Abstract: Bacterial resistance to antibiotics is increasing worldwide creating a global threat. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, is a bacterial infectious disease that results in over one million deaths annually. The discovery outlined here involves a tablet composition for patient administration and subsequently a new paradigm in drug delivery vehicles in vivo and in vitro and is applied to existing TB antibiotics in order to increase their efficacy. The drug delivery system is a three component complex that is administered with the TB antibiotic or a combination of TB antibiotics. The components are a saccharide or saccharides, a transition metal ion or a combination of metal ions that can bind a nitrogen and/or oxygen atom(s), and a water soluble polymer capable of aggregating and enclosing the other constituents. The three component molecular delivery approach has demonstrated ability to overcome M. tuberculosis bacterial resistance to an existing antibiotic.

Abstract: Many types of artificial reefs have been deployed in the world's oceans, bays and estuaries. These range from sinking ships to dispersing old building debris. In most approaches, the material placed in the marine environment lacks any nutrients needed for growth or concern regarding proper chemical conditions necessary to start and sustain life. In this discovery, concrete is made from both inorganic and organic components. The inorganic components are selected to include species that will be used to create a receptive surface to start and sustain life. Moreover, other conditions such as pH, chemical toxicity, nutrient levels and biodegradability are considered in the formulation. Additionally, there is an organic component that is part of the concentration mixture which provides trace nutrients and serves to weaken the structures so it will biodegrade over time. The biodegradable concrete slowly releases small quantities of resources (over months and years) providing a steady flux of essential nutrients.

Abstract: Bacterial resistance to antibiotics is increasing worldwide creating a global threat. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, is a bacterial infectious disease that results in over one million deaths annually. The discovery outlined here involves a tablet composition for patient administration and subsequently a new paradigm in drug delivery vehicles in vivo and in vitro and is applied to existing TB antibiotics in order to increase their efficacy. The drug delivery system is a three component complex that is administered with the TB antibiotic or a combination of TB antibiotics. The components are a saccharide or saccharides, a transition metal ion or a combination of metal ions that can bind a nitrogen and/or oxygen atom(s), and a water soluble polymer capable of aggregating and enclosing the other constituents. The three component molecular delivery approach has demonstrated ability to overcome M. tuberculosis bacterial resistance to an existing antibiotic.