Patents by Inventor Tetsuro Yamasaki

Tetsuro Yamasaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6489273
    Abstract: A fragrance, having a 2-cyclohexyl-1,1-dimethyl ethanol derivative represented by formula (1), wherein R represents a hydrogen atom or an acetyl group, Me represents a methyl group and n represents an integer from 0 to 3, provides a very pleasing scent, has excellent stability in a product, and can be mixed well with other fragrances.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: December 3, 2002
    Assignee: Takasago International Corporation
    Inventors: Takashi Aida, Hiroyuki Matsuda, Tetsuro Yamasaki
  • Patent number: 6440400
    Abstract: The present invention is a trimethylcyclohexane derivative represented by Formula (1): wherein A represents C═O or CH—OH, n represents 2, R1 represents hydrogen or a methyl group, R2 represents a straight or branched, saturated or unsaturated hydrocarbon group having 3 to 10 carbon atoms, and a dotted line represents a saturated or unsaturated carbon-carbon bond, a melanin production inhibitor and a fragrance fixative comprising one or more of the trimethylcyclohexane derivatives, and a dermal formulation comprising one or more of the melanin production inhibitors and/or fragrance fixatives.
    Type: Grant
    Filed: August 2, 2000
    Date of Patent: August 27, 2002
    Assignee: Takasago International Corporation
    Inventors: Takashi Aida, Hiroyuki Matsuda, Kenya Ishida, Tetsuro Yamasaki, Eiko Tamai, Kazuhiko Tokoro
  • Patent number: 6379659
    Abstract: A keratin fiber strengthening agent comprising 0.001 to 20% by weight of at least one (2S,3R)-2-acylaminoalkane-1,3-diol represented by formula (I): wherein R1 represents a straight-chain alkyl group having 9 to 17 carbon atoms; and R2 represents an acyl group having 2 to 24 carbon atoms which may contain at least one hydroxy group or unsaturated bond is disclosed. A method for improving physical properties, such as breaking strength, of keratin fiber such as hair comprising applying the keratin fiber strengthening agent to keratin fiber by adhesion, coating or impregnation is also disclosed.
    Type: Grant
    Filed: November 17, 1998
    Date of Patent: April 30, 2002
    Assignee: Takasago International Corporation
    Inventors: Kenya Ishida, Kazutoshi Sakurai, Miharu Ogura, Tetsuro Yamasaki, Kenichiro Shiroyama
  • Patent number: 6084138
    Abstract: An (E)-(R)-2-alkyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)-2-buten-1-ol represented by formula (I): ##STR1## wherein R represents an alkyl group having 1 to 3 carbon atoms, and a process for preparing the same comprising hydrogenating a corresponding (E)-(R)-2-alkyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)-2-buten-1-al in the presence of a ruthenium-phosphine complex as a catalyst, a base comprising an alkali metal or an alkaline earth metal, and an amine. The compound (I) has an excellent sandalwood oil odor.
    Type: Grant
    Filed: July 1, 1998
    Date of Patent: July 4, 2000
    Assignee: Takasago International Corporation
    Inventors: Takashi Aida, Makoto Harada, Takeshi Yamamoto, Hisao Iwai, Akira Amano, Tetsuro Yamasaki
  • Patent number: 5994291
    Abstract: An (E)-(R)-2-alkyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)-2-buten-1-ol represented by formula (I): wherein R represents an alkyl group having 1 to 3 carbon atoms,and a process for preparing the same comprising hydrogenating a corresponding (E)-(R)-2-alkyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)-2-buten-1-al in the presence of a ruthenium-phosphine complex as a catalyst, a base comprising an alkali metal or an alkaline earth metal, and an amine. The compound (I) has an excellent sandalwood oil odor.
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: November 30, 1999
    Assignee: Takasago International Coporation
    Inventors: Takashi Aida, Makoto Harada, Takeshi Yamamoto, Hisao Iwai, Akira Amano, Tetsuro Yamasaki
  • Patent number: 5837828
    Abstract: The present invention concerns neutral sugar derivatives of pradimicins, their use as antifungal agents, methods for their preparation, and intermediates for their synthesis.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: November 17, 1998
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Shimpei Aburaki, Tetsuro Yamasaki, Toshikazu Oki, Seiji Iimura, Hajime Kamachi, Hideo Kamei, Takayuki Naito
  • Patent number: 5808162
    Abstract: A novel chiral unsymmetric diphosphine compound of formula (I): ##STR1## wherein Ar.sup.1 and Ar.sup.2, which are different from each other, each represent a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a pyridyl group, a quinolyl group, an isoquinolyl group, a furfuryl group, a benzofurfuryl group, a thienyl group, or a benzothienyl group, and a transition metal complex containing the diphosphine compound as a ligand. The complex catalyzes various asymmetric synthesis reactions, e.g., asymmetric hydrogenation or asymmetric hydrosilylation, exhibiting excellent performance in selectivity, conversion and catalytic activity, to provide a product of desired absolute configuration at high optical purity and in high yield.
    Type: Grant
    Filed: July 18, 1996
    Date of Patent: September 15, 1998
    Assignee: Takasago International Corporation
    Inventors: Noboru Sayo, Xiaoyong Zhang, Tatsuya Omoto, Tohru Yokozawa, Tetsuro Yamasaki, Hidenori Kumobayashi
  • Patent number: 5631397
    Abstract: Disclosed herein is a process for producing a (2S,5S)-2,5-diamino-1,6-diphenyl-3-hexanone derivative represented by the formula (1): ##STR1## wherein R.sup.1 means a lower alkylcarbonyl group, a halogen-substituted lower alkylcarbonyl group, an arylcarbonyl group or a lower alkoxycarbonyl group, and R.sup.2 and R.sup.3 are identical with or different from each other and denote individually an aryl group or an alkoxy-substituted aryl group, which comprises subjecting a (2S)-2,5-diamino-1,6-diphenyl-4-hexen-3-one derivative represented by the formula (2): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 have the same meaning as defined above, to a hydrogenation reaction in the presence of a transition metal-containing catalyst.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 20, 1997
    Assignee: Takasago International Corporation
    Inventors: Tetsuro Yamasaki, Hidenori Kumobayashi, Noboru Sayo, Toshiyuki Murayama, Noboru Sano, Takero Ishizaki
  • Patent number: 5581007
    Abstract: A process for preparing an optically active (2S,3S)-allophenylnorstatin derivative (I) is disclosed, comprising asymmetrically hydrogenating a 4-phenyl-2-halogeno-3-oxobutyric ester (III) in the presence of a ruthenium-phosphine complex to obtain a 4-phenyl-(2S)-halogeno-(3R)-hydroxybutyric ester (IV), epoxidizing the ester (IV) in the presence of a base to obtain a 4-phenyl-(2S,3R)-epoxybutyric ester (V), reacting the ester (V) with a tri(lower alkyl)silylazide or a (lower alkyl)diarylsilylazide in the presence of a Lewis to obtain a (3S)-azido-4-phenyl-(2S)-trisubstituted silyloxybutyric ester (VI), hydrogenolyzing the ester (VI) into a (2S,3S)-allophenylnorstatin derivative (VII), protecting the amino group of the compound (VII), and, if desired, hydrolyzing the compound before or after the amino group protection. Compounds (I) can be obtained at high optical purity safely and in good yield.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: December 3, 1996
    Assignee: Takasago International Corporation
    Inventors: Noboru Sayo, Tetsuro Yamasaki, Hidenori Kumobayashi, Yoshifumi Yuasa, Tsukasa Sotoguchi
  • Patent number: 5523458
    Abstract: Disclosed herein is a process for producing a (2S,5S)-2,5-diamino-1,6-diphenyl-3-hexanone derivative represented by the formula (1): ##STR1## wherein R.sup.1 means a lower alkylcarbonyl group, a halogen-substituted lower alkylcarbonyl group, an arylcarbonyl group or a lower alkoxycarbonyl group, and R.sup.2 and R.sup.3 are identical with or different from each other and denote individually an aryl group or an alkoxy-substituted aryl group, which comprises subjecting a (2S)-2,5-diamino-1,6-diphenyl-4-hexen-3-one derivative represented by the formula (2): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 have the same meaning as defined above, to a hydrogenation reaction in the presence of a transition metal-containing catalyst.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: June 4, 1996
    Assignee: Takasago International Corporation
    Inventors: Tetsuro Yamasaki, Hidenori Kumobayashi, Noboru Sayo, Toshiyuki Murayama, Noboru Sano, Takero Ishizaki
  • Patent number: 5466450
    Abstract: A novel antibiotic complex designated BU-4224V produced by fermentation of Kibdelosporangium albatum sp. nov. Strain R761-7. The complex may be separated chromatographically into bioactive components designated BU-4224V A, B.sub.1, B.sub.2, and C. The components BU-4224V B.sub.1 and B.sub.2 display both antiviral and antimicrobial activity, while component BU-4224V A has antimicrobial activity and component BU-4224V C has antiviral activity.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: November 14, 1995
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Mitsuaki Tsunakawa, Tetsuro Yamasaki, Koji Tomita, Osamu Tenmyo
  • Patent number: 5410029
    Abstract: The present invention concerns neutral sugar derivatives of pradimicins, their use as antifungal agents, methods for their preparation, and intermediates for their synthesis.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: April 25, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventors: Shimpei Aburaki, Tetsuro Yamasaki, Toshikazu Oki, Seiji Iimura, Hajime Kamachi, Hideo Kamei, Takayuki Naito
  • Patent number: 5256646
    Abstract: A novel antibiotic complex designated BU-4224V produced by fermentation of Kibdelosporangium albatum sp. nov. Strain R761-7. The complex may be separated chromatographically into bioactive components designated BU-4224V A, B.sub.1, B.sub.2, and C. The components BU-4224V B.sub.1 and B.sub.2 display both antiviral and antimicrobial activity, while component BU-4224V A has antimicrobial activity and component BU-4224V C has antiviral activity.
    Type: Grant
    Filed: July 27, 1990
    Date of Patent: October 26, 1993
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mitsuaki Tsunakawa, Tetsuro Yamasaki, Koji Tomita, Osamu Tenmyo
  • Patent number: 4912204
    Abstract: The present invention provides antitumor fluoro-substituted 4'-demethylepipodophyllotoxin glucosides.
    Type: Grant
    Filed: September 6, 1988
    Date of Patent: March 27, 1990
    Assignee: Bristol-Myers Company
    Inventors: Takeshi Ohnuma, Tetsuro Yamasaki, Hideo Kamei, Takayuki Naito
  • Patent number: 4278675
    Abstract: A bronchodilating process employing purine derivatives "9-cyclohexyl-9H-adenine er 9-benzyl-2-n-propoxy-9H-adenine" is disclosed.
    Type: Grant
    Filed: September 13, 1979
    Date of Patent: July 14, 1981
    Assignee: Bristol-Myers Company
    Inventors: Takayuki Naito, Susumu Nakagawa, Tetsuro Yamasaki, Taka-aki Okita, Haruhiro Yamashita
  • Patent number: 4269839
    Abstract: Adenine derivatives with 2-alkylthio and 9-(2-cyclohexenyl or cyclohexyl) substituents having non-adrenergic bronchodilating properties and use in the treatment or prophylaxis of broncho-constriction in mammals are disclosed.
    Type: Grant
    Filed: September 13, 1979
    Date of Patent: May 26, 1981
    Assignee: Bristol-Myers Company
    Inventors: Takayuki Naito, Susumu Nakagawa, Tetsuro Yamasaki, Taka-aki Okita, Haruhiro Yamashita
  • Patent number: 4241063
    Abstract: New 2-substituted-6-amino-9-tetrahydropyran-2-yl purine derivatives are disclosed. They are orally active bronchodilators with relatively little cardiovascular side effects. A representative and preferred embodiment of this invention is 2-n-propoxy-9-(tetrahydropyran-2-yl)-9H-adenine.
    Type: Grant
    Filed: August 6, 1979
    Date of Patent: December 23, 1980
    Assignee: Bristol-Myers Company
    Inventors: Takayuki Naito, Susumu Nakagawa, Tetsuro Yamasaki, Taka-aki Okita, Haruhiro Yamashita
  • Patent number: 4232155
    Abstract: New orally active bronchodilating 6-amino-purine derivatives substituted in the two position with alkylamino or cyclohexylamino and in the nine position with 2-cyclohexenyl or cyclohexyl are disclosed.
    Type: Grant
    Filed: September 13, 1979
    Date of Patent: November 4, 1980
    Assignee: Bristol-Myers Company
    Inventors: Takayuki Naito, Susumu Nakagawa, Tetsuro Yamasaki, Taka-Aki Okita, Haruhiro Yamashita
  • Patent number: 4201860
    Abstract: Purine derivatives of the formula ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl and R.sub.1 is ##STR2## and their pharmaceutically acceptable acid addition salts are non-adrenergic bronchodilators.
    Type: Grant
    Filed: January 4, 1979
    Date of Patent: May 6, 1980
    Assignee: Bristol-Myers Company
    Inventors: Takayuki Naito, Susumu Nakagawa, Tetsuro Yamasaki, Taka-aki Okita, Haruhiro Yamashita
  • Patent number: 4172829
    Abstract: Purine derivatives of the formula ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl and R.sub.1 is ##STR2## OR ##STR3## AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS ARE NON-ADRENERGIC BRONCHODILATORS.
    Type: Grant
    Filed: May 9, 1978
    Date of Patent: October 30, 1979
    Assignee: Bristol-Myers Company
    Inventors: Takayuki Naito, Susumu Nakagawa, Tetsuro Yamasaki, Taka-aki Okita, Haruhiro Yamashita