Patents by Inventor Theo Lasser
Theo Lasser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230250493Abstract: The present disclosure concerns a method for detecting and characterizing a virus comprising the steps of providing a sample to analyze that is likely to contain a virus, extracting and preparing nucleic acids from the sample, sequence-specifically labeling the nucleic acid, e.g. by introducing fluorophores by contacting the nucleic acid with a methyltransferase or by introducing fluorescently labelled nucleotides after treatment with nickase, performing a genomic mapping analysis of the extracted nucleic acids and performing a computational analysis to detect the presence of and characterise at least one virus. The present disclosure also concerns a kit for carrying out the above method.Type: ApplicationFiled: June 25, 2021Publication date: August 10, 2023Inventors: Volker LEEN, Theo LASSER, Johan HOFKENS, Jens H. GUNDLACH
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Patent number: 10617303Abstract: A functional optical coherent imaging (fOCI) platform includes at least one active camera unit (ACU) having a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD.Type: GrantFiled: July 28, 2017Date of Patent: April 14, 2020Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Theo Lasser, Dimitri Van De Ville, Erica Martin-Williams, Marcel Leutenegger, Iwan Maerki, Michael Friedrich, Martin Villiger
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Publication number: 20180098702Abstract: A functional optical coherent imaging (fOCI) platform includes at least one active camera unit (ACU) having a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit. SAU); and an operator interface (HOD.Type: ApplicationFiled: July 28, 2017Publication date: April 12, 2018Inventors: Theo LASSER, Dimitri VAN DE VILLE, Erica MARTIN-WILLIAMS, Marcel LEUTENEGGER, Iwan MAERKI, Michael FRIEDRICH, Martin VILLIGER
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Publication number: 20170360853Abstract: Pharmaceutical composition for the treatment of proteinopathies comprising products which are able to stimulate growth or inhibition of at least one of Odoribacter, Oscillospira, Dehalobacterium, Alistipes, Parabacteroides, Lactobacillus and Sutterella, Firmicutes, Bacteroidetes, Allobaculum and Akkermansia bacteria population in the gut of individuals.Type: ApplicationFiled: December 23, 2015Publication date: December 21, 2017Inventors: Theo Lasser, Tristan Bolmont, Taoufiq Harach, Walid Hanna, Frida Fåk, Nittaya Marungruang
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Patent number: 9791684Abstract: The invention relates to an optical coherence microscopy system for fast, phase resolved imaging by means of optical coherence microscopy with decoupled illumination and detection apertures, producing a dark-field effect with an enhanced optical contrast. The setup uses a light source with an appropriate temporal coherence, an interferometer and an array detector combined with a spectrometer. The dark-field effect is produced by optical filter means in the illumination and detection paths, positioned in conjugated planes of the sample microscope objective. These optical means comprise for example refractive or diffractive elements, amplitude or phase masks, or programmable spatial light modulators. The object is scanned via a scanning unit allowing a point scan of the object.Type: GrantFiled: January 4, 2011Date of Patent: October 17, 2017Assignee: Ecole Polytechnique Fédérale de Lausanne (EPFL)Inventors: Martin Villiger, Christophe Pache, Theo Lasser
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Patent number: 9757039Abstract: A functional optical coherent imaging (fOCI) platform includes at least one active camera unit (ACU) having a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD.Type: GrantFiled: June 29, 2015Date of Patent: September 12, 2017Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Theo Lasser, Dimitri Van De Ville, Erica Martin-Williams, Marcel Leutenegger, Iwan Maerki, Michael Friedrich, Martin Villiger
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Patent number: 9658442Abstract: The invention describes a method and a microscopy system for imaging and analyzing stochastically and independently blinking point-like emitters. A multiple-order cumulants analysis in conjunction with an established blinking model enables the extraction of super-resolved environment-related parameter maps, such as molecular state lifetimes, concentration and brightness distributions of the emitter. In addition, such parameter maps can be used to compensate for the non-linear brightness and blinking response of higher-order cumulant images—used for example in Super-resolution Optical Fluctuation Imaging (SOFI)—to generate a balanced image contrast. Structures that otherwise would be masked by brighter regions in the conventional cumulant image become samples using spectral cross-cumulants.Type: GrantFiled: March 31, 2012Date of Patent: May 23, 2017Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Stefan Geissbuehler, Claudio Dellagiacoma, Matthias Geissbuehler, Theo Lasser, Marcel Leutenegger
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Patent number: 9547004Abstract: A method and device for the rapid quantification of biomolecules (320) present in a nanochannel (210) is claimed. In particular, the present invention relates to a novel concept of liquid actuation and selectively functionalized surfaces in a nanochannel that create a concentration gradient of transitory immobilized biomolecules (340) across the nanochannel. The present concept enables the quantification of biomolecular interactions of interest (320).Type: GrantFiled: February 6, 2012Date of Patent: January 17, 2017Assignee: ABIONIC SAInventors: Nicolas Durand, Iwan Märki, Stéphane Broillet, Annick Mayor, Theo Lasser
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Publication number: 20160367145Abstract: A functional optical coherent imaging (fOCI) platform includes at least one active camera unit (ACU) having a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD.Type: ApplicationFiled: June 29, 2015Publication date: December 22, 2016Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Theo LASSER, Dimitri VAN DE VILLE, Erica MARTIN-WILLIAMS, Marcel LEUTENEGGER, Iwan MAERKI, Michael FRIEDRICH, Martin VILLIGER
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Patent number: 9452927Abstract: A method and device for the rapid detection of biomolecules (320) diffusing in a nanometer-confined slit (204) is claimed. In particular, the present invention relates to a novel concept of fluidic side apertures (205) that facilitates the filling of the device, the surface coating with biomolecules and that measures the affinity between fluorescently labeled biomolecules in aqueous solution with other biomolecules immobilized on surfaces.Type: GrantFiled: November 19, 2010Date of Patent: September 27, 2016Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Nicolas Durand, Yannick Fournier, Theo Lasser, Iwan Märki
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Patent number: 9066686Abstract: The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD.Type: GrantFiled: July 10, 2008Date of Patent: June 30, 2015Assignee: Novadaq Technologies Inc.Inventors: Theo Lasser, Dimitri Van De Ville, Erica Martin-Williams, Marcel Leutenegger, Iwan Maerki, Michael Friedrich, Martin Villiger
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Patent number: 8938103Abstract: A method and system for the rapid detection of biomolecular interactions, the system comprising a sensing platform which comprises a primary support structure including recesses designed to be located in front of a detection unit, said recesses containing one or several arrays of biosensors, said system furthermore comprising a reader unit for optical excitation and detection.Type: GrantFiled: February 25, 2011Date of Patent: January 20, 2015Assignee: Ecole Polytechnique Ferderale de Lausanne (EPFL)Inventors: Nicolas Durand, Iwan Märki, Theo Lasser
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Patent number: 8929974Abstract: In a system and a method for examining an object containing a fluid liquid, the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of hemoglobin, a concentration of hemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.Type: GrantFiled: April 8, 2010Date of Patent: January 6, 2015Assignee: Carl Zeiss Meditec AGInventors: Christoph Hauger, Werner Nahm, Theo Lasser, Marcel Leutenegger, Erica Martin-Williams, Antonio Lopez
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Publication number: 20140256573Abstract: A method and device for the rapid quantification of biomolecules (320) present in a nanochannel (210) is claimed. In particular, the present invention relates to a novel concept of liquid actuation and selectively functionalized surfaces in a nanochannel that create a concentration gradient of transitory immobilized biomolecules (340) across the nanochannel. The present concept enables the quantification of biomolecular interactions of interest (320).Type: ApplicationFiled: February 6, 2012Publication date: September 11, 2014Applicant: ABIONIC SAInventors: Nicolas Durand, Iwan Märki, Stéphane Broillet, Annick Mayor, Theo Lasser
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Publication number: 20140198198Abstract: The invention describes a method and a microscopy system for imaging and analysing stochastically and independently blinking point-like emitters. A multiple-order cumulants analysis in conjunction with an established blinking model enables the extraction of super-resolved environment-related parameter maps, such as molecular state lifetimes, concentration and brightness distributions of the emitter. In addition, such parameter maps can be used to compensate for the non-linear brightness and blinking response of higher-order cumulant images—used for example in Super-resolution Optical Fluctuation Imaging (SOFI)—to generate a balanced image contrast. Structures that otherwise would be masked by brighter regions in the conventional cumulant image become samples using spectral cross-cumulants.Type: ApplicationFiled: March 31, 2012Publication date: July 17, 2014Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Stefan Geissbuehler, Claudio Dellagiacoma, Matthias Geissbuehler, Theo Lasser, Marcel Leutenegger
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Publication number: 20130296715Abstract: A high-speed laser perfusion imaging instrument including a laser source, a detector, a signal-processing unit, data memory, and a screen to display results. A section of a sample surface is illuminated with laser light; reemitted light from the irradiated surface is collected by focusing optics on a 2D array of integrating photodetectors having elements that can be accessed individually or in a pre-defined selection of pixels at high speed. This 2D array measures intensity variations at each individual pixel. Average amplitude and mean frequency of the measured signal contain information about concentration and speed of moving blood cells. For real-time imaging, exposure time is used as a parameter to measure relative perfusion changes. These data are stored and processed with the signal-processing unit to deliver 2D flow maps of the illuminated sample section, and allow a simple overlay between a conventional image and processed flow maps.Type: ApplicationFiled: July 5, 2013Publication date: November 7, 2013Inventors: Theo LASSER, Marc Andre, Michael Friedrich
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Patent number: 8480579Abstract: A high-speed laser perfusion imaging instrument including a laser source, a detector, a signal-processing unit, data memory, and a screen to display results. A section of a sample surface is illuminated with laser light; reemitted light from the irradiated surface is collected by focusing optics on a 2D array of integrating photodetectors having elements that can be accessed individually or in a pre-defined selection of pixels at high speed. This 2D array measures intensity variations at each individual pixel. Average amplitude and mean frequency of the measured signal contain information about concentration and speed of moving blood cells. For real-time imaging, exposure time is used as a parameter to measure relative perfusion changes. These data are stored and processed with the signal-processing unit to deliver 2D flow maps of the illuminated sample section, and allow a simple overlay between a conventional image and processed flow maps.Type: GrantFiled: April 20, 2006Date of Patent: July 9, 2013Assignee: Ecole Polytechnique Fédérale de Lausanne (EPFL)Inventors: Alexandre Serov, Theo Lasser
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Publication number: 20130172735Abstract: The invention concerns an OCI medical device (100) comprising the following elements:—a coherent light source (120),—a 2D light sensor (120),—a screen (110) that displays OCI map and/or mixture map,—a processing unit that calculates the OCI map; all said elements being included in a single movable unit. The invention also relates to the use of said OCI medical device.Type: ApplicationFiled: March 16, 2011Publication date: July 4, 2013Applicant: AIMAGO S.A.Inventors: Marc Andre, Michael Friedrich, Andrey Naumenko, Romain Farkas, Theo Lasser
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Publication number: 20130017967Abstract: A method and device for the rapid detection of biomolecules (320) diffusing in a nanometer-confined slit (204) is claimed. In particular, the present invention relates to a novel concept of fluidic side apertures (205) that facilitates the filling of the device, the surface coating with biomolecules and that measures the affinity between fluorescently labeled biomolecules in aqueous solution with other biomolecules immobilized on surfaces.Type: ApplicationFiled: November 19, 2010Publication date: January 17, 2013Inventors: Nicolas Durand, Yannick Fournier, Theo Lasser, Iwan Märki
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Publication number: 20130016887Abstract: A method and system for the rapid detection of biomolecular interactions, the system comprising a sensing platform which comprises a primary support structure including recesses designed to be located in front of a detection unit, said recesses containing one or several arrays of biosensors, said system furthermore comprising a reader unit for optical excitation and detection.Type: ApplicationFiled: February 25, 2011Publication date: January 17, 2013Inventors: Nicolas Durand, Iwan Märki, Theo Lasser