Patents by Inventor Tetsushi Kawahara

Tetsushi Kawahara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-CD14 ANTIBODY FUSION PROTEIN
    Publication number: 20140050727
    Abstract: A protein comprising (I) an anti-CD14 antibody or its active fragment, or a derivative thereof and (II) an inhibitor for a protease, or its active fragment, or a derivative thereof is provided.
    Type: Application
    Filed: August 21, 2013
    Publication date: February 20, 2014
    Applicant: Mochida Pharmaceutical Co., Ltd.
    Inventors: Shoji FURUSAKO, Kazuyuki NAKAYAMA, Yoshitaka HOSAKA, Tetsushi KAWAHARA, Masaki NAKAMURA, Takashi TAKEUCHI
  • ANTI-PLATELET MEMBRANE GLYCOPROTEIN VI MONOCLONAL ANTIBODY
    Publication number: 20140044723
    Abstract: The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
    Type: Application
    Filed: July 24, 2013
    Publication date: February 13, 2014
    Inventors: Hiroshi Takayama, Kamon Shirakawa, Shoji Furusako, Yoshitaka Hosaka, Tomokazu Matsusue, Katsuki Naitoh, Yumi Hotta, Tetsushi Kawahara, Motoyasu Honda
  • Polynucleotide encoding anti-CD14 antibody fusion protein
    Patent number: 8541565
    Abstract: A protein comprising (I) an anti-CD14 antibody or its active fragment, or a derivative thereof and (II) an inhibitor for a protease, or its active fragment, or a derivative thereof is provided.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: September 24, 2013
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Shoji Furusako, Kazuyuki Nakayama, Yoshitaka Hosaka, Tetsushi Kawahara, Masaki Nakamura, Takashi Takeuchi
  • Anti-platelet membrane glycoprotein VI monoclonal antibody
    Patent number: 8524870
    Abstract: The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: September 3, 2013
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Takayama, Kamon Shirakawa, Shoji Furusako, Yoshitaka Hosaka, Tomokazu Matsusue, Katsuki Naitoh, Yumi Hotta, Tetsushi Kawahara, Motoyasu Honda
  • Anti-platelet membrane glycoprotein VI monoclonal antibody
    Patent number: 8389692
    Abstract: The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
    Type: Grant
    Filed: April 27, 2011
    Date of Patent: March 5, 2013
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Takayama, Kamon Shirakawa, Shoji Furusako, Yoshitaka Hosaka, Tomokazu Matsusue, Katsuki Naitoh, Yumi Hotta, Tetsushi Kawahara, Motoyasu Honda
  • ANTI-CD14 ANTIBODY FUSION PROTEIN
    Publication number: 20120277412
    Abstract: A protein comprising (I) an anti-CD14 antibody or its active fragment, or a derivative thereof and (II) an inhibitor for a protease, or its active fragment, or a derivative thereof is provided.
    Type: Application
    Filed: July 12, 2012
    Publication date: November 1, 2012
    Inventors: Shoji FURUSAKO, Kazuyuki Nakayama, Yoshitaka Hosaka, Tetsushi Kawahara, Masaki Nakamura, Takashi Takeuchi
  • Anti-CD14 antibody fusion protein
    Patent number: 8252905
    Abstract: A protein comprising (I) an anti-CD14 antibody or its active fragment, or a derivative thereof and (II) an inhibitor for a protease, or its active fragment, or a derivative thereof is provided.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: August 28, 2012
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Shoji Furusako, Kazuyuki Nakayama, Yoshitaka Hosaka, Tetsushi Kawahara, Masaki Nakamura, Takashi Takeuchi
  • ANTI-PLATELET MEMBRANE GLYCOPROTEIN VI MONOCLONAL ANTIBODY
    Publication number: 20110217318
    Abstract: The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
    Type: Application
    Filed: April 27, 2011
    Publication date: September 8, 2011
    Inventors: HIROSHI TAKAYAMA, KAMON SHIRAKAWA, SHOJI FURUSAKO, YOSHITAKA HOSAKA, TOMOKAZU MATSUSUE, KATSUKI NAITOH, YUMI HOTTA, TETSUSHI KAWAHARA, MOTOYASU HONDA
  • Anti-platelet membrane glycoprotein VI monoclonal antibody
    Patent number: 7977461
    Abstract: The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: July 12, 2011
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Takayama, Kamon Shirakawa, Shoji Furusako, Yoshitaka Hosaka, Tomokazu Matsusue, Katsuki Naitoh, Yumi Hotta, Tetsushi Kawahara, Motoyasu Honda
  • ANTI-PLATELET MEMBRANE GLYCOPROTEIN VI MONOCLONAL ANTIBODY
    Publication number: 20090092612
    Abstract: The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
    Type: Application
    Filed: April 28, 2006
    Publication date: April 9, 2009
    Inventors: Hiroshi Takayama, Kamon Shirakawa, Shoji Furusako, Yoshitaka Hosaka, Tomokazu Matsusue, Katsuki Naitoh, Yumi Hotta, Tetsushi Kawahara, Motoyasu Honda
  • ANTI-PLATELET MEMBRANE GLYCOPROTEIN VI MONOCLONAL ANTIBODY
    Publication number: 20090041783
    Abstract: The present invention provides an antibody which has the following features, its active fragment, or a derivative thereof: a) It specifically binds to human platelet membrane glycoprotein VI (GPVI); b) The function to activate a platelet and/or the function to induce a thrombocytopenia in vivo are low; and c) It at least partially depletes GPVI on the platelet membrane by contacting with a platelet.
    Type: Application
    Filed: January 27, 2006
    Publication date: February 12, 2009
    Inventors: Hiroshi Takayama, Kamon Shirakawa, Shoji Furusako, Yoshitaka Hosaka, Tomokazu Matsusue, Katsuki Naitoh, Yumi Hotta, Tetsushi Kawahara
  • Anti-Cd14 Antibody Fusion Protein
    Publication number: 20080286290
    Abstract: A protein comprising (I) an anti-CD14 antibody or its active fragment, or a derivative thereof and (II) an inhibitor for a protease, or its active fragment, or a derivative thereof is provided.
    Type: Application
    Filed: June 5, 2006
    Publication date: November 20, 2008
    Inventors: Shoji Furusako, Kazayuki Nakayama, Yoshitaka Hosaka, Tetsushi Kawahara, Masaki Nakamura, Takashi Takeuchi
  • Monoclonal antibody against platelet membrane glycoprotein VI
    Publication number: 20070025992
    Abstract: The present invention provides a human antibody or an active-fragment thereof that specifically binds to human platelet membrane glycoprotein VI and does not induce a human platelet aggregation independently; a cell that produces the antibody or its active-fragment; a pharmaceutical composition that comprises the antibody or its active-fragment as an active ingredient, and so on. The above-mentioned cell can be obtained for example, as follows: a peripheral-blood-lymphocyte of the human that produces an autologous antibody to GPVI is activated by in vitro immunization under specific conditions; a hybridoma with mouse myeloma cell is prepared; and then the hybridoma that produces a monoclonal antibody, which has a binding capacity to GPVI and has an activity that suppresses collagen-mediated agglutinability of the human platelet is selected.
    Type: Application
    Filed: July 20, 2004
    Publication date: February 1, 2007
    Applicant: MOCHIDA PHARMACEUTICAL CO., LTD
    Inventors: Hiroshi Takayama, Kamon Shirakawa, Toru Yamakawa, Tetsushi Kawahara