Abstract: Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from Dengue virus that are immunogenic and elicit a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against Dengue virus subtypes following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, immunogenic compositions, vaccines, subviral particles (SVPs), and virus-like particles (VLPs) comprising Dengue virus proteins or encoding polynucleotides. Methods of generating an immune response in a subject by administering the immunogens, vaccines, SVPs, VLPs, or immunogenic compositions thereof are provided. In particular, the immunogens comprise a Dengue virus protein, or an antibody binding portion thereof.

Abstract: Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from Dengue virus that are immunogenic and elicit a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against Dengue virus subtypes following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, immunogenic compositions, vaccines, subviral particles (SVPs), and virus-like particles (VLPs) comprising Dengue virus proteins or encoding polynucleotides. Methods of generating an immune response in a subject by administering the immunogens, vaccines, SVPs, VLPs, or immunogenic compositions thereof are provided. In particular, the immunogens comprise a Dengue virus protein, or an antibody binding portion thereof.

Abstract: Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from H3 influenza virus that are immunogenic and are capable of eliciting a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against H3 vims following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, vaccines, virus-like particles (VLPs) and compositions comprising the immunogens and vaccines. Methods of generating an immune response in a subject by administering the immunogens, vaccines, VLPs, or compositions thereof are provided. In particular, the immunogens comprise the hemagglutinin (HA) protein of H3 influenza vims strains.

Abstract: Provided herein are methods for generating a non-naturally occurring, broadly reactive, pan-epitopic antigen derived from a pathogen, such as a virus, bacterium, and the like, that is immunogenic and is capable of eliciting a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against the pathogen following introduction into a subject. Also provided is a non-naturally occurring immunogen generated using the methods, and vaccines and compositions comprising the immunogen. Methods of generating an immune response in a subject by administering the immunogen, vaccine, or composition are provided. In particular, the immunogen comprises the hemagglutinin (HA) or neuraminidase (NA) protein of influenza virus strains.

Abstract: Provided herein are methods for generating a non-naturally occurring, broadly reactive, pan-epitopic antigen derived from H3 influenza virus that is capable of eliciting a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against H3 virus following administration to a subject. Also provided is a non-naturally occurring immunogen generated using the methods, and vaccines and compositions comprising the immunogen. Methods of generating an immune response in a subject by administering the immunogen, vaccine, or composition are provided. In particular, the immunogen comprises the hemagglutinin (HA) protein of H3 influenza vims strains.

Abstract: Co-administration (for example, immunogenic cocktail compositions and/or prime boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides is provided. Coadministration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (for example, a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.

Abstract: Provided herein are optimized recombinant influenza HA polypeptides that elicit immune responses. Also provided are compositions and kits comprising the optimized HA polypeptides as well as methods of making and using the optimized HA polypeptides.

Abstract: The present invention provides co-administration (e.g., immunogenic cocktail and/or prime-boost regimens) of computationally optimized H5N1 influenza hemagglutinin (HA) polypeptides that. Co-administration of the optimized H5N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to multiple H5N1 influenza virus clades and strains.

Abstract: Provided herein are optimized, recombinant influenza HA polypeptides that elicit immune responses. Also provided are compositions and kits comprising the optimized HA polypeptides as well as methods of making and using the optimized HA polypeptides.

Abstract: The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.

Abstract: The present invention provides co-administration (e.g., immunogenic cocktail and/or prime-boost regimens) of computationally optimized H5N1 influenza hemagglutinin (HA) polypeptides that. Co-administration of the optimized H5N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to multiple H5N1 influenza virus clades and strains.

Abstract: The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.

Abstract: Provided herein are optimized, recombinant influenza HA polypeptides that elicit immune responses. Also provided are compositions and kits comprising the optimized HA polypeptides as well as methods of making and using the optimized HA polypeptides.

Abstract: The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.

Abstract: Smart notification appliances used in a mass notification system (MNS) have integrated software and distributed hardware for real time information to in-building, immediate vicinity and distributed recipients during emergency situations. Programmable control configurations in the smart notification appliances provide flexible installations. A distributed architecture system provides distributed intelligence in the smart notification appliances for maximum survivability and robust operation of the MNS. Audio messages are stored in each smart notification appliance with a one-to-one relationship to a speaker circuit. This configuration provides any circuit with either a live page or a plurality of preconfigured messages, in effect a multi-channel system limited only by the number of stored messages and controllable by software. Similarly, programmable light strobe intensity, flash rate and color may be controlled through the smart notification appliances.

Abstract: A mass notification system is disclosed. The system can include a communication network. The system can also include a number of network devices communicably coupled to the communication network, where at least two of the network devices are configured to generate a communication substantially simultaneously. The system can further include a server communicably coupled to the communication network and configured to control the plurality of network devices, where the server instructs the at least two of the plurality of network devices to generate the communication. The system can also include a first client communicably coupled to the communication network and comprising a user interface, where the first client is configured to communicate, via the user interface, with the server and the plurality of network devices.

Abstract: A mass notification system is disclosed. The system can include a communication network. The system can also include a number of network devices communicably coupled to the communication network, where at least two of the network devices are configured to generate a communication substantially simultaneously. The system can further include a server communicably coupled to the communication network and configured to control the plurality of network devices, where the server instructs the at least two of the plurality of network devices to generate the communication. The system can also include a first client communicably coupled to the communication network and comprising a user interface, where the first client is configured to communicate, via the user interface, with the server and the plurality of network devices.

Abstract: Smart notification appliances used in a mass notification system (MNS) have integrated software and distributed hardware for real time information to in-building, immediate vicinity and distributed recipients during emergency situations. Programmable control configurations in the smart notification appliances provide flexible installations. A distributed architecture system provides distributed intelligence in the smart notification appliances for maximum survivability and robust operation of the MNS. Audio messages are stored in each smart notification appliance with a one-to-one relationship to a speaker circuit. This configuration provides any circuit with either a live page or a plurality of preconfigured messages, in effect a multi-channel system limited only by the number of stored messages and controllable by software. Similarly, programmable light strobe intensity, flash rate and color may be controlled through the smart notification appliances.