Patents by Inventor Thangavel Arulmoli
Thangavel Arulmoli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8759513Abstract: The present invention discloses a stable amorphous form of Rifaximin characterized by having X-ray powder diffraction pattern as given in FIG. 1, having a 2? peaks at 7.2 and having moisture content in the range of 3% to 4% preferably, 3.4% to 3.7%. This invention also discloses a novel process for its preparation.Type: GrantFiled: August 24, 2011Date of Patent: June 24, 2014Assignee: Sequent Scientific LimitedInventors: Sumangala Venkatramana, Vijesh Alanthatta Madathil, Pejala Kakrannaya Vasudeva, Thangavel Arulmoli
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Patent number: 8754215Abstract: The present disclosure describes a novel, cost-effective process for preparation of a 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2,1-a]isoquinoline derivatives. Specifically, it discloses a process for the preparation of the anthelmintic drug praziquantel through the use of a novel intermediate, 2-[(2,2-dimethoxyethyl)benzyl amino]-N-phenethylacetamide. This present disclosure also describes a novel crystalline form of 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.Type: GrantFiled: June 12, 2013Date of Patent: June 17, 2014Assignee: Sequent Scientific LimitedInventors: Lingappa Balaya, Mahalinga Manjathuru, Yogeesh Derambala, Pejakala Kakrannaya Vasudeva, Thangavel Arulmoli
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Publication number: 20140100385Abstract: The present invention relates to a process for the preparation of succinylcholine chloride, a pharmaceutically active compound used as skeletal muscle relaxant which comprises condensing succinic anhydride with N,N-diemthylaminoethanol using a catalyst in presence of a solvent to form bis[2-(dimethylamino)ethyl]succinate; in situ purifying the bis[2-(dimethylamino)ethyl]succinate using a base; reacting pure bis[2-(dimethylamino)ethyl]succinate with methyl chloride gas using an alcohol; and purifying the obtained crude succinylcholine chloride using water and alcohol.Type: ApplicationFiled: February 20, 2013Publication date: April 10, 2014Applicant: SEQUENT SCIENTIFIC LIMITEDInventors: Mahalinga MANJATHURU, Anil Narayan MAYEKAR, Pejakala Kakrannaya VASUDEVA, Thangavel ARULMOLI, Gautam Kumar DAS
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Publication number: 20140012001Abstract: The present invention discloses a stable amorphous form of Rifaximin characterised by having X-ray powder diffraction pattern as given in FIG. 1, having a 2? peaks at 7.2 and having moisture content in the range of 3% to 4% preferably, 3.4% to 3.7%. This invention also discloses a novel process for its preparation.Type: ApplicationFiled: August 24, 2011Publication date: January 9, 2014Applicant: SEQUENT SCIENTIFIC LTD.Inventors: Sumangala Venkatramana, Vjesh Alanthatta Madathil, Pejakala Kakrannaya Vasudeva, Thangavel Arulmoli
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Publication number: 20130303782Abstract: The present invention discloses a novel, cost-effective process for preparation of a benzimidazole carbamates compound. Specifically, it relates to the process for the preparation of anti-parasite bulk drug albendazole. The process comprises a) thiocyanating 2-nitroaniline of formula VI with ammonium thiocyanated in presence of a halogen to obtain 2-nitro-4-thiocyanoaniline of formula V; b)propylating 2-nitro-4-thiocyanoaniline of formula V with propylbromide in presence of n-propanol and a base in absence of a phase transfer catalyst to obtain 4-propylthio-2-nitroaniline of formula III; C) reducing the nitro group of 4-propylthio-2-nitroaniline prepared in step b) by reacting an aqueous alkali metal sulphide or an alkaline metal sulphide to obtain 4-propylthio-o-phenylenediamine of formula II; and d)condensing 4-propylthio-o-phenylenediamine of formula II with alkali or alkaline earth metal salt of methylcyano carbamate in presence of an acid to form Albendazole of formula I.Type: ApplicationFiled: November 23, 2011Publication date: November 14, 2013Applicant: SEQUENT SCIENTIFIC LIMITEDInventors: Ramkrishna Appaji Rane, Sushil Naithani, Rajendra Devendra Natikar, Sudhakar Verma, Thangavel Arulmoli
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Publication number: 20130303781Abstract: The present invention discloses a method for preparing Triclabendazole comprising condensing N-(4,5-dichloro-2-ni-trophenyl)acetamide with 2,3-dichlorophenol to obtain 4-chloro-5(2,3-dichlorophenoxy)-2-nitrophenyl acetamide and it to obtain 4-chloro-5(2,3-dichlorophenoxy)-2-nitroaniline; reducing 4-chloro-5(2,3-dichlorophenoxy)-2-nitroaniline in presence of Raney nickel to obtain 4-chloro-5-(2,3-dichlorophenoxy)benzene-1,2-diamine of; cyclising 4-chloro-5-(2,3-dichlorophenoxy)benzene-1,2-diamine in presence of carbondisulfide to obtain 6-chloro-5-(2,3-dichlorophenoxy)-1H-benzimidazole-2-thiol; methylating 6-chloro-5-(2,3-dichlorophenoxy)-1H-benzimidazole-2-thiol using a methylating agent to obtain triclabendazole methanesulfonate salt; converting triclabendazole methanesulfonate salt to hydrochloride salt of Triclabendazole and hydrolysing it to obtain Triclabendazole.Type: ApplicationFiled: November 23, 2011Publication date: November 14, 2013Applicant: SEQUENT SCIENTIFIC LIMITEDInventors: Ramkrishna Appaji Rane, Sudhakar Verma, Thangavel Arulmoli
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Publication number: 20130289275Abstract: The present disclosure describes a novel, cost-effective process for preparation of a 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2,1-a]isoquinoline derivatives. Specifically, it discloses a process for the preparation of the anthelmintic drug praziquantel through the use of a novel intermediate, 2-[(2,2-dimethoxyethyl)benzyl amino]-N-phenethylacetamide. This present disclosure also describes a novel crystalline form of 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.Type: ApplicationFiled: June 12, 2013Publication date: October 31, 2013Inventors: Lingappa BALAYA, Mahalinga MANJATHURU, Yogeesh DERAMBALA, Pejakala Kakrannaya VASUDEVA, Thangavel ARULMOLI
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Patent number: 8129536Abstract: The present invention relates to an improved process for the preparation of Lansoprazole of formula (I). More particularly, the present invention relates to a method for the purification of crude Lansoprazole in a solvent in presence of an alkali salt of an organic acid or in presence of an organic base such as piperidine or imidazole.Type: GrantFiled: September 21, 2007Date of Patent: March 6, 2012Assignee: Orchid Chemicals & Pharmaceuticals LimitedInventors: Thangavel Arulmoli, Siripragada Mahender Rao, Krishna Sumanth Peraka, Ariyamuthu Sundara Selvan
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Publication number: 20100010230Abstract: The present invention relates to an improved process for the preparation of Lansoprazole of formula (I). More particularly, the present invention relates to a method for the purification of crude Lansoprazole in a solvent in presence of an alkali salt of an organic acid or in presence of an organic base such as piperidine or imidazole.Type: ApplicationFiled: September 21, 2007Publication date: January 14, 2010Applicant: Orchid Chemicals & Pharmaceuticals LimitedInventors: Thangavel Arulmoli, Siripragada Mahender Rao, Krishna Sumanth Peraka, Ariyamuthu Sundara Selvan
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Patent number: 7361761Abstract: The present invention is to relate an improved process using anisole as solvent for the preparation of compound of formula (I) and its pharmaceutically acceptable salts thereof. wherein R represents —NR1R2, or a group n=1, 2, 3, 4 and 5, where R1 and R2 may be same or different and independently represents hydrogen, or C1-6 alkyl.Type: GrantFiled: September 19, 2006Date of Patent: April 22, 2008Assignee: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Udayampalayam P. Senthilkumar, Thangavel Arulmoli, Venu S. Lakshmipathi, Siripragada M. Rao
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Publication number: 20070066569Abstract: The present invention is to relate an improved process using anisole as solvent for the preparation of compound of formula (I) and its pharmaceutically acceptable salts thereof.Type: ApplicationFiled: September 19, 2006Publication date: March 22, 2007Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LTD.Inventors: Udayampalayam Senthilkumar, Thangavel Arulmoli, Venu Lakshmipathi, Siripragada Rao