Abstract: This present invention provides anti-C—C chemokine type 8 (CCR8) antibodies and antigen binding fragments thereof, methods of making the antibodies or antigen binding fragments thereof, and methods of use thereof to bind to human CCR8 on CCR8 expressing cells, e.g., tumor-infiltrating Treg cells, to remove CCR8 expressing cells, e.g, tumor-infiltrating Treg cells, to reduce or inhibit tumor growth and/or to treat cancer.

Abstract: An electronic assembly including: a housing for enclosing electronic components within. The housing includes an opening; an input-output port for allowing connection of at least one of the electronic components with at least one input-output device. The input-output port extends through the opening; and a flexibly resilient material integrated with the housing and arranged to partially cover the opening. The flexibly resilient material being dimensioned to complement the dimensions of the input-output port. Also provided is a method of producing the electronic assembly.

Abstract: Disclosed herein are methods and systems for identfying genetic mutation and molecular alterations via imaging and clinical proxies using machine learning techniques. A processor can receive an image of a tumor of a patient. The processor can execute a first model to identify one or more visual attributes of the tumor using the image of the tumor as input. The processor can execute a second model to predict a genetic mutation or molecular alterations of the patient using the one or more visual attributes as input. The processor can identify a therapy protocol associated with the tumor based on the genetic mutation.

Abstract: The present disclosure describes a radiation sensing and reporting devices, systems, and methods. The devices and systems are a flexible material that detects the presence of radiation over a surface area and reports the specific location and intensity of the radiation. An article is provided that includes a substrate; a plurality of radiation sensors, each radiation sensor of the plurality of radiation sensors being disposed at a corresponding position on the substrate; and alert circuitry coupled to the plurality of radiation sensors, wherein the alert circuitry indicates, in real time, a localized detection of radiation according to corresponding one or more positions on the substrate of a particular one or more radiation sensors of the plurality of radiation sensors.

Abstract: The present application relates to anti-PD-L1 antibodies and their use to detect PD-L1 in a sample from a subject. In some embodiments, the subject has been treated with a therapeutic anti-PD-L1 antibody and an anti-PD-L1 described herein does not compete for binding to PD-L1 with the therapeutic anti-PD-L1 antibody. In some embodiments, the anti-PD-L1 antibody is linked to a detectable moiety, such as a fluorophore and the anti-PD-L1 antibody is used to detect PD-L1 in a subject using flow cytometry.

Abstract: A method of adapting a first key-value store to a second key-value store may include determining a conversion strategy based on one or more characteristics of the first key-value store and one or more characteristics of the second key-value store, converting the second key-value store to a converted key-value store based on the conversion strategy, and mapping the first key-value store to the converted key-value store based on a mapping function. The converted key-value store may be accessed on-the-fly. A data storage system may include a key-value interface configured to provide access to a lower key-value store, and a key-value adapter coupled to the key-value interface and configured to adapt an upper key-value store to the lower key-value store, wherein the key-value adapter may be configured to adapt at least two different types of the upper key-value store to the lower key-value store.

Abstract: An electronic assembly including: a housing for enclosing electronic components within. The housing includes an opening; an input-output port for allowing connection of at least one of the electronic components with at least one input-output device. The input-output port extends through the opening; and a flexibly resilient material integrated with the housing and arranged to partially cover the opening. The flexibly resilient material being dimensioned to complement the dimensions of the input-output port. Also provided is a method of producing the electronic assembly.

Abstract: The present application relates to anti-PD-L1 antibodies and their use to detect PD-L1 in a sample from a subject. In some embodiments, the subject has been treated with a therapeutic anti-PD-L1 antibody and an anti-PD-L1 described herein does not compete for binding to PD-L1 with the therapeutic anti-PD-L1 antibody. In some embodiments, the anti-PD-L1 antibody is linked to a N detectable moiety, such as a fluorophore and the anti-PD-L1 antibody is used to detect PD-L1 in a subject using flow cytometry.

Abstract: A load balancing system includes: a centralized queue; a pool of resource nodes connected to the centralized queue; one or more processors; and memory coupled to the one or more processors and storing instructions that, when executed by the one or more processors, cause the one or more processors to: monitor a queue status of the centralized queue to identify a bursty traffic period; calculate an index value for a load associated with the bursty traffic period; select a load balancing strategy based on the index value; distribute the load to the pool of resource nodes based on the load balancing strategy; observe a state of the pool of resource nodes in response to the load balancing strategy; calculate a reward based on the observed state; and adjust the load balancing strategy based on the reward.

Abstract: A method of adapting a first key-value store to a second key-value store may include determining a conversion strategy based on one or more characteristics of the first key-value store and one or more characteristics of the second key-value store, converting the second key-value store to a converted key-value store based on the conversion strategy, and mapping the first key-value store to the converted key-value store based on a mapping function. The converted key-value store may be accessed on-the-fly. A data storage system may include a key-value interface configured to provide access to a lower key-value store, and a key-value adapter coupled to the key-value interface and configured to adapt an upper key-value store to the lower key-value store, wherein the key-value adapter may be configured to adapt at least two different types of the upper key-value store to the lower key-value store.

Abstract: A load balancing system includes: a centralized queue; a pool of resource nodes connected to the centralized queue; one or more processors; and memory coupled to the one or more processors and storing instructions that, when executed by the one or more processors, cause the one or more processors to: monitor a queue status of the centralized queue to identify a bursty traffic period; calculate an index value for a load associated with the bursty traffic period; select a load balancing strategy based on the index value; distribute the load to the pool of resource nodes based on the load balancing strategy; observe a state of the pool of resource nodes in response to the load balancing strategy; calculate a reward based on the observed state; and adjust the load balancing strategy based on the reward.

Abstract: The present application relates to anti-PD-L1 antibodies and their use to detect PD-L1 in a sample from a subject. In some embodiments, the subject has been treated with a therapeutic anti-PD-L1 antibody and an anti-PD-L1 described herein does not compete for binding to PD-L1 with the therapeutic anti-PD-L1 antibody. In some embodiments, the anti-PD-L1 antibody is linked to a N detectable moiety, such as a fluorophore and the anti-PD-L1 antibody is used to detect PD-L1 in a subject using flow cytometry.

Abstract: Systems and method for high-speed single-pixel quantitative phase contrast optical imaging are provided. This imaging technique can bypass the use of conventional image sensors and their associated speed limitations. The quantitative phase images can be acquired much faster than conventional quantitative phase imaging by a chirped-wavelength-encoding mechanism via wavelength-swept laser sources or optical time-stretch based on optical fibers, without the need for interferometric approaches.

Abstract: Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.

Abstract: The invention provides anti-idiotypic HCMV antibodies as well as methods of using the same.

Abstract: A system and method are provided for capturing hearing characteristics from self-administered hearing tests or from professionally administered hearing tests, including loudness tolerance levels as at different sound frequencies, as an individualized audiological profile for automatically enhancing audio to complement and address as closely as possible an individual's hearing deficits. The user may self-administer a hearing test on a convenient personal apparatus, such as a smartphone. The system includes the ability for capturing an environment profile. The user's hearing is protected against harm in the enhanced audio setting while being provided with the option of a “enhanced hearing” experience. The invention is useful for any individual seeking an enhanced hearing experience, whether having hearing within normal range or hearing that is impaired. Thus the system is useful as a hearing aid.

Abstract: The invention provides anti-idiotypic HCMV antibodies as well as methods of using the same.

Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.

Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.

Abstract: The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.