Patents by Inventor Tetsuya Okutani

Tetsuya Okutani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycerol derivatives, their production and use
    Patent number: 4889953
    Abstract: Compounds of the formula: ##STR1## wherein R.sup.1 is a higher alkyl group which may be substituted; R.sup.2 is a hydrogen, a lower alkyl group which may be substituted, a lower alkanoyl group which may be substituted or a lower alkylthiocarbamoyl group; R.sup.3 is a primary to tertiary amino group or a quaternary ammonium group; and n is 2 or 3, and salts thereof, have antitumor activity and platelet activating factor inhibitory activity.
    Type: Grant
    Filed: July 22, 1987
    Date of Patent: December 26, 1989
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Keizo Inoue, Hiroaki Nomura, Tetsuya Okutani
  • Phospholipid derivatives
    Patent number: 4778912
    Abstract: Phospholipid derivatives of the formula: ##STR1## wherein R.sup.1 is a higher alkyl, acylmethyl or alkylcarbamoyl group which may be substituted by cycloalkyl; R.sup.2 is a lower alkyl which may be substituted by carboxy, formyl or lower acyl, a carbamoyl or thiocarbamoyl group which is substituted by lower alkyl, or an acetoacetyl group; R.sup.3, R.sup.4 and R.sup.5 are independently hydrogen or lower alkyl, or ##STR2## represents a cyclic ammonio group; and n represents an integer of 8 to 14, and salts thereof have antitumor activity.
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: October 18, 1988
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Keizo Inoue, Hiroaki Normura, Tetsuya Okutani
  • 2-(acetoacetyloxy)-3-(octadecyloxy)propyl-3-trimethylammoniopropyl phosphate or a pharmaceutically acceptable salt thereof
    Patent number: 4710579
    Abstract: A compound provided by the present invention, of the formula ##STR1## wherein R.sup.1 is C.sub.14-20 alkyl; R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen or C.sub.1-5 alkyl, or ##STR2## represents a cyclic ammonio group; and A is C.sub.2-5 alkylene, and a pharmaceutically acceptable salt thereof, are useful as a anti-tumor agent.
    Type: Grant
    Filed: October 30, 1985
    Date of Patent: December 1, 1987
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Shoshichi Nojima, Hiroaki Nomura, Tetsuya Okutani
  • 2-alkanoyloxy-3-(N-octadecylcarbamoyloxy)propyl 2-trimethylaminoethyl phosphate
    Patent number: 4675430
    Abstract: 2-Alkanoyloxy-3-(N-octadecylcarbamoyloxy)propyl trimethylammonioethyl phosphates and a salt thereof exhibit inhibitory activity against multiplication of tumor cells, and are useful as an antitumor agent.
    Type: Grant
    Filed: June 18, 1986
    Date of Patent: June 23, 1987
    Assignee: Takeda Chemical Industries, Inc.
    Inventors: Keizo Inoue, Hiroaki Nomura, Tetsuya Okutani
  • Quinone derivatives
    Patent number: 4559177
    Abstract: A compound of the formula: ##STR1## wherein m is an integer of 11 to 22; R.sub.1 is alkyl having 1 to 4 carbon atoms; R.sub.2 is hydrogen, alkyl having 1 to 4 carbon atoms or carboxylic acyl having 1 to 8 carbon atoms. Such compounds have pharmaceutical activities such as hypotensive, tissue metabolism stimulating, immuno-regulatory and lysosomal membrane stabilizing activity, and inhibit SRS-A production, and are useful as a heart failure remedy, cerebral circulation disturbance remedy, immuno-regulator, and antiallergic drug.
    Type: Grant
    Filed: June 30, 1980
    Date of Patent: December 17, 1985
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Tetsuya Okutani, Giichi Goto
  • Hexahydrodioxopyrimidines, their production and use
    Patent number: 4536504
    Abstract: Novel compounds of the formula: ##STR1## wherein R.sup.1 is lower alkyl; R.sup.2 is hydrogen or lower alkyl, which are produced by reacting a compound of the formula: ##STR2## wherein R.sup.3 is hydrocarbon residue, with a compound of the formula: ##STR3## The novel compounds have antiviral and antibacterial activity, and are useful to prolong the life span of tumor-bearing warm-blooded animals.
    Type: Grant
    Filed: July 13, 1983
    Date of Patent: August 20, 1985
    Assignee: Takeda Chemical Industries, Ltd.
    Inventor: Tetsuya Okutani
  • Quinone carboxylic acids and ester derivatives
    Patent number: 4495104
    Abstract: A compound of the general formula ##STR1## wherein n is an integer of 10 to 21, inclusive; R is H or lower alkyl having 1 to 4 carbon atoms has pharmaceutical activities such as hypotensive, tissue metabolism stimulating, immuno-regulatory, lysosomal membrane stabilizing and SRS-A production inhibitory activities and is useful as a heart failure remedy, cerebral circulation disturbance remedy, immuno-regulator, and antiallergic drug.
    Type: Grant
    Filed: July 11, 1980
    Date of Patent: January 22, 1985
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Isuke Imada, Tetsuya Okutani, Masazumi Watanabe
  • Dehydroxylation of aminosugars
    Patent number: 4029883
    Abstract: Dehydroxylation of aminoglycoside antibiotics is carried out by halogenation of phosphorylated aminoglycoside antibiotics followed by reduction of thus halogenated antibiotics. The dehydroxylation process is entirely new and gives the final product in a high yield. The resulting deoxyaminoglycoside antibiotics are effective against microorganisms including aminoglycoside antiobiotics-resistant microorganisms.
    Type: Grant
    Filed: December 20, 1973
    Date of Patent: June 14, 1977
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Kentaro Hiraga, Tetsuya Okutani, Kouichi Yoshioka, Tsunehiko Asako
  • Epiminodeaminodeoxyaminoglycoside antibiotics and intermediates
    Patent number: 4020269
    Abstract: Deoxyaminoglycoside antibiotics are prepared in a high yield from phosphorylated aminoglycosides by reacting a phosphorylated aminoglycoside (a) with a silylating agent, or (b) successively with (i) a silylating or acylating agent and (ii) a halogenating agent; then subjecting thus obtained intermediate to reduction. Deoxyaminoglycoside antibiotics are useful for treating infections caused by microorganisms which are resistant or non-resistant to the corresponding aminoglycoside antibiotics.
    Type: Grant
    Filed: April 8, 1975
    Date of Patent: April 26, 1977
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Kentaro Hiraga, Tetsuya Okutani, Tsunehiko Asako, Kouichi Yoshioka