Abstract: Described is a deuterated compound, and preparation method and use thereof The deuterated compound I has a structure as shown in Formula (I), wherein A is H or D, and at least one of eight As is D; M is H or an alkali metal, an alkaline earth metal, or an ammonium radical. The present invention provides use of the deuterated compound I as an internal standard for measuring the content of a metabolite II in a biological sample, wherein the metabolite II has a structure as shown in a Formula (II); wherein A is H; M is H or an alkali metal, an alkaline earth metal, or an ammonium radical. The present invention uses the deuterated compound I as an internal standard to quantitatively analysis the content of metabolite II at lower content in biological samples, which can not only meet the requirements for the lower limit of quantitation, but also meet the requirements for DMPK studies in clinical trials.

Abstract: The present disclosure relates to a damping system for a hydraulic coupling device, comprising: an output hub having a central axis and a torus which surrounds the central axis, a first track being arranged in the torus; a plurality of turbine mass assemblies uniformly distributed around the central axis, each turbine mass assembly comprising a turbine section, each turbine section carrying a plurality of blades and being provided with a second track corresponding to the first track; a roller that can roll along a roller track defined by the first track and a corresponding second track, so that the turbine mass assembly can move relative to the output hub and exert torque on the output hub; wherein each turbine mass assembly further comprises a mass plate fixedly connected to the turbine section, the output hub being arranged between the mass plate and the turbine section.