Abstract: A method for treating Crohn's Disease in a subject in need thereof is provided. The method includes administering rectally to the subject a therapeutically effective amount of a composition comprising roflumilast. The composition may be administered repetitively over a period of days and may contain or be co-administered with one or more agents different from roflumilast that are directed against bowel disease. A suppository dosage form comprising roflumilast and a pharmaceutically acceptable carrier are also provided.

Abstract: A two-step process for the oligomerization and hydration of a mixed butenes feed is provided and is implemented in a two-stage system. The two-step process yields a product consisting of diisobutenes (DIBs) and mixed butanols. The DIBs are produced via the selective oligomerization of isobutene in a first stage and the mixed butanols are produced via the hydration, in a second stage, of mixed butenes that remain unreacted in the first stage.

Abstract: A process for simultaneously hydrating and oligomerizing a hydrocarbon feed comprising mixed olefins incudes the steps of: (a) introducing the hydrocarbon feed in the presence of water into a fixed bed; (b) contacting the hydrocarbon feed with a catalyst within said fixed bed reactor, where the catalyst is of the type that hydrates the mixed olefins to form mixed alcohols and oligomerizes at least a portion of the mixed olefins into oligomers to produce a first product stream that includes an organic phase and an aqueous phase; (c) introducing the first product stream into a first separator which separates the organic phase from the aqueous phase; (d) introducing the separated organic phase into a second separator which separates unreacted olefins from mixed alcohols and one or more oligomers which comprise a final product stream; and (e) introducing the separated aqueous phase into a third separator which separates an alcohol-water azeotrope component from water.

Abstract: A two-step process for the oligomerization and hydration of a mixed butenes feed is provided and is implemented in a two-stage system. The two-step process yields a product consisting of diisobutenes (DIBs) and mixed butanols. The DIBs are produced via the selective oligomerization of isobutene in a first stage and the mixed butanols are produced via the hydration, in a second stage, of mixed butenes that remain unreacted in the first stage.

Abstract: A two-step process for the oligomerization and hydration of a mixed butenes feed is provided and is implemented in a two-stage system. The two-step process yields a product consisting of diisobutenes (DIBs) and mixed butanols. The DIBs are produced via the selective oligomerization of isobutene in a first stage and the mixed butanols are produced via the hydration, in a second stage, of mixed butenes that remain unreacted in the first stage.

Abstract: A process for simultaneously hydrating and oligomerizing a hydrocarbon feed comprising mixed olefins incudes the steps of: (a) introducing the hydrocarbon feed in the presence of water into a fixed bed; (b) contacting the hydrocarbon feed with a catalyst within said fixed bed reactor, where the catalyst is of the type that hydrates the mixed olefins to form mixed alcohols and oligomerizes at least a portion of the mixed olefins into oligomers to produce a first product stream that includes an organic phase and an aqueous phase; (c) introducing the first product stream into a first separator which separates the organic phase from the aqueous phase; (d) introducing the separated organic phase into a second separator which separates unreacted olefins from mixed alcohols and one or more oligomers which comprise a final product stream; and (e) introducing the separated aqueous phase into a third separator which separates an alcohol-water azeotrope component from water.

Abstract: A two-step process for the oligomerization and hydration of a mixed butenes feed is provided and is implemented in a two-stage system. The two-step process yields a product consisting of diisobutenes (DIBs) and mixed butanols. The DIBs are produced via the selective oligomerization of isobutene in a first stage and the mixed butanols are produced via the hydration, in a second stage, of mixed butenes that remain unreacted in the first stage.