Abstract: Provided is a method for generating a trained model for classifying blocking event data representing nanopore blocking events in a biomolecule measurement device. The method includes generating a first trained model by executing machine learning of a training model using first teacher data, the first teacher data includes teacher blocking event data and a teacher label, the teacher label indicates whether the teacher blocking event data is classified as Good data or bad data, and the first trained model is configured to classify the blocking event data into good data or bad data. In addition, a method for determining a base sequence a biomolecule and a biomolecule measurement device are provided.

Abstract: Provided are a method and a system for accurately distinguishing a micropartition in which a target gene or target DNA is placed and a micropartition in which a pseudogene is placed by a measuring device and accurately counting the target gene or target DNA in digital PCR using melting curve analysis. The method includes the steps of: placing a DNA solution in each of a plurality of partitions; performing PCR; changing a temperature of each of the partitions and measuring a fluorescence intensity; calculating a melting temperature of a double strand DNA for each of the partitions; counting the number of partitions for each type of the DNA; outputting the number of partitions counted for each type of the DNA; and discriminating the first gene and the pseudogene based on the melting temperature and the number of the counted partitions.

Abstract: The purpose of the present invention is to provide a novel digital PCR analysis method. In the digital PCR analysis method disclosed herein, a method for detecting DNA is used, which includes the steps of: dividing a DNA solution containing a fluorescent-labeled probe or a DNA intercalator and a plurality of DNAs to be detected into a plurality of compartments; carrying out PCR in the compartments; measuring a fluorescence intensity in association with a change in temperature; calculating a melting temperature from a melting curve for a DNA double strand measured on the basis of a change in fluorescence intensity, which is associated with the change in temperature; and calculating a temperature difference between two points with a slope of a predetermined value on a melting curve indicating a change in the fluorescence intensity.

Abstract: Provided are a semiconductor device and a sensor system capable of achieving improvement of noise resistance. Thus, an output circuit 106a in the semiconductor device includes: input terminals 207n, 207p; and an output terminal 208; an output amplifier 201 connecting the input terminals 207n, 207p to the output terminal 208; a feedback element 203 returning the output terminal 208 to the input terminal 207n; a switching transistor 204; and a resistance element 206. A drain of the switching transistor 204 is connected to the input terminal 207n. The resistance element 206 is provided between a back gate of the switching transistor 204 and a power source Vdd and has impedance of a predetermined value or more for suppressing noise of a predetermined frequency generated at the input terminal 207n.

Abstract: An electronic circuit that recognizes a disconnected state from an outside during disconnection of a power supply line is provided. For this purpose, an electronic circuit includes: a load provided between a power supply line and an output terminal in the electronic circuit; a transistor provided between the load and the output terminal; a current generation circuit that generates current using a power supply voltage at a power supply line in the electronic circuit; and a control circuit that controls the transistor using a control voltage that changes according to the current generated by the current generation circuit.

Abstract: A biopolymer analysis device includes an insulating thin film that is made of an inorganic material, a first liquid tank and a second liquid tank that are separated by the thin film, a plurality of first electrodes that is arranged in the first liquid tank, and a second electrode that is disposed in the second liquid tank. A water-repellent liquid and a plurality of liquid droplets are introduced into the first liquid tank, the plurality of first electrodes is configured to be able to convey the plurality of droplets introduced into the first liquid tank by electro wetting on dielectric by applying a certain voltage, and the plurality of droplets is conveyed to portions coming into contact with the plurality of first electrodes, and is insulated from each other by the water-repellent liquid.

Abstract: The present disclosure provides a technique capable of manufacturing a measurement cell having a high specimen utilization ratio in the case of using a measurement cell that introduces a specimen into a surface hole. In the measurement cell manufacturing method according to the present disclosure, a measurement cell includes a channel wall protruding from the lower surface substrate toward the through-hole, and a specimen solution is introduced into a lower surface side space to introduce the specimen into the through-hole (see FIG. 1).

Abstract: A digital PCR measuring apparatus capable of measuring a melting curve with high accuracy is provided. The digital PCR measuring apparatus includes a temperature adjuster that controls a temperature of a sample container including a plurality of minute regions, a fluorescence measurement part that measures fluorescence intensity of a plurality of minute regions, and a controller that controls the temperature adjuster and the fluorescence measurement part. The controller controls the temperature adjuster to raise a temperature of the sample container, and, after removing air bubbles generated in the sample container, measures fluorescence intensity of a plurality of minute regions while controlling the temperature adjuster to lower the temperature of the sample container, and measures a melting curve of a plurality of the minute regions.

Abstract: An electronic circuit including an output circuit capable of reducing breakage while satisfying the characteristics of an output signal is provided. For this purpose, the electronic circuit includes output signal generation elements 201 and 202 configured to generate an output signal, switches 203 and 204, and a voltage monitor circuit 205 configured to monitor a voltage applied to an output terminal 112. Here, the output signal generation elements 201 and 202 are connected to the output terminal 112 via the switches 203 and 204, and the voltage monitor circuit 205 is configured to be able to measure a voltage higher than a power supply voltage VDD connected to the output signal generation element 201 and controls the switches 203 and 204 so as to disconnect the output signal generation elements 201 and 202 and the output terminal 112 when the voltage of the output terminal 112 becomes equal to or higher than a predetermined value set higher than the power supply voltage VDD.

Abstract: To prevent an output of an intermediate potential by suppressing sneaking of a current from a signal line to a power line at the time of disconnection of a power supply. A control circuit which receives a power supply voltage from a power line L11 and outputs an output signal to a signal line L12 includes: a load R11 which is provided between the power line and the signal line; a first transistor P11 which is provided between the load and the signal line; a second transistor P12 which is provided between a well of the first transistor and the power line; and a gate control circuit 15 which connects a gate terminal of the first transistor and a gate terminal of the second transistor to the signal line and turns off the first transistor and the second transistor, at the time of disconnection of a power supply.

Abstract: To prevent an output of an intermediate potential by suppressing sneaking of a current from a signal line to a power line at the time of disconnection of a power supply. A control circuit which receives a power supply voltage from a power line L11 and outputs an output signal to a signal line L12 includes: a load R11 which is provided between the power line and the signal line; a first transistor P11 which is provided between the load and the signal line; a second transistor P12 which is provided between a well of the first transistor and the power line; and a gate control circuit 15 which connects a gate terminal of the first transistor and a gate terminal of the second transistor to the signal line and turns off the first transistor and the second transistor, at the time of disconnection of a power supply.

Abstract: A biological sample analyzer includes: a camera 201a imaging a blood collection tube 209 containing a biological sample; an image processing section 201b and a comparative analysis section 206 that analyze the image imaged by the camera in order to extract an existence region of the biological sample; a light source 203a1, a photo sensor 203a2 and a liquid-level position detection section 203b that detect the amount of transmitted light in the blood collection tube 209 in order to detect a liquid-level position of the biological sample; and the comparative analysis section 206 that, based on the extracted existence region of the biological sample and the detected liquid-level position of the biological sample, identifies a determination target portion for a category of the biological sample, and acquires color information on the identified portion, in order to determine a category of the biological sample contained in the blood collection tube 209.

Abstract: Provided are a semiconductor device and a sensor system capable of achieving improvement of noise resistance. Thus, an output circuit 106a in the semiconductor device includes: input terminals 207n, 207p; and an output terminal 208; an output amplifier 201 connecting the input terminals 207n, 207p to the output terminal 208; a feedback element 203 returning the output terminal 208 to the input terminal 207n; a switching transistor 204; and a resistance element 206. A drain of the switching transistor 204 is connected to the input terminal 207n. The resistance element 206 is provided between a back gate of the switching transistor 204 and a power source Vdd and has impedance of a predetermined value or more for suppressing noise of a predetermined frequency generated at the input terminal 207n.

Abstract: The present invention addresses the problem of providing a novel digital PCR analysis method. One embodiment of the novel digital PCR analysis method is a DNA detection method including the steps of: partitioning a DNA solution containing a fluorescent-labeled probe or a DNA intercalator and a target DNA to be detected into a plurality of compartments; carrying out a nucleic acid amplification reaction in the compartments; measuring a fluorescence intensity in association with a temperature change; calculating a melting temperature of a DNA double strand based on a change in the fluorescence intensity in association with the temperature change; and calculating a ratio of a fluorescence intensity at a second temperature that is lower than a first temperature in association with the temperature change to that at the first temperature.

Abstract: A conventional power supply device has a problem in miniaturization. A power supply device generates a prediction value of an error signal from first and second error signals, and controls an output voltage so that the prediction value lies between first and second threshold values. The first error signal is obtained by converting an error voltage based on the difference between the output voltage and a reference voltage at a first timing. The second error signal is obtained by converting an error voltage based on the difference between the output voltage and the reference voltage at a second timing.

Abstract: An ultrasound diagnosis device includes: an ultrasound probe which transmits an ultrasound wave toward a examinee and receives a reflected wave from the examinee; and a main device which controls the transmitting and receiving of the ultrasound waves from the ultrasound probe and is operated to receive a receiving signal obtained by receiving the reflected wave from the examinee by the ultrasound probe, to generate an ultrasound image of the examinee, and to display the ultrasound image on a display screen, wherein the ultrasound probe includes a plurality of subarrays having a plurality of element circuits transmitting and receiving ultrasound signals and a plurality of reference voltage sources, and the plurality of subarrays and the plurality of reference voltage sources have a one-to-one correspondence.

Abstract: A compact delay circuit that can dynamically change delay time is configured. A probe includes an analog memory unit that accumulates electric charges corresponding to a reflected wave of an ultrasonic wave produced by a difference between the acoustic impedances on a plurality of capacitors 303 and in turn outputs the electric charges accumulated on the capacitors 303 to an analog memory unit 205. In accumulating electric charges, when a control signal Ctls_l that increases delay time of the reflected wave is inputted, the analog memory unit 205 accumulates the same electric charges on two or more of the capacitors 303 for a preset period, or in outputting electric charges, when a control signal Ctlo_l is inputted, the analog memory unit 205 outputs the electric charges accumulated on one of the capacitors 303 for a preset period.

Abstract: A sample liquid-surface position measurement device includes: a first light source that illuminates a side face of a container containing a sample; a first optical measurement sensor that is located on the opposite side of the container from the first light source, and measures transmitted light from the first light source; a first label position measuring unit that measures a position of a label affixed to the container; and an analysis section that calculates a liquid-surface position or an interface position of the sample in the container, from transmitted-light intensity data in a longitudinal direction of the container which is measured by the first optical measurement sensor, and from the position of the label in the longitudinal direction of the container which is measured by the first label position measuring unit.

Abstract: A biological sample analyzer includes: a camera 201a imaging a blood collection tube 209 containing a biological sample; an image processing section 201b and a comparative analysis section 206 that analyze the image imaged by the camera in order to extract an existence region of the biological sample; a light source 203a1, a photo sensor 203a2 and a liquid-level position detection section 203b that detect the amount of transmitted light in the blood collection tube 209 in order to detect a liquid-level position of the biological sample; and the comparative analysis section 206 that, based on the extracted existence region of the biological sample and the detected liquid-level position of the biological sample, identifies a determination target portion for a category of the biological sample, and acquires color information on the identified portion, in order to determine a category of the biological sample contained in the blood collection tube 209.

Abstract: A delay circuit and an ultrasonic imaging apparatus with the higher-accuracy delay time, the longer maximum delay time, and the lower power consumption are provided. An input line to which an analog input signal is input, a plurality of analog signal memory devices, an output line, a plurality of sampling switches that control connection/disconnection between the input line and the plurality of analog signal memory devices, a plurality of output switches that control connection/disconnection between the plurality of analog signal memory devices and the output line, and a clock generation part that generates sampling switch control signals for controlling the sampling switches and output switch control signals for controlling the output switches are provided, and phase of the sampling switch control signals may be shifted with respect to phase of the output switch control signals.