Patents by Inventor Thangavel Arunachalam

Thangavel Arunachalam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
    Patent number: 7399460
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the ?, ?, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: July 15, 2008
    Assignee: Bracco International B.V.
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Nataranjan Raju, Michael F. Tweedle
  • Metal Complexes Derivatized with Folate for use in Diagnostic and Therapeutic Applications
    Publication number: 20070077197
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the ?, ?, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Application
    Filed: September 25, 2006
    Publication date: April 5, 2007
    Applicant: Bracco International B.V.
    Inventors: Paul Wedeking, Ruth Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen Linder, Ramachandran Ranganathan, Adrian Nunn, Nataranjan Raju, Michael Tweedle
  • Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
    Patent number: 7186397
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the ?, ?, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Grant
    Filed: December 30, 2000
    Date of Patent: March 6, 2007
    Assignee: Bracco International B.V.
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
  • N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for x-ray CT imaging
    Patent number: 6264916
    Abstract: Compounds having formulae I, II or/III, or pharmaceutically acceptable salts thereof, R1, R2, R3, R4, R5, R6, R7 and R8 are the same or different and are hydrogen, alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, haloalkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or carboxamido alkyl with the proviso that in formula I R2 and R3 cannot be methyl; and m, n and p are the same or different and are 0-24 with the proviso that m+n≦24, are useful as contrast agents in x-ray imaging compositions and methods.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: July 24, 2001
    Assignee: Bracco Research, USA
    Inventors: Rama S. Ranganathan, Thangavel Arunachalam, Michael F. Tweedle
  • Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
    Publication number: 20010004454
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Application
    Filed: December 30, 2000
    Publication date: June 21, 2001
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
  • Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
    Patent number: 6221334
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Grant
    Filed: January 3, 2000
    Date of Patent: April 24, 2001
    Assignee: Bracco Research USA, Inc.
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
  • Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
    Patent number: 6093382
    Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.
    Type: Grant
    Filed: May 16, 1998
    Date of Patent: July 25, 2000
    Assignee: Bracco Research USA Inc.
    Inventors: Paul W. Wedeking, Ruth E. Wager, Thangavel Arunachalam, Kondareddiar Ramalingam, Karen E. Linder, Ramachandran S. Ranganathan, Adrian D. Nunn, Natarajan Raju, Michael F. Tweedle
  • N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for X-ray CT imaging
    Patent number: 6051210
    Abstract: Compounds having formulae I, II or III, or pharmaceutically acceptable salts thereof, ##STR1## wherein ##STR2## R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are the same or different and are hydrogen, alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, haloalkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or carboxamido alkyl with the proviso that in formula I R.sub.2 and R.sub.3 cannot be methyl; andm, n and p are the same or different and are 0-24 with the proviso that m+n.ltoreq.24, are useful as contrast agents in x-ray imaging compositions and methods.
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: April 18, 2000
    Assignee: Bracco Research USA
    Inventors: Rama S. Ranganathan, Thangavel Arunachalam, Michael F. Tweedle
  • Process for preparation of 2-oxo-1-piperidinyl derivatives
    Patent number: 5559237
    Abstract: The present process involves ring opening and ring closure of compounds containing a tetrahydrofuroyl ##STR1## to provide facile synthesis of compounds containing a piperidin-2-one group of the formula ##STR2##
    Type: Grant
    Filed: July 15, 1994
    Date of Patent: September 24, 1996
    Assignee: Bracco International B.V.
    Inventors: Ramachandran S. Ranganathan, Thangavel Arunachalam, Kenneth J. Natalie, Jr.
  • Process for preparation of 2-oxo-1 piperidinyl derivatives
    Patent number: 5359077
    Abstract: The process involves ring opening and ring closure of compounds containing a tetrahydrofuroyl group ##STR1## to provide facile synthesis of compounds containing a piperidin-2-one group of the formula ##STR2##
    Type: Grant
    Filed: June 5, 1992
    Date of Patent: October 25, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ramachandran S. Ranganathan, Thangavel Arunachalam, Kenneth J. Natalie, Jr
  • Nonionic radiographic contrast agents
    Patent number: 5278311
    Abstract: Novel nonionic contrast agents of the formula ##STR1## or dimers of the formula ##STR2## are disclosed where X, Z and R.sub.1 -R.sub.5 are as defined herein.
    Type: Grant
    Filed: June 5, 1992
    Date of Patent: January 11, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Thangavel Arunachalam, Ramachandran Ranganathan