Patents by Inventor Tetsuhiro Harakawa

Tetsuhiro Harakawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Highly purified type A toxin preparation from infant botulism pathogen
    Patent number: 9278133
    Abstract: A novel type A botulinum toxin preparation is provided. A neuromuscular transmission blocking agent comprising as an active ingredient a highly purified type A botulinum toxin from Clostridium botulinum as infant botulism pathogen and a medicament for treating a disease with a muscle overactivity comprising as an active ingredient said toxin. In particular, the medicament of the present invention, as compared to the conventional known botulinum toxin preparations, has rapid efficacy of potential and is less diffusive and thus, having a broader safety margin, may be used as therapeutic medicament for decreasing local, muscle overactivity in a disease with a muscle overactivity.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: March 8, 2016
    Assignees: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE, TOKUSHIMA UNIVERSITY
    Inventors: Tetsuhiro Harakawa, Hirotoshi Nakano, Yasushi Torii, Yoshitaka Goto, Miho Shinmura, Sachio Okuda, Ryuji Kaji, Shunji Kosaki
  • Method for quantification of neurotoxin
    Patent number: 8949033
    Abstract: The present invention relates to a method for quantitatively measuring the muscular relaxing activity of a neurotoxin.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: February 3, 2015
    Assignees: The Chemo-Sero-Therapeutic Research Institute, Japan as represented by Director General of National Institute of Infectious Diseases
    Inventors: Tetsuhiro Harakawa, Hirotoshi Nakano, Yasushi Torii, Sachio Okuda, Ryuji Kaji, Takashi Sakamoto, Motohide Takahashi, Setsuji Ishida
  • Method for quantification of neurotoxin
    Patent number: 8577618
    Abstract: The present invention relates to a method for quantitatively measuring the muscular relaxing activity of a neurotoxin.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: November 5, 2013
    Assignees: The Chemo-Sero-Therapeutic Research Institute, Japan as represented by Director Genereal of National Institute of Infectious Diseases
    Inventors: Tetsuhiro Harakawa, Hirotoshi Nakano, Yasushi Torii, Sachio Okuda, Ryuji Kaji, Takashi Sakamoto, Motohide Takahashi, Setsuji Ishida
  • METHOD FOR QUANTIFICATION OF TITER OF NEUTRALIZING ANTIBODY TO NEUROTOXIN
    Publication number: 20110105940
    Abstract: A method for quantification of a titer of a neutralizing antibody to a neurotoxin is disclosed. The method comprises the steps: (a) mixing a standard sample containing a fixed amount of a neurotoxin and a test sample containing a neutralizing antibody to said neurotoxin; (b) administering the mixture obtained in step (a) into the muscle of a non-human mammal; (c) applying electric stimulus to said non-human mammal; (d) measuring a compound muscle action potential (CMAP) due to contraction of the muscle of said mammal by application of electric stimulus with an electromyograph; and (e) analyzing CMAP amplitude data obtained in step (d) for an extent of decrease in amplitude by a non-neutralized neurotoxin to thereby quantify a titer of the neutralizing antibody contained in the test sample.
    Type: Application
    Filed: August 20, 2008
    Publication date: May 5, 2011
    Applicants: JURIDICAL FDN THE CHEMO-SERO-THERAPEUTIC RES. INS., JP AS REP BY DIR-GEN NATL INST OF INFECTIOUS DIS
    Inventors: Yasushi Torii, Tetsuhiro Harakawa, Yoshitaka Goto, Akihiro Ginnaga, Ryuji Kaji, Shunji Kozaki, Motohide Takahashi
  • Highly Purified Type A Botulinum Toxin Preparation From Infant Botulism Pathogen
    Publication number: 20100173841
    Abstract: A novel type A botulinum toxin preparation is provided. A neuromuscular transmission blocking agent comprising as an active ingredient a highly purified type A botulinum toxin from Clostridium botulinum as infant botulism pathogen and a medicament for treating a disease with a muscle overactivity comprising as an active ingredient said toxin. In particular, the medicament of the present invention, as compared to the conventional known botulinum toxin preparations, has rapid efficacy of potential and is less diffusive and thus, having a broader safety margin, may be used as therapeutic medicament for decreasing local, muscle overactivity in a disease with a muscle overactivity.
    Type: Application
    Filed: October 26, 2007
    Publication date: July 8, 2010
    Applicant: Juridical Foundation the Chemo-Sero-Therapeutic Research Institute
    Inventors: Tetsuhiro Harakawa, Hirotoshi Nakano, Yasushi Torii, Yoshitaka Goto, Miho Shinmura, Sachio Okuda, Ryuji Kaji, Shunji Kosaki
  • METHOD FOR QUANTIFICATION OF NEUROTOXIN
    Publication number: 20090297452
    Abstract: The present invention relates to a method for quantitatively measuring the muscular relaxing activity of a neurotoxin.
    Type: Application
    Filed: April 28, 2006
    Publication date: December 3, 2009
    Inventors: Tetsuhiro Harakawa, Hirotoshi Nakano, Yasushi Torii, Sachio Okuda, Ryuji Kaji, Takashi Sakamoto, Matohide Takahashi, Setsuji Ishida