Abstract: Platinum complexes of cis-diaminocyclohexanol or cis-diaminocyclohexane, with the exclusion of platinum complexes of 2-deoxystreptamine, having high anti-tumor activity, low toxicity, water-solubility and exhibiting no cross-resistance to cis-platin.

Abstract: 6-Iodoethylated starch and process for preparing the same are disclosed. The 6-idodethylated starch contains one iodine attached per 5 glucose units. Said compound is useful as a contrast agent for X-ray examination, especially for opacifying the vascular os lymphatic vessel. Said compound is produced by reacting 6-hydroxyethylated starch with N-iodosuccinimide in the presence of triphenylphosphine.

Abstract: Novel nitrosourea derivatives are provided which possess a high level of inhibitory activity against leukemia and tumors and which are therefore useful for pharmaceutical purposes. The compounds have the structure represented by formula (I): ##STR1## wherein R.sub.0 represents --OH or --OC.sub.m H.sub.2m+1 where m is an integer of 1 to 3 and one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represents ##STR2## where X is ##STR3## or an alkylene group of 1 to 3 carbon atoms, n is an integer of 1 to 3 and Y is the group on the .alpha.-carbon atom of an .alpha.-amino acid and each of the remaining three represents --OH; or wherein R.sub.0 represents ##STR4## and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each represent --OH; or by formula (II): ##STR5## wherein X and n have the same meanings as above; and p is an integer of 1 to 5.

Abstract: Nitrosourea derivatives are provided which possess a high level of inhibitory activity against leukemia and tumors and which are therefore useful for pharmaceutical purposes. The compounds have the structure represented by formulae (I), (II) and (III): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.4 may be the same or different and each represent a hydrogen atom or an alkyl, aryl, aralkyl, alkanoyl or a heterocyclic group; R.sup.3 represents the residual group on the .alpha.-carbon atom of an .alpha.-amino acid; n represents 2 or 3; X represents a halogen atom selected from chlorine, fluorine and bromine; and Ac represents an alkanoyl group.

Abstract: Novel nitrosourea derivatives of sucrose having a structure expressed by the general formula: ##STR1## wherein A.sup.1 and A.sup.2 denote a group of OR or ##STR2## either A.sup.1 or A.sup.2 represents a group of ##STR3## and R shows a hydrogen atom or acyl group, and a method of manufacturing said derivatives. Said novel nitrosourea derivatives of sucrose have antitumor activity.

Abstract: 5,6-Dideoxyneamine, useful as an antimicrobial agent, and a process for preparing 5,6-dideoxyneamine.

Abstract: Novel nitrosourea derivatives are provided which possess a high level of inhibitory activity against leukemia and tumors and other are therefore useful for pharmaceutical purposes. The compounds have the structure: ##STR1## wherein one of X and Y represents a hydroxyl and another of them represents a group --NHCONNOCH.sub.2 CH.sub.2 Cl; R represents a hydrogen, alkyl or aryl; and .about. represents a single bond which may be in the .alpha.- or .beta.-stereochemical configuration and are prepared by nitrosating a corresponding urea compound with a nitrosating agent in a manner known per se.

Abstract: Novel nitrosourea compounds are provided which possess a high level of inhibitory activity against leukemia and tumors with a low toxicity and which are therefore useful for pharmaceutical purposes. The compounds have the chemical structure: ##STR1## wherein .about. represents a single bond which may be in the .alpha.- or .beta.-position and are prepared by nitrosating a urea compound of the formula: ##STR2## with a nitrosating agent in a manner known per se.

Abstract: New nitrosourea derivatives are provided, which possess a high inhibitory activity against the leukemia and tumors with a low toxicity and which are useful for pharmaceutical purposes. The compounds have the formula ##STR1## wherein A represents a glycosyl group, a monovalent residue of methyl glucoside or of alditol, a N-substituted carbamoyloxyalkyl group or a hydroxy-substituted cyclohexyl group when n is 1, or A represents a tetravalent residue of ribostamycin when n is 4 and R represents a lower alkyl or halo-alkyl group and are prepared by treating a compound of the formula ##STR2## with a nitrosating agent.

Abstract: Novel nitrosourea derivatives are provided which possess a high inhibitory activity against the leukemia and tumors with a low toxicity and a good stability against humidity and which are useful for pharmaceutical purposes. The compounds have the structure: ##STR1## wherein R.sup.1 represents hydroxyl or alkanoyloxy containing 2-4 carbon atoms; R.sup.2 represents hydrogen or alkanoyl containing 2-4 carbon atoms; R.sup.3 represents alkanoyl containing 2-4 carbon atoms; and R.sup.4 represents alkyl or halo-substituted alkyl containing 1-4 carbon atoms.

Abstract: Novel inosadiamine derivatives of the formula ##STR1## exhibit high effectiveness against various mammalian tumor systems.

Abstract: 5,6-Epineamine represented by the formula (I) ##STR1## and a process for preparing 5,6-epineamine of the formula (I) above which comprises hydrolyzing the epoxy group of a compound of the formula (II) ##STR2## wherein R.sup.1 represents a protective group for an amino group and R.sup.2 represents a protective group for a hydroxyl group, and removing the protective groups for the amino and hydroxyl groups.

Abstract: Aminocyclitol derivatives, 5-deoxyneamine and 6-deoxyneamine, having antimicrobial activities against various antibiotic-resistant microorganisms, a process for producing 5-deoxyneamine and 6-deoxyneamine and intermediates useful in producing the aminocyclitol derivatives.

Abstract: New nitrosourea derivatives are provided, which possess a high inhibitory activity against the leukemia and tumors with a low toxicity and which are useful for pharmaceutical purposes. The compounds have the formula ##STR1## WHEREIN A represents a glycosyl group, a monovalent residue of methyl glucoside or of alditol, a N-substituted carbamoyloxyalkyl group or a hydroxy-substituted cyclohexyl group when n is 1, or A represents a tetravalent residue of ribostamycin when n is 4 and R represents a lower alkyl or halo-alkyl group and are prepared by treating a compound of the formula ##STR2## WITH A NITROSATING AGENT.

Abstract: Novel water-soluble nitrosourea derivatives of the formula ##STR1## WHEREIN R represents a 2', 3', 4', 5'-tetrahydroxycyclopentyl group exhibit high effectiveness in various animal tumor systems.

Abstract: 2,5-Dideoxystreptamine is provided which is a new compound useful in the fermentative production of 5-deoxyneamine having useful antibacterial activity by culturing a microorganism. The production of 2,5-dideoxystreptamine is made by catalytic hydrogenation of 6,7-diaza-bicyclo[3.2.1]octane-2,4-diol which is also a new compound.