Patents by Inventor Thayne L. Edwards
Thayne L. Edwards has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11554369Abstract: The present invention relates to encapsulated microfluidic packages and methods thereof. In particular embodiments, the package includes a device, a cradle configured to support the device, and a lid having a bonding surface configured to provide a fluidic seal between itself and the device and/or cradle. Other package configurations, as well as methods for making such fluidic seals, are described herein.Type: GrantFiled: May 27, 2020Date of Patent: January 17, 2023Assignee: National Technology & Engineering Solutions of Sandia, LLCInventors: Darren W. Branch, Philip R. Miller, Thayne L. Edwards, David R. Wheeler
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Patent number: 11378576Abstract: Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents.Type: GrantFiled: February 15, 2019Date of Patent: July 5, 2022Assignees: UNM Rainforest Innovations, National Technology & Engineering Solutions of Sandia, LLCInventors: Richard S. Larson, Brian Hjelle, David C. Brown, Marco Bisoffi, Susan M. Brozik, Darren W. Branch, Thayne L. Edwards, David Wheeler
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Publication number: 20220151516Abstract: Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.Type: ApplicationFiled: February 4, 2022Publication date: May 19, 2022Inventors: Joseph Wang, Joshua Ray Windmiller, Roger Narayan, Phillip Miller, Ronen Polsky, Thayne L. Edwards
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Patent number: 11209394Abstract: A cartridge for sample handling and sensing includes (i) a sample port; (ii) a first fluid port connected to the sample reservoir in the distal region via a first fluid channel; and (iii) a second fluid port connected to the sample reservoir via a second fluid channel. The cartridge includes (i) a sensor platform comprising a bulk acoustic wave (BAW) resonator and a fluid flow path comprising a sensing region extending across a sensing surface of the BAW resonator; and (ii) a fluid valve between the sample reservoir and the sensing region. A sample may be applied to the sample port; first volume of fluid may be injected through the first fluid port; and then a second volume of fluid may be injected through the second fluid port to drive the sample into the sensing region of the fluid flow path.Type: GrantFiled: July 26, 2017Date of Patent: December 28, 2021Assignee: Qorvo US, Inc.Inventors: Thayne L. Edwards, Florian Bell, Matthew Ryder, Bruce Murdock
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Publication number: 20210138461Abstract: A sampler for acquiring and transporting sample material may include a sampler body defining a sampling volume configured to hold the sample material. The sampler body may define a sample port that may be used as an entrance to collect the sample material and an exit to expel the sample material. The sample port may be configured to be operably connected to a fluidic channel of a cartridge. The sampler may also define a pump connection port configured to be operably connected to a pump. The pump may force the sample material out of the sampling volume through the sample port.Type: ApplicationFiled: August 2, 2017Publication date: May 13, 2021Inventors: Thayne L. Edwards, Florian Bell
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Patent number: 10974243Abstract: A sensor using electrophoresis may include a microfluidic channel and electrodes on opposite sides of the microfluidic channel to generate an electric field across, or normal to, the channel. The electric field may be used to drive charged particles of material, particularly material suspended in fluid in the microfluidic channel, toward or away from the one of the electrodes. The electric field may be modulated to allow material to continue flowing through the microfluidic channel, to remove non-target material, or to measure another target material.Type: GrantFiled: July 26, 2017Date of Patent: April 13, 2021Assignee: Qorvo US, Inc.Inventor: Thayne L. Edwards
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Publication number: 20200316596Abstract: The present invention relates to encapsulated microfluidic packages and methods thereof. In particular embodiments, the package includes a device, a cradle configured to support the device, and a lid having a bonding surface configured to provide a fluidic seal between itself and the device and/or cradle. Other package configurations, as well as methods for making such fluidic seals, are described herein.Type: ApplicationFiled: May 27, 2020Publication date: October 8, 2020Inventors: Darren W. Branch, Philip R. Miller, Thayne L. Edwards, David R. Wheeler
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Patent number: 10717079Abstract: The present invention relates to encapsulated microfluidic packages and methods thereof. In particular embodiments, the package includes a device, a cradle configured to support the device, and a lid having a bonding surface configured to provide a fluidic seal between itself and the device and/or cradle. Other package configurations, as well as methods for making such fluidic seals, are described herein.Type: GrantFiled: January 25, 2017Date of Patent: July 21, 2020Assignee: National Technology & Engineering Solutions of Sandia, LLCInventors: Darren W. Branch, Philip R. Miller, Thayne L. Edwards, David R. Wheeler
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Publication number: 20190329255Abstract: A sensor using electrophoresis may include a microfluidic channel and electrodes on opposite sides of the microfluidic channel to generate an electric field across, or normal to, the channel. The electric field may be used to drive charged particles of material, particularly material suspended in fluid in the microfluidic channel, toward or away from the one of the electrodes. The electric field may be modulated to allow material to continue flowing through the microfluidic channel, to remove non-target material, or to measure another target material.Type: ApplicationFiled: July 26, 2017Publication date: October 31, 2019Inventor: Thayne L. Edwards
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Publication number: 20190242888Abstract: Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents.Type: ApplicationFiled: February 15, 2019Publication date: August 8, 2019Inventors: Richard S. Larson, Brian Hjelle, Pam R. Hall, David C. Brown, Marco Bisoffi, Susan M. Brozik, Darren W. Branch, Thayne L. Edwards, David Wheeler
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Publication number: 20190234907Abstract: A cartridge for sample handling and sensing includes a sample port connected to a sample reservoir having a proximal end, a proximal region adjacent the proximal end, and a distal end opposite of the proximal end. The cartridge also includes a first fluid port connected to the sample reservoir in the distal region via a first fluid channel; and a second fluid port connected to the sample reservoir in the proximal region via a second fluid channel. In addition, the cartridge includes a sensor platform comprising a bulk acoustic wave (BAW) resonator and a fluid flow path comprising a sensing region extending across a sensing surface of the BAW resonator. The cartridge further includes a fluid valve between the distal end of the sample reservoir and the sensing region.Type: ApplicationFiled: July 26, 2017Publication date: August 1, 2019Inventors: Thayne L. Edwards, Florian Bell, Matthew Ryder, Bruce Murdock
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Publication number: 20190125223Abstract: Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.Type: ApplicationFiled: October 24, 2018Publication date: May 2, 2019Inventors: Joseph Wang, Joshua Ray Windmiller, Roger Narayan, Phillip Miller, Ronen Polsky, Thayne L. Edwards
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Patent number: 10261078Abstract: The present application relates to a biosensor that employs an acoustic cavity to store mechanical energy. In particular examples, the biosensor includes an electrode region and one or more reflector regions to form the acoustic cavity, as well as a functionalized active area disposed in proximity to the cavity. Methods of making and using such biosensors are also described herein.Type: GrantFiled: August 16, 2016Date of Patent: April 16, 2019Assignee: National Technology & Engineering Solutions of Sandia, LLCInventors: Darren W. Branch, Thayne L. Edwards
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Publication number: 20180338713Abstract: The present invention is directed to devices and methods for detecting one or more markers in a sample. In particular, such devices integrate a plurality of hollow needles configured to extract or obtain a fluid sample from a subject, as well as transducers to detect a marker of interest (e.g., an electrolyte). In some embodiments, the needles are provided as a disposable cartridge.Type: ApplicationFiled: November 11, 2014Publication date: November 29, 2018Inventors: Ronen Polsky, Philip Rocco Miller, Matthew W. Moorman, Susan M. Brozik, Ronald P. Manginell, David R. Wheeler, Thayne L. Edwards
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Patent number: 10136846Abstract: Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.Type: GrantFiled: August 25, 2017Date of Patent: November 27, 2018Assignees: The Regents of the University of California, North Carolina State University, National Technology & Engineering Solutions of Sandia, LLCInventors: Joseph Wang, Joshua Ray Windmiller, Roger Narayan, Phillip Miller, Ronen Polsky, Thayne L. Edwards
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Patent number: 10126299Abstract: The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.Type: GrantFiled: November 22, 2017Date of Patent: November 13, 2018Assignee: National Technology & Engineering Solutions of Sandia, LLCInventors: Jason C. Harper, Thayne L. Edwards, Bryan Carson, Melissa Finley, William Arndt
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Patent number: 10031135Abstract: Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents.Type: GrantFiled: February 4, 2014Date of Patent: July 24, 2018Assignees: STC.UNM, SANDIA CORPORATIONInventors: Richard S. Larson, Brian Hjelle, Pam R. Hall, David C. Brown, Marco Bisoffi, Susan M. Brozik, Darren W. Branch, Thayne L. Edwards, David Wheeler
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Patent number: 9995411Abstract: The present invention relates to adhesive-based microvalves, as well as assemblies and cartridges having such microvalves. In particular examples, substantially planar layers of adhesive materials are used to construct both normally-open and normally-closed microvalves for fluid control within microfluidic laminate cartridges. Such microvalves and cartridges can be useful for medical, chemical, and biological investigations.Type: GrantFiled: July 16, 2014Date of Patent: June 12, 2018Assignee: National Technology & Engineering Solutions of Sandia, LLCInventors: Matthew W. Moorman, Ronald P. Manginell, Thayne L. Edwards
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Patent number: 9987427Abstract: The present invention is directed to devices, systems, and methods for detecting and/or monitoring one or more markers in a sample. In particular, such devices integrate a plurality of hollow needles configured to extract or obtain a fluid sample from a subject, as well as transducers to detect a marker of interest.Type: GrantFiled: June 22, 2015Date of Patent: June 5, 2018Assignee: National Technology & Engineering Solutions of Sandia, LLCInventors: Ronen Polsky, Philip Rocco Miller, Thayne L. Edwards
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Publication number: 20180095083Abstract: The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.Type: ApplicationFiled: November 22, 2017Publication date: April 5, 2018Inventors: Jason C. Harper, Thayne L. Edwards, Bryan Carson, Melissa Finley, William Arndt