and, if necessary, non-structural proteins of HCV and DNA sequences encoding non-structural proteins and the 3? untranslated region derived from the HCV JFH1 strain, which are located downstream of a polymerase I promoter; and a DNA fragment containing an RNA polymerase I terminator, which is located further downstream thereof.Type: ApplicationFiled: September 29, 2006Publication date: February 11, 2010Inventors: Jun-ichi Tanabe, Saburo Sone, Takaji Wakita, Koji Ishii, Ryosuke Suzuki, Tetsuro Suzuki, Tatsuo Miyamura
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Publication number: 20090305420Abstract: This invention relates to an SRSV detection kit comprising all antibodies against SRSV-related virus constituting peptides selected from the following peptide groups (a) to (k), respectively: (a) a peptide having an amino acid sequence represented by SEQ ID NO: 1, and the like, (b) a peptide having an amino acid sequence represented by SEQ ID NO: 2, and the like, (c) a peptide having an amino acid sequence represented by SEQ ID NO: 3, and the like, (d) a peptide having an amino acid sequence represented by SEQ ID NO: 4, and the like, (e) a peptide having an amino acid sequence represented by SEQ ID NO: 5, and the like, (f) a peptide having an amino acid sequence represented by SEQ ID NO: 6, and the like, (g) a peptide having an amino acid sequence represented by SEQ ID NO: 7, and the like, (h) a peptide having an amino acid sequence represented by SEQ ID NO: 8, and the like, (i) a peptide having an amino acid sequence represented by SEQ ID NO: 9, and the like, (j) a peptide having an amino acid sequence repreType: ApplicationFiled: July 7, 2009Publication date: December 10, 2009Applicants: JP AS REP BY DIR-GEN NATL INST OF INF DIS, DENKA SEIKEN CO., LTD.Inventors: Naokazu TAKEDA, Katsuro Natori, Tatsuo Miyamura, Kunio Kamata, Toshinori Sato, Seiya Sato
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Publication number: 20090221028Abstract: The present invention relates to a method for producing a recombinant hepatitis C virus-like particle comprising the steps of introducing into (i) a cell in which an RNA replicon comprising a nucleotide sequence comprising the 5? untranslated region, the nucleotide sequence coding for the NS3, NS4A, NS4B, NS5A, and NS5B proteins, and the 3? untranslated region of a genome RNA derived from a hepatitis C virus strain autonomously replicates, (ii) a vector expressing the Core, E1, E2, and p7 proteins derived from a hepatitis C virus strain that is the same as or different from that as defined in the above (i), culturing the cell, and recovering the produced virus-like particle, and a recombinant hepatitis C virus particle produced by this method.Type: ApplicationFiled: September 29, 2006Publication date: September 3, 2009Inventors: Jun-ichi Tanabe, Saburo Sone, Takaji Wakita, Koji Ishii, Ryosuke Suzuki, Tetsuro Suzuki, Tatsuo Miyamura
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Patent number: 7575753Abstract: This invention relates to an SRSV detection kit comprising all antibodies against SRSV-related virus constituting peptides selected from the following peptide groups (a) to (k), respectively: (a) a peptide having an amino acid sequence represented by SEQ ID NO: 1, and the like, (b) a peptide having an amino acid sequence represented by SEQ ID NO: 2, and the like, (c) a peptide having an amino acid sequence represented by SEQ ID NO: 3, and the like, (d) a peptide having an amino acid sequence represented by SEQ ID NO: 4, and the like, (e) a peptide having an amino acid sequence represented by SEQ ID NO: 5, and the like, (f) a peptide having an amino acid sequence represented by SEQ ID NO: 6, and the like, (g) a peptide having an amino acid sequence represented by SEQ ID NO: 7, and the like, (h) a peptide having an amino acid sequence represented by SEQ ID NO: 8, and the like, (i) a peptide having an amino acid sequence represented by SEQ ID NO: 9, and the like, (j) a peptide having an amino acid sequence repreType: GrantFiled: April 13, 2006Date of Patent: August 18, 2009Assignees: Japan as Represented by Director-General National Institute of Infectious Diseases, Denka Seiken Co., Ltd.Inventors: Naokazu Takeda, Katsuro Natori, Tatsuo Miyamura, Kunio Kamata, Toshinori Sato, Seiya Sato
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Patent number: 7101551Abstract: The present invention provides a substance which inhibits the binding between E2/NS1 protein of hepatitis C virus and a cell infectious with hepatitis C virus, a cell expressing CD81, or CD81. The present invention can provide a novel medicament which has an anti-viral effects such as an inhibitory action against HCV infection.Type: GrantFiled: February 13, 2001Date of Patent: September 5, 2006Assignees: Mitsubishi Pharma Corporation, Japan as Represented by Director General of Agency of National Institute of Infectious DiseasesInventors: Seima Itami, Tatsurou Shibui, Makoto Seki, Yoshihisa Yotsumoto, Yoshiharu Matsuura, Tatsuo Miyamura
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Publication number: 20060177820Abstract: This invention relates to an SRSV detection kit comprising all antibodies against SRSV-related virus constituting peptides selected from the following peptide groups (a) to (k), respectively: (a) a peptide having an amino acid sequence represented by SEQ ID NO: 1, and the like, (b) a peptide having an amino acid sequence represented by SEQ ID NO: 2, and the like, (c) a peptide having an amino acid sequence represented by SEQ ID NO: 3, and the like, (d) a peptide having an amino acid sequence represented by SEQ ID NO: 4, and the like, (e) a peptide having an amino acid sequence represented by SEQ ID NO: 5, and the like, (f) a peptide having an amino acid sequence represented by SEQ ID NO: 6, and the like, (g) a peptide having an amino acid sequence represented by SEQ ID NO: 7, and the like, (h) a peptide having an amino acid sequence represented by SEQ ID NO: 8, and the like, (i) a peptide having an amino acid sequence represented by SEQ ID NO: 9, and the like, (j) a peptide having an amino acid sequence repreType: ApplicationFiled: April 13, 2006Publication date: August 10, 2006Applicants: JP AS REP BY DIR-GEN NATL INST OF INF DIS, DENKA SEIKEN CO., LTD.Inventors: Naokazu Takeda, Katsuro Natori, Tatsuo Miyamura, Kunio Kamata, Toshinori Sato, Seiya Sato
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Patent number: 7067638Abstract: This invention relates to an SRSV detection kit comprising all antibodies against SRSV-related which makes it possible to detect most SRSV-related viruses and further to distinguish their serotypes and genogroups.Type: GrantFiled: June 22, 2000Date of Patent: June 27, 2006Assignees: Japan as represented by Director-General National Institute of Infectious Diseases, Denka Seiken Co., Ltd.Inventors: Naokazu Takeda, Katsuro Natori, Tatsuo Miyamura, Kunio Kamata, Toshinori Sato, Seiya Sato
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Publication number: 20050053620Abstract: The invention provides a recombinant vaccinia virus strain DIs that possesses a polynucleotide encoding a foreign antigenic protein in the non-essential gene region of the chromosome DNA and expresses the antigenic protein; and provides a highly-safe, vaccinia virus vaccine containing the recombinant virus strain DIs as the active ingredient. The invention also provides a method of using the vaccinia virus strain DIs as a vector for protein expression.Type: ApplicationFiled: November 20, 2001Publication date: March 10, 2005Inventors: Mitsuo Honda, Kazuhiro Matsuo, Takeaki Ohsu, Tatsuo Miyamura, Yoshiharu Matsuura, Koji Ishii, Kenzo Kato
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Publication number: 20030157132Abstract: The present invention provides a substance which inhibits the binding between E2/NS1 protein of hepatitis C virus and a cell infectious with hepatitis C virus, a cell expressing CD81, or CD81. The present invention can provide a novel medicament which has an anti-viral effects such as an inhibitory action against HCV infection.Type: ApplicationFiled: November 26, 2002Publication date: August 21, 2003Inventors: Seima Itami, Tatsurou Shibui, Makoto Seki, Yoshihisa Yotsumoto, Yoshiharu Matsuura, Tatsuo Miyamura
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Patent number: 6063904Abstract: A method for extracellularly producing an ectoprotein of hepatitis C virus comprises the steps of cultivating a transformant which is transformed with an expression vector containing a DNA fragment coding for the ectoprotein of hepatitis C virus and recovering the ectoprotein of hepatitis C virus extracellularly produced by the transformant. The protein originated from the E1 region prepared by the method can be used as a material for preparing a vaccine for preventing HCV infection. In addition, a diagnostic agent containing the protein is useful for the detection of an HCV antibody or the confirmation of the presence thereof in sera or the like. In other words, the protein of the present invention permits the diagnosis of C type hepatitis in high specificity and sensitivity.Type: GrantFiled: August 3, 1998Date of Patent: May 16, 2000Assignee: Japan as represented by the Director General of the Agency of National Institute of HealthInventors: Tatsuo Miyamura, Izumu Saito, Yoshiharu Matsuura, Yoshikazu Honda, Makoto Seki
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Patent number: 5959092Abstract: Two new isolates of the Hepatitis C virus (HCV), J1 and J7, are disclosed. These new isolates comprise nucleotide and amino acid sequences which are distinct from the prototype HCV isolate, HCV1. Thus, J1 and J7 provide new polynucleotides and polypeptides for use, inter alia, in diagnostics, recombinant protein production and vaccine development.Type: GrantFiled: May 8, 1995Date of Patent: September 28, 1999Assignees: Chiron Corporation, The Director General of the National Institute of Health of JapanInventors: Tatsuo Miyamura, Izumi Saito
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Patent number: 5871903Abstract: Two new isolates of the Hepatitis C virus (HCV), J1 and J7, are disclosed. These new isolates comprise nucleotide and amino acid sequences which are distinct from the prototype HCV isolate, HCV1. Thus, J1 and J7 provide new polynucleotides and polypeptides for use, inter alia, in diagnostics, recombinant protein production and vaccine development.Type: GrantFiled: May 8, 1995Date of Patent: February 16, 1999Assignees: Chiron Corporation, The Director General of the National Institute of Health of JapanInventors: Tatsuo Miyamura, Izumi Saito
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Patent number: 5856437Abstract: Two new isolates of the Hepatitis C virus (HCV), J1 and J7, are disclosed. These new isolates comprise nucleotide and amino acid sequences which are distinct from the prototype HCV isolate, HCV1. Thus, J1 and J7 provide new polynucleotides and polypeptides for use, inter alia, in diagnostics, recombinant protein production and vaccine development.Type: GrantFiled: November 3, 1994Date of Patent: January 5, 1999Assignees: Chiron Corporation, The Director General of the National Institute of Health of JapanInventors: Tatsuo Miyamura, Izumi Saito, Michael Houghton, Amy J. Weiner, Jang Han, Janice A. Kolberg, Tai-An Cha, Bruce D. Irvine