Abstract: A system for fragmenting an eye lens nucleus has a first laser radiation source 30, configured to irradiate the eye lens nucleus with first radiation 32 suitable for Brillouin spectroscopy; an apparatus 36 for performing Brillouin spectroscopy with radiation scattered back from the eye lens nucleus in order to acquire Brillouin scattering measured data; a processing unit 50 in or from which correlations between Brillouin scattering measured data and parameters of a second radiation 52 suitable for fragmenting the eye lens nucleus 12 are stored or derived; and a second laser radiation source 44 having radiation guiding means 40, configured to irradiate the eye lens nucleus 12 with the second radiation with the parameters correlated with the Brillouin scattering measured data of the irradiated eye lens nucleus 12, in order to fragment the eye lens nucleus.

Abstract: In certain embodiments, marking a lenticule includes controlling a focus of pulsed laser radiation having ultrashort pulses. A lenticule marking is created in a cornea of an eye with the pulsed laser radiation to mark the lenticule. The lenticule is then created in the cornea with the pulsed laser radiation.

Abstract: According to certain embodiments, a method for laser cutting treatment of a human eye comprises: determining position information of a pupil center of the eye in relation to a point of minimal corneal thickness in an undeformed state of the eye; locating the point of minimal corneal thickness in a flattened state of the eye, in which the eye is deformed by contact with a patient adapter of a laser device; and aligning a pulse firing pattern for laser radiation pulses of the laser device, based on a position of the located point of minimal corneal thickness and the determined position information. In embodiments, the pulse firing pattern represents, for example, a lenticular or doughnut-shaped intracorneal tissue volume which is to be removed from the cornea of the eye.

Abstract: A method for preparing an endothelial corneal graft is provided. The method comprises: providing a donor cornea; irradiating the donor cornea from an endothelial side thereof with laser radiation to cause a photodisruption in tissue of the donor cornea at a focal point of the radiation; and moving the focal point of the radiation to form an endothelial graft in the donor cornea. By irradiating the donor cornea from the endothelial side thereof, instead of the epithelial side, to cut the endothelial graft, optical inhomogeneities which may develop after death in stromal tissue of the donor cornea leave the laser cutting process substantially unaffected.

Abstract: In certain embodiments, refractive correction includes controlling a focus of pulsed laser radiation having ultrashort pulses. A channel is created with the pulsed laser radiation to facilitate separation of the lenticule from the eye. A posterior incision is created with the pulsed laser radiation to form a posterior side of the lenticule. An anterior incision is created with the pulsed laser radiation to form an anterior side of the lenticule.

Abstract: A device for machining the cornea of a human eye with focused pulsed laser radiation includes controllable components, a control computer for controlling these components and a control program for the control computer. The control program contains instructions that are designed to generate an incision figure in the cornea permitting the insertion of an intrastromal corneal ring implant. The incision figure includes a ring incision situated totally deep within the corneal tissue and an opening incision extending at right angles to the ring plane of the ring incision from the anterior surface of the cornea or from the posterior surface of the cornea as far as at least the ring incision. The ring incision exhibits, assigned to the opening incision, a radial—relative to the ring axis—widening zone in which the opening incision impinges on the ring incision.

Abstract: A system for fragmenting an eye lens nucleus has a first laser radiation source 30, configured to irradiate the eye lens nucleus with first radiation 32 suitable for Brillouin spectroscopy; an apparatus 36 for performing Brillouin spectroscopy with radiation scattered back from the eye lens nucleus in order to acquire Brillouin scattering measured data; a processing unit 50 in or from which correlations between Brillouin scattering measured data and parameters of a second radiation 52 suitable for fragmenting the eye lens nucleus 12 are stored or derived; and a second laser radiation source 44 having radiation guiding means 40, configured to irradiate the eye lens nucleus 12 with the second radiation with the parameters correlated with the Brillouin scattering measured data of the irradiated eye lens nucleus 12, in order to fragment the eye lens nucleus.

Abstract: An apparatus for dissecting an eye for the introduction of a photosensitizer into tissue of an eye, a cannula device for introducing the photosensitizer, a system comprising the apparatus and the cannula device, and a method for dissecting an eye for the introduction of a photosensitizer are provided. The apparatus comprises a source for laser radiation, a system for guiding and focusing the laser radiation with respect to the tissue of an eye, and a computer for controlling said system.

Abstract: A marker device for producing paint marks on an eye is disclosed. The marker device comprises a handling unit and a marker unit coupled to the handling unit for rotation with respect to the handling unit about a rotational axis. The marker unit includes at least two spaced apart marking surfaces and has a rotationally symmetric distribution of weight with respect to the rotational axis. A coupling between the handling unit and the marker unit permits the marker unit to rotate, due to gravity, relative to the handling unit into an equilibrium position.

Abstract: According to certain embodiments, a method for laser cutting treatment of a human eye comprises: determining position information of a pupil center of the eye in relation to a point of minimal corneal thickness in an undeformed state of the eye; locating the point of minimal corneal thickness in a flattened state of the eye, in which the eye is deformed by contact with a patient adapter of a laser device; and aligning a pulse firing pattern for laser radiation pulses of the laser device, based on a position of the located point of minimal corneal thickness and the determined position information. In embodiments, the pulse firing pattern represents, for example, a lenticular or doughnut-shaped intracorneal tissue volume which is to be removed from the cornea of the eye.

Abstract: A method for preparing an endothelial corneal graft is provided. The method comprises: providing a donor cornea; irradiating the donor cornea from an endothelial side thereof with laser radiation to cause a photodisruption in tissue of the donor cornea at a focal point of the radiation; and moving the focal point of the radiation to form an endothelial graft in the donor cornea. By irradiating the donor cornea from the endothelial side thereof, instead of the epithelial side, to cut the endothelial graft, optical inhomogeneities which may develop after death in stromal tissue of the donor cornea leave the laser cutting process substantially unaffected.

Abstract: An apparatus for dissecting an eye for the introduction of a photosensitizer into tissue of an eye, a cannula device for introducing the photosensitizer, a system comprising the apparatus and the cannula device, and a method for dissecting an eye for the introduction of a photosensitizer are provided. The apparatus comprises a source for laser radiation, a system for guiding and focusing the laser radiation with respect to the tissue of an eye, and a computer for controlling said system.

Abstract: A system and method for reshaping a cornea of a patient's eye to treat presbyopia are disclosed as well as a method of generating a computer program for use in such system. Ray tracing is used to determine an ablation pattern that defines an amount of corneal tissue to be ablated, wherein the ablation pattern achieves a pre-defined amount of at least one of sphere, spherical aberration, coma, and astigmatism in the eye.

Abstract: In certain embodiments, marking a lenticule includes controlling a focus of pulsed laser radiation having ultrashort pulses. A lenticule marking is created in a cornea of an eye with the pulsed laser radiation to mark the lenticule. The lenticule is then created in the cornea with the pulsed laser radiation.

Abstract: An apparatus for generating an alteration of biomechanical properties of ocular tissue, into which a photosensitizer (14) has been introduced, contains means (18, 20) for radiating into the tissue electromagnetic radiation (12?) which reacts with the photosensitizer for the purpose of generating a cross-linking. The setting means permit an inhomogeneous distribution of the irradiance in the tissue and a setting of the depth of action (16?).

Abstract: A device for machining the cornea of a human eye with focused pulsed laser radiation includes controllable components, a control computer for controlling these components and a control program for the control computer. The control program contains instructions that are designed to generate an incision figure in the cornea permitting the insertion of an intrastromal corneal ring implant. The incision figure includes a ring incision situated totally deep within the corneal tissue and an opening incision extending at right angles to the ring plane of the ring incision from the anterior surface of the cornea or from the posterior surface of the cornea as far as at least the ring incision. The ring incision exhibits, assigned to the opening incision (44), a radial—relative to the ring axis—widening zone in which the opening incision impinges on the ring incision.

Abstract: A device for dissecting an eye for the introduction of photosensitizer into the cornea where laser radiation is focused in the interior of the cornea to create cavitation bubbles, whereby channels are created in the cornea through which the photosensitizer can be introduced into the cornea. Furthermore, a method for refractive surgery includes utilizing a sensitizer for hardening corneal tissue by cross-linking.

Abstract: In certain embodiments, refractive correction includes controlling a focus of pulsed laser radiation having ultrashort pulses. A channel is created with the pulsed laser radiation to facilitate separation of the lenticule from the eye. A posterior incision is created with the pulsed laser radiation to form a posterior side of the lenticule. An anterior incision is created with the pulsed laser radiation to form an anterior side of the lenticule.

Abstract: Systems and methods for treating presbyopia are provided. In one embodiment, a system for photorefractive treatment of presbyopia includes a laser source configured for ablating corneal tissue and a control system in communication with the laser source and configured to control the laser source to ablate conical tissue of a patient to achieve a desired corneal shape. In some instances, the control system controls the laser source by calculating a global optimum regarding curvature and asphericity of the cornea. In some instances, control system controls the laser source by calculating a central steep island and calculating a curvature and asphericity for the rest of the cornea. In some embodiments, a laser source is controlled to ablate the cornea of the patient in accordance with a calculated shape profile to achieve a desired corneal shape.

Abstract: An apparatus for generating an alteration of biomechanical properties of ocular tissue, into which a photosensitiser (14) has been introduced, contains means (18, 20) for radiating into the tissue electromagnetic radiation (12?) which reacts with the photosensitiser for the purpose of generating a cross-linking. The setting means permit an inhomogeneous distribution of the irradiance in the tissue and a setting of the depth of action (16?).