Abstract: Provided is a pharmaceutical composition suitable for administration of anticancer drugs into lymph nodes by means of lymphatic drug delivery systems. A pharmaceutical composition for therapeutic or prophylactic treatment of cancer to be administered into lymph nodes, comprising at least one anticancer drug selected from the group consisting of antimetabolites and anticancer plant alkaloids as an active ingredient.

Abstract: Provided is a pharmaceutical composition suitable for administration of anticancer drugs into lymph nodes by means of lymphatic drug delivery systems. A pharmaceutical composition for therapeutic or prophylactic treatment of cancer to be administered into lymph nodes, comprising at least one anticancer drug selected from the group consisting of antimetabolites and anticancer plant alkaloids as an active ingredient.

Abstract: An electrode orientation checking apparatus includes a machine stand attached to a seam welding apparatus from which one roller electrode of a set has been removed, a positioning guide and a set of distance sensors that are provided on the machine stand, and a calculating section. A positioning surface of the positioning guide is fixed at a position corresponding to a portion of an outer circumferential surface of the one roller electrode before being removed, the portion lying on a line segment connecting rotational centers of the roller electrodes. The distance sensors are respectively fixed forward and backward of the positioning surface in a progression direction of the roller electrodes. The calculating section calculates data for acquiring a direction of the line segment relative to the stacked body.

Abstract: Provided is a shaping device for a roller electrode for seam welding that prepares shapes for a first roller electrode and a second roller electrode attached to an arm of a robot. This shaping device is provided independently from the robot and disposed within rotational range of the arm, and is provided with a first roller and a second roller that are disposed on a line orthogonal to a line joining the rotational centers of the first and second roller electrodes and are in contact with the outer circumferences of the first and second roller electrodes.

Abstract: An electrode orientation checking apparatus includes a machine stand attached to a seam welding apparatus from which one roller electrode of a set has been removed, a positioning guide and a set of distance sensors that are provided on the machine stand, and a calculating section. A positioning surface of the positioning guide is fixed at a position corresponding to a portion of an outer circumferential surface of the one roller electrode before being removed, the portion lying on a line segment connecting rotational centers of the roller electrodes. The distance sensors are respectively fixed forward and backward of the positioning surface in a progression direction of the roller electrodes. The calculating section calculates data for acquiring a direction of the line segment relative to the stacked body.

Abstract: Provided is an optimal intralymphatic preparation containing agents such as a drug, a cell, or a nucleic acid for use in a lymphatic drug delivery system. A drug-containing liquid preparation for delivering a chemical to a target lymph node by a lymphatic drug delivery system, wherein the liquid has an osmotic pressure of 700 to 2,700 kPa.

Abstract: Provided is a pharmaceutical composition suitable for administration of anticancer drugs into lymph nodes by means of lymphatic drug delivery systems. A pharmaceutical composition for therapeutic or prophylactic treatment of cancer to be administered into lymph nodes, comprising at least one anticancer drug selected from the group consisting of antimetabolites and anticancer plant alkaloids as an active ingredient.

Abstract: A laminate formed by stacking a plurality of workpieces is sandwiched between a pair of roller electrodes. Then, seam welding is performed on the laminate by successively repeating an ON/OFF operation of a conduction state between the pair of roller electrodes while moving the laminate relative to the pair of roller electrodes. When the seam welding stops in a state where the pair of roller electrodes are unpowered and then the seam welding is to be resumed, the laminate is moved by a predetermined distance in a direction opposite to the relative moving direction during seam welding, spot welding is performed on the laminate, and then the seam welding is resumed.

Abstract: Provided is a shaping device for a roller electrode for seam welding that prepares shapes for a first roller electrode and a second roller electrode attached to an arm of a robot. This shaping device is provided independently from the robot and disposed within rotational range of the arm, and is provided with a first roller and a second roller that are disposed on a line orthogonal to a line joining the rotational centers of the first and second roller electrodes and are in contact with the outer circumferences of the first and second roller electrodes.

Abstract: A magnetic field is generated in a workpiece in a direction orthogonal to the joining direction, and as a result of the Lorentz force resulting from the magnetic field and the current between the plasma torch and the workpiece, the front tip side of the arc is bent forward in the direction of advancement of the plasma torch and welding is performed. The magnetic field strength of the welded part is adjusted by changing the relative positions of the plasma torch and a butting portion of the workpiece.

Abstract: It is an object of the present invention to provide a novel molecule for antisense therapies which is not susceptible to nuclease degradation in vivo and has a high binding affinity and specificity for the target mRNAs and which can efficiently regulate expression of specific genes. The novel artificial nucleoside of the present invention has an amide bond introduced into a bridge structure of 2?,4?-BNA/LNA. The oligonucleotide containing the 2?,4?-bridged artificial nucleotide has a binding affinity for a single-stranded RNA comparable to known 2?,4?-BNA/LNA and has an increased nuclease resistance over LNA. Particularly, it is expected to be applied to nucleic acid drugs because of its much stronger binding affinity for single-stranded RNAs than S-oligo's affinity.

Abstract: A magnetic field is generated in a workpiece in a direction orthogonal to the joining direction, and as a result of the Lorentz force resulting from the magnetic field and the current between the plasma torch and the workpiece, the front tip side of the arc is bent forward in the direction of advancement of the plasma torch and welding is performed. The magnetic field strength of the welded part is adjusted by changing the relative positions of the plasma torch and a butting portion of the workpiece.

Abstract: A two-electrode arc welding device and two-electrode arc welding method are provided for performing welding with improved penetration performance using two non-consumable electrodes. In a two-electrode arc welding device, a power-supply unit outputs a straight-polarity voltage and a reverse-polarity voltage, which has a different electrical potential than the straight-polarity voltage. The straight-polarity voltage output from the power-supply unit is applied to a non-consumable electrode of a straight-polarity arc torch, whereby an arc is formed. The reverse-polarity voltage output from the power-supply unit is applied to a non-consumable electrode of a straight-polarity arc torch, whereby an arc is formed. An arc spacing distance, which is a distance between the ends of both the straight-polarity arc torch and the reverse-polarity arc torch, is set to be at least a minimum distance at which an arc will not occur therebetween (arc spacing critical distance).

Abstract: It is an object of the present invention to provide a novel molecule for antisense therapies which is not susceptible to nuclease degradation in vivo and has a high binding affinity and specificity for the target mRNAs and which can efficiently regulate expression of specific genes. The novel artificial nucleoside of the present invention has an amide bond introduced into a bridge structure of 2?,4?-BNA/LNA. The oligonucleotide containing the 2?,4?-bridged artificial nucleotide has a binding affinity for a single-stranded RNA comparable to known 2?,4?-BNA/LNA and has an increased nuclease resistance over LNA.

Abstract: A motor control apparatus includes a steering column having inserted therein a steering shaft to which steering torque is transmitted, a reduction gear box coupled to the steering shaft, and an electric motor that transmits a steering assisting force to the steering shaft via a reduction mechanism in the reduction gear box. The electric motor and its control unit including a control board mounted with a control circuit, are provided side by side in the reduction gear box. A connection terminal of the electric motor is electrically connected to the control unit directly. This minimizes a connection distance between the control unit and the electric motor.

Abstract: A two-electrode arc welding device and two-electrode arc welding method are provided for performing welding with improved penetration performance using two non-consumable electrodes. In a two-electrode arc welding device 1, a power-supply unit 11 outputs a straight-polarity voltage and a reverse-polarity voltage, which has a different electrical potential than the straight-polarity voltage. The straight-polarity voltage output from the power-supply unit 11 is applied to a non-consumable electrode 41 of a straight-polarity arc torch 14, whereby an arc is formed. The reverse-polarity voltage output from the power-supply unit 11 is applied to a non-consumable electrode 41 of a straight-polarity arc torch 15, whereby an arc is formed. An arc spacing distance L1, which is a distance between the ends of both the straight-polarity arc torch 14 and the reverse-polarity arc torch 15, is set to be at least a minimum distance at which an arc will not occur therebetween (arc spacing critical distance).

Abstract: To provide an electric power steering apparatus in which it is possible to reduce a size of the entire structure of a control unit while sufficiently showing a heat radiation effect of heat generating members. The electric power steering apparatus includes a steering column 3 having inserted therein a steering shaft 2 to which steering torque is transmitted, a reduction gear box 4 coupled to the steering shaft 2, and an electric motor 5 that transmits a steering assisting force to the steering shaft 2 via a reduction mechanism in the reduction gear box. In the reduction gear box 4, a motor mounting section 17 for mounting the electric motor 5 is formed at an end face in a direction perpendicular to an axis of the steering shaft 2 and a control-unit mounting section 20 for mounting a control unit 19 for controlling to drive the electric motor 5 is formed near the motor mounting section 17.

Abstract: To provide an electric power steering apparatus in which it is possible to minimize a connection distance between a control unit and an electric motor and surely prevent electric noise from mixing between the control unit and the electric motor as well as to minimize electric resistance and minimize an electric loss by directly connecting the control unit and connection terminals of the electric motor and a torque sensor. A motor control apparatus includes a steering column 3 having inserted therein a steering shaft 2 to which steering torque is transmitted, a reduction gear box 4 coupled to the steering shaft 2, and an electric motor 5 that transmits a steering assisting force to the steering shaft 2 via a reduction mechanism in the reduction gear box 4.

Abstract: To provide an electric power steering apparatus in which it is possible to reduce a size of the entire structure of a control unit while sufficiently showing a heat radiation effect of heat generating members. The electric power steering apparatus includes a steering column 3 having inserted therein a steering shaft 2 to which steering torque is transmitted, a reduction gear box 4 coupled to the steering shaft 2, and an electric motor 5 that transmits a steering assisting force to the steering shaft 2 via a reduction mechanism in the reduction gear box. In the reduction gear box 4, a motor mounting section 17 for mounting the electric motor 5 is formed at an end face in a direction perpendicular to an axis of the steering shaft 2 and a control-unit mounting section 20 for mounting a control unit 19 for controlling to drive the electric motor 5 is formed near the motor mounting section 17.