Abstract: An adapter for use with a centrifuge. Features of the adapter allow for less friction during extraction of the adapter and separation efficiency by preventing disturbances to the separated materials. In addition, the adapter includes features that support the walls of a sample container and prevent force from damaging the sample container during a centrifuge separation procedure.

Abstract: An adapter for use with a centrifuge. Features of the adapter allow for less friction during extraction of the adapter and separation efficiency by preventing disturbances to the separated materials. In addition, the adapter includes features that support the walls of a sample container and prevent force from damaging the sample container during a centrifuge separation procedure.

Abstract: This invention provides an improved particle-enhanced assay for determining the concentration of any of a wide range of analytes with a high degree of specificity, accuracy, and sensitivity, primarily by improving the measurement of particle aggregates. Analyte concentration is determined by effecting a particle-enhanced reaction in an assay medium and measuring the distribution of different sized aggregated particles in the reaction mixture by polarization intensity differential scattering. The particle size distribution is then compared with a standard curve to determine the concentration of the analyte in the sample.

Abstract: This invention provides methods of improving assays for the quantitation of a protein in a sample by enhancing equimolar detection of the protein. Detection is enhanced by modifying the reaction environment of the protein. This invention further provides improved reagent particles for use in the detection and/or quantitation of an analyte in a sample, where the reagent particles comprise two or more coatings of the same or a different substance, such as an antibody, immobilized on an insoluble particle. This invention further provides a method of increasing the sensitivity of particle-enhanced immunoassays by increasing the size of the aggregates that are formed in the assay. Aggregate size is increased by combining the sample with three different antibodies: an analyte-specific antibody immobilized on an insoluble particle, a second antibody specific analyte, and a linker antibody which specifically binds the second antibody but does not bind to the analyte.